Journal
NUTRIENTS
Volume 14, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/nu14122388
Keywords
Cushing's syndrome; glucocorticoid; cortisol; diabetes mellitus; obesity
Categories
Ask authors/readers for more resources
A very low-calorie ketogenic diet (VLCKD) can effectively improve lipid parameters, blood pressure, glycaemic indices and insulin sensitivity in patients with obesity and type 2 diabetes mellitus. This article discusses the relationship between hypercortisolism and nutrition, and explores the potential use of a VLCKD for the treatment of comorbidities associated with Cushing's syndrome.
A very low-calorie ketogenic diet (VLCKD) is characterized by low daily caloric intake (less than 800 kcal/day), low carbohydrate intake (<50 g/day) and normoproteic (1-1.5 g of protein/kg of ideal body weight) contents. It induces a significant weight loss and an improvement in lipid parameters, blood pressure, glycaemic indices and insulin sensitivity in patients with obesity and type 2 diabetes mellitus. Cushing's syndrome (CS) is characterized by an endogenous or exogenous excess of glucocorticoids and shows many comorbidities including cardiovascular disease, obesity, type 2 diabetes mellitus and lipid disorders. The aim of this speculative review is to provide an overview on nutrition in hypercortisolism and analyse the potential use of a VLCKD for the treatment of CS comorbidities, analysing the molecular mechanisms of ketogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available