Journal
NUTRIENTS
Volume 14, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/nu14132698
Keywords
ischemic stroke; post-stroke depression; depression; geriatric nutritional risk index; malnutrition; China
Categories
Funding
- National Science Foundation of China [82071300]
- Health Expert Training Program of Suzhou-Gusu District [GSWS2020002]
- Medical Team Introduction Program of Soochow [SZYJTD201802]
- National Natural Science Foundation of China [82001125]
- Natural Science Foundation of Jiangsu Province [BK20180201]
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The study found that a low GNRI was not associated with an increased risk of depression after ischemic stroke. While some patients had malnutrition, the association between nutritional status and PSD remains unclear.
Background: Malnutrition is associated with poor outcomes after stroke. However, the association between malnutrition and post-stroke depression (PSD) remains unelucidated. We aimed to explore the association between geriatric nutritional risk index (GNRI) and depression after ischemic stroke. Methods: In total, 344 patients with ischemic stroke were included in this analysis. The GNRI was calculated from serum albumin level, weight, and height at admission. Malnutrition was defined using the GNRI cutoff points. A lower GNRI score indicates an elevated nutritional risk. The outcome was depression, measured 14 days after ischemic stroke. Logistic regression models were used to estimate the association between the GNRI and risk of PSD. Results: A total of 22.9% developed PSD 14 days after stroke. The mean GNRI was 99.3 +/- 6.0, and 53.8% of the patients had malnutrition. After adjusting for covariates, baseline malnutrition was not associated with risk of PSD (OR, 0.670; 95%CI, 0.370-1.213; p = 0.186). The restricted cubic splines revealed a U-shaped association between the GNRI and PSD. Compared to moderate GNRI, higher GNRI (OR, 2.368; 95%CI, 0.983-5.701; p = 0.085) or lower GNRI (OR, 2.226; 95%CI, 0.890-5.563; p = 0.087) did not significantly increase the risk of PSD. Conclusion: A low GNRI was not associated with an increased risk of depression after ischemic stroke.
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