Sensitization symptoms are associated with psychological and cognitive variables in COVID-19 survivors exhibiting post-COVID pain

Article Anesthesiology

Characteristics and influence on quality of life of new-onset pain in critical COVID-19 survivors

Antonio Ojeda et al.

Summary: This study examined the occurrence of new-onset pain in COVID-19 survivors after hospital discharge and its impact on Health-Related Quality of Life (HRQoL), revealing a negative correlation between pain and HRQoL.

EUROPEAN JOURNAL OF PAIN (2022)

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Article Anesthesiology

Insight into pain syndromes in acute phase of mild-to-moderate COVID-19: Frequency, clinical characteristics, and associated factors

Emel Oguz-Akarsu et al.

Summary: This study identified the main pain syndromes associated with the acute phase of mild-to-moderate COVID-19 and their characteristics. There are significant relationships between pain syndromes in COVID-19, which may be due to a sequence of common etiologic factors.

EUROPEAN JOURNAL OF PAIN (2022)

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Review Anesthesiology

Time course prevalence of post-COVID pain symptoms of musculoskeletal origin in patients who had survived severe acute respiratory syndrome coronavirus 2 infection: a systematic review and meta-analysis

Cesar Fernandez-de-las-Penas et al.

Summary: This review or meta-analysis aims to analyze the prevalence of musculoskeletal pain symptoms after COVID-19 infection among hospitalized or nonhospitalized patients. The analysis showed that nearly 10% of individuals infected with SARS-CoV-2 will experience musculoskeletal post-COVID pain symptoms during the first year after infection.

PAIN (2022)

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Article Anesthesiology

Prevalence and risk factors of musculoskeletal pain symptoms as long-term post-COVID sequelae in hospitalized COVID-19 survivors: a multicenter study

Cesar Fernandez-de-las-Penas et al.

Summary: This study investigated the prevalence and risk factors of long-term musculoskeletal post-COVID pain in COVID-19 survivors. The study found that 45.1% of survivors experienced musculoskeletal post-COVID pain 8 months after hospital discharge, and risk factors included female sex, history of musculoskeletal pain, presence of myalgia and headache as COVID-19 symptoms, and days at hospital.

PAIN (2022)

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Article Anesthesiology

Characteristics and Risk Factors of Persistent Neuropathic Pain in Recovered COVID-19 Patients

Rehab Magdy et al.

Summary: The study revealed that factors such as depression, azithromycin use, severity of COVID-19, and serum ferritin levels were significantly associated with persistent post-COVID-19 pain. Serum NFL levels may serve as a potential biomarker for persistent neuropathic pain following COVID-19.

PAIN MEDICINE (2022)

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Editorial Material Anesthesiology

Manifestations of Pain During the COVID-19 Pandemic Portrayed on Social Media: A Cross-Sectional Study

Ryan S. D'Souza et al.

PAIN MEDICINE (2022)

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Editorial Material Orthopedics

Clinimetrics: The Central Sensitisation Inventory: a useful screening tool for clinicians, but not the gold standard

Jo Nijs et al.

JOURNAL OF PHYSIOTHERAPY (2022)

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Review Anesthesiology

Chronic primary pain in the COVID-19 pandemic: how uncertainty and stress impact on functioning and suffering

Ann Meulders et al.

PAIN (2022)

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Article Anesthesiology

The Relationship Between Pain and Psychological Distress During the COVID-19 Pandemic: Is Social Technology Use Protective?

Yulin Yang et al.

Summary: This study examines the relationship between pain and psychological distress among adults ages 54 and older during the COVID-19 pandemic. The findings suggest that older adults with pain are at higher risk of depression, anxiety, and loneliness during the pandemic. Additionally, the use of social technology may have different effects on individuals with pain compared to those without pain.

PAIN MEDICINE (2022)

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Review Medicine, General & Internal

Deciphering the COVID-19 cytokine storm: Systematic review and meta-analysis

Rubina Mulchandani et al.

Summary: Studies have shown significantly elevated levels of pro-inflammatory cytokines and reduced T lymphocytes in severe COVID-19 cases. However, there is heterogeneity across studies due to small sample sizes, nonuniform outcome assessment, and varied definitions of disease severity, indicating a need for well-designed and adequately powered prospective studies for more definitive answers.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Rheumatology

Fibromyalgia: a new facet of the post-COVID-19 syndrome spectrum? Results from a web-based survey

Francesco Ursini et al.

Summary: The study found that the prevalence of FM is relatively high in patients who recovered from COVID-19, with male gender and obesity being among the strongest predictors for developing post-COVID-19 FM.

RMD OPEN (2021)

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Article Medicine, General & Internal

Is Central Sensitisation the Missing Link of Persisting Symptoms after COVID-19 Infection?

Lisa Goudman et al.

Summary: The study found that over 70% of patients post COVID-19 infection exhibit symptoms of central sensitisation, suggesting the need for patient education and multimodal rehabilitation to address nociplastic pain.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Anesthesiology

Chronic nociplastic pain affecting the musculoskeletal system: clinical criteria and grading system

Eva Kosek et al.

PAIN (2021)

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Article Multidisciplinary Sciences

More than 50 long-term effects of COVID-19: a systematic review and meta-analysis

Sandra Lopez-Leon et al.

