Journal
NUTRIENTS
Volume 14, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/nu14122401
Keywords
Panax; ginseng; blood lipid; inflammation; cardiometabolic indicators; prediabetes; diabetes mellitus
Categories
Ask authors/readers for more resources
This study conducted a systematic literature search and meta-analyses to investigate the effects of ginseng supplementation on cardiometabolic biomarkers in individuals with prediabetes and type 2 diabetes. The results showed that ginseng supplementation significantly improved blood glucose, cholesterol, and inflammatory markers, but increased heart rate and TNF-alpha levels.
Results from different clinical trials on the effects of ginseng on prediabetes and type 2 diabetes (T2DM) are still inconsistent. To fill this knowledge gap, we investigated the overall effects of ginseng supplementation on improving cardiometabolic biomarkers among these patients. A systematic literature search was conducted on PubMed/MEDLINE, Scopus, Web of Science, and Cochrane library. A random-effect model was applied to estimate the weighted mean difference and 95% CI for each outcome. Overall, 20 eligible RCTs were included. Meta-analyses revealed that ginseng supplementation significantly reduced serum concentration of FPG, TC, IL-6, and HOMA-IR values. It also increased HR and TNF-alpha levels. Ginseng supplementation changed HOMA-IR and HDL-C significantly based on dose and changed HOMA-IR and LDL-C significantly based on study duration in a non-linear fashion. Furthermore, meta-regression analyses indicated a linear relationship between ginseng dose and absolute changes in HDL-C. Moreover, subgroup analyses showed that ginseng supplementation changed TC and LDL-C when the supplementation dose was >= 2 g/day. Our findings suggest that ginseng supplementation may be an effective strategy for improving cardiometabolic profiles in individuals with prediabetes and T2DM.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available