Journal
NUTRIENTS
Volume 14, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/nu14122386
Keywords
glucose; insulin; oral nutritional supplement; prediabetes; isomaltulose; dietary fiber
Categories
Funding
- Morinaga Milk Industry Co., Ltd., Tokyo, Japan
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This study suggests that a low-carbohydrate oral dietary supplement can effectively reduce blood glucose levels in individuals with prediabetes. It contains slowly digestible carbohydrate, isomaltulose, and soluble dietary fiber, making it a suitable energy supplement for individuals with postprandial hyperglycemia.
A high-energy-type oral dietary supplement (ONS), with a low proportion of available carbohydrate (LC-ONS), which contains a slowly digestible carbohydrate, isomaltulose, and is fortified with soluble dietary fiber, was newly developed for individuals with diabetes or prediabetes. This study aimed to evaluate the impact of LC-ONS on blood glucose levels after ingestion in individuals with prediabetes. A single-blind, randomized crossover clinical trial was performed on 20 individuals with prediabetes. After overnight fasting, all subjects ingested one serving (200 kcal/125 mL) of either LC-ONS (40% energy proportion of available carbohydrates) or standard ONS (ST-ONS, 54% energy proportion of available carbohydrates) on two separate days. The incremental area under the curve of blood glucose levels for 120 min was significantly lower after LC-ONS ingestion compared to ST-ONS (2207 +/- 391 mg/dL center dot min (least mean square value +/- standard error) and 3735 +/- 391 mg/dL center dot min, respectively; p < 0.001). The LC-ONS showed significantly lower blood glucose levels than the ST-ONS at all time points, except at baseline. Similarly, the incremental area under the curve of plasma insulin was significantly lower after LC-ONS ingestion. These results suggest that LC-ONS is useful as an ONS for energy supply in individuals with postprandial hyperglycemia.
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