Journal
NUTRIENTS
Volume 14, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/nu14153245
Keywords
ketogenic diet; Very Low-Calories Ketogenic Diet; DNA methylation; histone modifications; miRNAs
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Funding
- Ministero dell'Istruzione, Universita e Ricerca [20173CRP3H_002]
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Ketogenic diets are effective in the treatment of obesity, metabolic diseases, and other conditions. However, limited data is available on the epigenetic changes associated with these diets.
Ketogenic diets (KD) are dietary strategies low in carbohydrates, normal in protein, and high, normal, or reduced in fat with or without (Very Low-Calories Ketogenic Diet, VLCKD) a reduced caloric intake. KDs have been shown to be useful in the treatment of obesity, metabolic diseases and related disorders, neurological diseases, and various pathological conditions such as cancer, nonalcoholic liver disease, and chronic pain. Several studies have investigated the intracellular metabolic pathways that contribute to the beneficial effects of these diets. Although epigenetic changes are among the most important determinants of an organism's ability to adapt to environmental changes, data on the epigenetic changes associated with these dietary pathways are still limited. This review provides an overview of the major epigenetic changes associated with KDs.
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