Journal
NUTRIENTS
Volume 14, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/nu14142821
Keywords
age-related macular degeneration; vitamins B; folate; epidemiology; nutrition; cohort; risk; population
Categories
Funding
- Thea Pharma
- Fondation Voir et Entendre
- Agence Nationale de la Recherche [ANR 2010-PRSP-011 VISA]
- French Ministry of Health [PHRC 12_157]
- CFSR Recherche (Club Francais des Specialistes de la Retine)
- Fondation Visio
- CNSA (Caisse Nationale pour la Solidarite et l'Autonomie)
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B vitamins may protect against age-related macular degeneration (AMD), as suggested by a cohort study on older adults in Bordeaux, France. The study found a significant association between normal serum folate levels and a high dietary intake of B5 and B6 with a lower risk for developing advanced AMD. Adopting a healthy diet rich in B vitamins may help reduce vision loss due to AMD.
B vitamins may protect against age-related macular degeneration (AMD). We evaluated the associations of dietary intake and serum vitamins with the incidence of advanced AMD in the Alienor study. The Alienor study is a prospective population-based cohort of 963 residents of Bordeaux, France, who were 73 years or older at baseline (2006-2008). Examinations were performed every two years over an eight-year period. The incidence of AMD is based on retinal fundus photographs and spectral-domain optical coherence tomography examinations. Among the 861 included participants, 93 developed incident AMD during a median follow-up time of 9.8 years. Participants with normal serum folate (>= 10 nmol/L) significantly had a 51% reduced risk for AMD in the fully adjusted Cox model (HR, 0.49 [95% CI, 0.25-0.95], p = 0.036). Participants with a higher dietary intake of B5 and B6 vitamins had a lower risk for developing AMD of up to 28% (HR, 0.72 for 1-SD increase [0.53-0.99], p = 0.049; HR, 0.90 [0.81-0.99], p = 0.049, respectively). This cohort study of older adults suggests a strong association between a normal serum folate status, a high dietary intake of B5 and B6 and a lower risk for developing advanced AMD. Adopting a healthy diet rich in B vitamins may help to reduce vision loss due to AMD.
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