Journal
NUTRIENTS
Volume 14, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/nu14153169
Keywords
Cyclocarya paliurus; metabolic diseases; type 2 diabetes; glucose metabolism; insulin secretion
Categories
Funding
- National Natural Science Foundation of China [31770948, 31570875, 81803547]
- Natural Science Foundation of Fujian Province, China [2021J01204]
- Fujian Provincial Regional Development Project [2021N3005]
- Special Sci-tech Team Commissioner of Fujian province [T202005007, T202005013]
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This article reviews the regulatory mechanism of glucose metabolism by C. paliurus and explores its potential application in the prevention and treatment of metabolic diseases such as diabetes, hyperlipidemia, and obesity.
Globally, the incidence of diabetes is increasing annually, and China has the largest number of patients with diabetes. Patients with type 2 diabetes need lifelong medication, with severe cases requiring surgery. Diabetes treatment may cause complications, side-effects, and postoperative sequelae that could lead to adverse health problems and significant social and economic burdens; thus, more efficient hypoglycemic drugs have become a research hotspot. Glucose metabolism disorders can promote diabetes, a systemic metabolic disease that impairs the function of other organs, including the heart, liver, and kidneys. Cyclocarya paliurus leaves have gathered increasing interest among researchers because of their effectiveness in ameliorating glucose metabolism disorders. At present, various compounds have been isolated from C. paliurus, and the main active components include polysaccharides, triterpenes, flavonoids, and phenolic acids. C. paliurus mainly ameliorates glucose metabolism disorders by reducing glucose uptake, regulating blood lipid levels, regulating the insulin signaling pathway, reducing beta-cell apoptosis, increasing insulin synthesis and secretion, regulating abundances of intestinal microorganisms, and exhibiting alpha-glucosidase inhibitor activity. In this paper, the mechanism of glucose metabolism regulation by C. paliurus was reviewed to provide a reference to prevent and treat diabetes, hyperlipidaemia, obesity, and other metabolic diseases.
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