Vitamin D Status and Mortality from SARS CoV-2: A Prospective Study of Unvaccinated Caucasian Adults

Article Medicine, General & Internal

Vitamin D deficiency is associated with higher risks for SARS-CoV-2 infection and COVID-19 severity: a retrospective case-control study

Ariel Israel et al.

Summary: This study found a significant association between vitamin D deficiency and the risks of SARS-CoV-2 infection and severe disease in those infected.

INTERNAL AND EMERGENCY MEDICINE (2022)

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Article Environmental Sciences

The Interaction of Vitamin D and Corticosteroids: A Mortality Analysis of 26,508 Veterans Who Tested Positive for SARS-CoV-2

Jimmy T. Efird et al.

Summary: This study found that the use of vitamin D can reduce mortality risk in hospitalized COVID-19 patients, and when combined with systemic corticosteroids, it is associated with lower death rates in hospitalized patients but higher death rates in non-hospitalized patients.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2022)

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Review Pharmacology & Pharmacy

Title: Understanding a Low Vitamin D State in the Context of COVID-19

James Bernard Walsh et al.

Summary: This review examines the association between vitamin D, SARS-CoV-2 infection, and COVID-19 severity. The authors conclude that there is a causal relationship between low vitamin D status and increased risk of infection and severe COVID-19. They suggest that vitamin D supplementation may be beneficial for improving immunity against SARS-CoV-2, especially in vulnerable populations. The study highlights the prevalence of low vitamin D status among Irish adults.

FRONTIERS IN PHARMACOLOGY (2022)

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Article Medicine, General & Internal

Perspective: Vitamin D deficiency and COVID-19 severity - plausibly linked by latitude, ethnicity, impacts on cytokines, ACE2 and thrombosis

J. M. Rhodes et al.

Summary: There is substantial evidence supporting a link between vitamin D deficiency and COVID-19 severity, although the evidence is indirect. Community-based placebo-controlled trials of vitamin D supplementation may be challenging, but further evidence may come from large cohort studies with prescribing data or serum 25(OH) vitamin D level assays. In the meantime, vitamin D supplementation is strongly recommended for individuals at risk of deficiency.

JOURNAL OF INTERNAL MEDICINE (2021)

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Article Pathology

Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality

Dieter De Smet et al.

Summary: Vitamin D deficiency is associated with COVID-19 disease stage and mortality, particularly in male patients, independent of age, ethnicity, and comorbidities. Male patients with COVID-19 showed progressively lower 25(OH)D levels with advancing radiologic stage, and deficiency on admission was associated with increased mortality risk.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2021)

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Article Medicine, General & Internal

Vitamin D Status Is Associated With In-Hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients

Angeliki M. Angelidi et al.

Summary: A study found an inverse association between serum 25-hydroxyvitamin D levels and in-hospital mortality and the need for invasive mechanical ventilation in patients admitted with laboratory-confirmed COVID-19. Further observational studies are needed to confirm these findings, and randomized clinical trials should be conducted to assess the role of vitamin D administration in improving the morbidity and mortality of COVID-19.

MAYO CLINIC PROCEEDINGS (2021)

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Letter Endocrinology & Metabolism

Letter to the Editor: Vitamin D deficiency in COVID-19: Mixing up cause and consequence

Joost Smolders et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2021)

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Review Nutrition & Dietetics

Association of Vitamin D Status with SARS-CoV-2 Infection or COVID-19 Severity: A Systematic Review and Meta-analysis

Asma Kazemi et al.

Summary: This systematic review suggests a significant association between 25(OH)D and SARS-CoV-2 infection, COVID-19 severity, and mortality, although there are inconsistencies in some findings. Evidence regarding ICU admission, inflammation, hospitalization, and pulmonary complications is currently inconsistent and insufficient.

ADVANCES IN NUTRITION (2021)

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Article Endocrinology & Metabolism

Effects of Monthly Intramuscular High-Dose Vitamin D2 on Serum 25-Hydroxyvitamin D and Immune Parameters in Very Elderly Chinese Patients with Vitamin D Deficiency

Pingda Bian et al.

Summary: The study demonstrates that high-dose intramuscular injection of vitamin D2 is effective and safe in correcting vitamin D deficiency and enhancing immune function in very elderly Chinese patients.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2021)

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Review Nutrition & Dietetics

COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis

Lorenz Borsche et al.

Summary: Research indicates a negative correlation between D3 levels and COVID-19 mortality rates, suggesting that low D3 levels are a predictor of infection severity. It is recommended to raise serum 25(OH)D levels above 50 ng/mL to prevent or mitigate new outbreaks caused by escape mutations or decreasing antibody activity, despite ongoing vaccinations.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

Lack of association of baseline 25-hydroxyvitamin D levels with disease severity and mortality in Indian patients hospitalized for COVID-19

Ganesh Jevalikar et al.

Summary: The study found that there was no significant difference in clinical outcomes or mortality between COVID-19 hospitalized patients with Vitamin D deficiency (VDD) and those without VDD, and serum 25-OHD levels did not correlate with inflammatory markers. Treatment with cholecalciferol for VDD did not impact outcomes.

SCIENTIFIC REPORTS (2021)

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Article Nutrition & Dietetics

Low Serum 25-hydroxyvitamin D (Vitamin D) Level Is Associated With Susceptibility to COVID-19, Severity, and Mortality: A Systematic Review and Meta-Analysis

Mohammad Rizki Akbar et al.

Summary: The study concluded that low serum 25-OHD levels were associated with higher susceptibility to COVID-19 infection, severe presentation of the disease, and increased mortality rates.

FRONTIERS IN NUTRITION (2021)

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Article Infectious Diseases

Vitamin D and COVID-19 severity and related mortality: a prospective study in Italy

Irene Campi et al.

Summary: In COVID-19 patients, low 25OHD levels were inversely correlated with high IL-6 levels and were independent predictors of COVID-19 severity and mortality.

BMC INFECTIOUS DISEASES (2021)

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Review Biochemistry & Molecular Biology

Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies

Fausto Petrelli et al.

Summary: Vitamin D plays a protective role by modulating the immune system and systemic inflammatory response, reducing the risk and severity of COVID-19 infection. Patients with deficient vitamin D levels are more likely to be infected with COVID-19, and are more likely to experience severe symptoms and death.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

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Article Medicine, General & Internal

Vitamin D status and outcomes for hospitalised older patients with COVID-19

Vadir Baktash et al.

Summary: The study aimed to assess the importance of vitamin D deficiency in older patients with COVID-19, finding a potential association between vitamin D deficiency and worse outcomes in COVID-19 cases among older adults, without an increased mortality rate.

POSTGRADUATE MEDICAL JOURNAL (2021)

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Article Medical Laboratory Technology

Serum 25(OH)D Deficiency and High D-Dimer Levels are Associated with COVID-19 Pneumonia

Aysel Sunnetcioglu et al.

Summary: Risk factors for COVID-19 pneumonia include elevated levels of D-dimer, deficiency in 25(OH)D, and older age. Common comorbidities in patients with pneumonia include hypertension, diabetes, and cardiovascular disease.

CLINICAL LABORATORY (2021)

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Article Biochemistry & Molecular Biology