Summary: This study aimed to identify studies assessing the long-term effects of COVID-19, estimating that 80% of infected patients will develop one or more long-term symptoms, with the most common being fatigue, headache, attention disorder, hair loss, and dyspnea.

SCIENTIFIC REPORTS (2021)

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Review Clinical Neurology

COVID-Pain: Acute and Late-Onset Painful Clinical Manifestations in COVID-19-Molecular Mechanisms and Research Perspectives

Marco Cascella et al.

Summary: Apart from respiratory symptoms, COVID-19 can also present with extra-pulmonary manifestations, including various types of pain. Using the term "COVID-pain" may be more appropriate to encompass all these clinical manifestations in a separate chapter of the disease. This review aims to dissect the mechanisms of acute and chronic painful manifestations from a molecular perspective while summarizing fundamental concepts, controversies, current research gaps, and potential developments in this field.

JOURNAL OF PAIN RESEARCH (2021)

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Review Medicine, General & Internal

Nociplastic Pain Criteria or Recognition of Central Sensitization? Pain Phenotyping in the Past, Present and Future

Jo Nijs et al.

Summary: IASP has recently released new clinical criteria for nociplastic pain affecting the musculoskeletal system, aiming to help clinicians identify and classify patients with chronic pain more accurately. These new criteria are more comprehensive and robust, representing important steps towards precision pain medicine, although further studies are needed to validate their clinimetric and psychometric properties.

JOURNAL OF CLINICAL MEDICINE (2021)

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Review Neurosciences

Do central sensitization questionnaires reflect measures of nociceptive sensitization or psychological constructs? Protocol for a systematic review

Greig R. Adams et al.

Summary: Central sensitization refers to increased nociceptive responsiveness due to sensitization of neurons in the central nervous system. Diagnosis has expanded to include sensory and emotional responses, and central sensitivity syndrome is associated with hypervigilant sensory and emotional responses. Self-report questionnaires and assessments of behavior and emotional disposition are used in diagnosis.

PAIN REPORTS (2021)

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Review Neurosciences

Do central sensitization questionnaires reflect measures of nociceptive sensitization or psychological constructs? Protocol for a systematic review

Greig R. Adams et al.

Summary: This systematic review protocol aims to examine the correlation between central sensitisation questionnaires and sensory or psychological measures to clarify its clinical application. By synthesizing the associations, the review seeks to determine whether these questionnaires more effectively capture a broader understanding of sensitivity.

PAIN REPORTS (2021)

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Article Primary Health Care

Central Sensitization Phenotypes in Post Acute Sequelae of SARS-CoV-2 Infection (PASC): Defining the Post COVID Syndrome

Dennis M. Bierle et al.

Summary: The aim of the study was to develop criteria for description of Post COVID syndrome based on analysis of patients at Mayo Clinic Rochester. Through thorough review using DELPHI method, 42 cases with persistent central sensitization symptoms after acute COVID-19 were identified as Post COVID syndrome (PoCoS). The study found that pain, fatigue, dyspnea, and orthostatic intolerance were the most common symptoms among these PoCoS patients.

JOURNAL OF PRIMARY CARE AND COMMUNITY HEALTH (2021)

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Article Anesthesiology

Cross-sectional study of psychosocial and pain-related variables among patients with chronic pain during a time of social distancing imposed by the coronavirus disease 2019 pandemic

Valerie Hruschak et al.

Summary: The study found that during the COVID-19 pandemic, individuals with chronic pain experienced a significant increase in pain severity and interference, particularly among females, nonwhite individuals, those with lower education levels, disabilities, fibromyalgia, and higher pain catastrophizing. Therefore, individual differences among patients with chronic pain should be considered in planning interventions to improve pain care.

PAIN (2021)

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Review Anesthesiology

Methods to discriminate between mechanism-based categories of pain experienced in the musculoskeletal system: a systematic review

Muath A. Shraim et al.

Summary: Mechanism-based classification of pain is advocated to tailor interventions for persistent musculoskeletal pain. However, discrimination between nociceptive, neuropathic, and nociplastic pain categories remains challenging. Few validated methods exist, with recommendations for a combination of features and methods for discrimination.

PAIN (2021)

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Review Rheumatology

Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine

Jo Nijs et al.

Summary: Chronic pain is a major cause of disability and high healthcare costs globally. Central sensitisation, amplification of neural signalling in the CNS leading to pain hypersensitivity, has been investigated as a reason for discrepancy between tissue damage extent and pain severity. Central sensitisation varies among patients with different pain conditions, predicting poor treatment outcomes and suggesting the importance of individual assessment and treatment strategies.

LANCET RHEUMATOLOGY (2021)

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Article Psychology, Clinical

Chronic pain in the time of COVID-19: Stress aftermath and central sensitization

Elena R. Serrano-Ibanez et al.

Summary: The COVID-19 crisis has been found to be associated with changes in daily routines, pain intensity, emotional distress, and sensitization scores. There were correlations between emotional distress, sensitization, and pain intensity. Significant predictors of emotional distress included age, difficulty in receiving medical care, changes in daily routines, and diminished social support. Emotional distress did not mediate the association between sensitization and pain intensity.

BRITISH JOURNAL OF HEALTH PSYCHOLOGY (2021)

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Article Multidisciplinary Sciences