4.7 Article

Metabolic Score for Insulin Resistance Is Inversely Related to Incident Advanced Liver Fibrosis in Patients with Non-Alcoholic Fatty Liver Disease

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

Dose-Response Associations of Metabolic Score for Insulin Resistance Index with Nonalcoholic Fatty Liver Disease among a Nonobese Chinese Population: Retrospective Evidence from a Population-Based Cohort Study

Xintian Cai et al.

Summary: This study investigated the association between the metabolic score for insulin resistance (METS-IR) index and nonalcoholic fatty liver disease (NAFLD) in the nonobese population and its predictive value. The results showed that elevated METS-IR was independently associated with an increased risk of NAFLD development, and there was a dose-response relationship. METS-IR may be a reliable indicator for screening individuals at risk for early NAFLD in nonobese populations.

DISEASE MARKERS (2022)

Article Endocrinology & Metabolism

Changes in Insulin Resistance Index and the Risk of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease without Diabetes: Kangbuk Samsung Health Study

Dae-Jeong Koo et al.

Summary: This study found a positive association between changes in HOMA-IR values and changes in fibrosis status in NAFLD patients without diabetes, indicating the significant role of insulin resistance in liver fibrosis progression.

ENDOCRINOLOGY AND METABOLISM (2021)

Review Medicine, General & Internal

Liver Fibrosis in Non-alcoholic Fatty Liver Disease: From Liver Biopsy to Non-invasive Biomarkers in Diagnosis and Treatment

Leen J. M. Heyens et al.

Summary: NAFLD progression from isolated steatosis to fibrosis involves liver inflammation leading to fibrosis, cirrhosis, and even hepatocellular carcinoma. Fibrosis is a crucial predictor of prognosis in NAFLD patients, but accurate detection and treatment methods are lacking.

FRONTIERS IN MEDICINE (2021)

Article Endocrinology & Metabolism

Performance of non-invasive fibrosis scores in non-alcoholic fatty liver disease with and without morbid obesity

Andreas Drolz et al.

Summary: The study assessed the applicability and reliability of non-invasive fibrosis scores in NAFLD patients, finding that FIB-4 score accurately predicts advanced fibrosis in all BMI stages, while NFS tends to overestimate fibrosis in morbidly obese NAFLD patients. Adjustments may be needed for accurate assessment.

INTERNATIONAL JOURNAL OF OBESITY (2021)

Article Multidisciplinary Sciences

Baseline homeostasis model assessment of insulin resistance associated with fibrosis progression in patients with nonalcoholic fatty liver disease without diabetes: A cohort study

Dae-Jeong Koo et al.

Summary: The study found that baseline insulin resistance, as assessed by HOMA-IR values, was positively associated with future fibrosis progression in patients with NAFLD without diabetes. This association was maintained throughout the entire follow-up period, with insulin resistance being a more superior predictor compared to BMI in predicting fibrosis progression.

PLOS ONE (2021)

Review Gastroenterology & Hepatology

Current and Emerging Approaches for Hepatic Fibrosis Treatment

Jingguo Li et al.

Summary: Liver fibrosis is a key factor in the development of liver cirrhosis and hepatocellular carcinoma, and understanding its mechanisms has led to new opportunities for treatment. Different potential therapies such as drug treatment, cell therapy, and liver transplantation offer a variety of treatment options for liver fibrosis.

GASTROENTEROLOGY RESEARCH AND PRACTICE (2021)

Review Cell Biology

Liver Fibrosis: Therapeutic Targets and Advances in Drug Therapy

Zui Tan et al.

Summary: Liver fibrosis is a result of abnormal wound repair response caused by chronic liver injuries, potentially leading to severe diseases. The detailed mechanism of reversing liver fibrosis is still unclear, posing a challenge in the development of anti-fibrosis drugs.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Biochemistry & Molecular Biology

The Role of Insulin Resistance and Diabetes in Nonalcoholic Fatty Liver Disease

Hideki Fujii et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Endocrinology & Metabolism

METS-IR, a novel score to evaluate insulin sensitivity, is predictive of visceral adiposity and incident type 2 diabetes

Omar Yaxmehen Bello-Chavolla et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2018)

Review Biotechnology & Applied Microbiology

Lipometabolism and Glycometabolism in Liver Diseases

Hao-ran Ding et al.

BIOMED RESEARCH INTERNATIONAL (2018)

Review Gastroenterology & Hepatology

Abnormalities of Lipoprotein Levels in Liver Cirrhosis: Clinical Relevance

Graziella Privitera et al.

DIGESTIVE DISEASES AND SCIENCES (2018)

Article Public, Environmental & Occupational Health

Cohort Profile: The Korean Genome and Epidemiology Study (KoGES) Consortium

Yeonjung Kim et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2017)

Article Medicine, General & Internal

Is HOMA-IR a potential screening test for non-alcoholic fatty liver disease in adults with type 2 diabetes?

Gala Gutierrez-Buey et al.

EUROPEAN JOURNAL OF INTERNAL MEDICINE (2017)

Article Biochemistry & Molecular Biology

The triglyceride and glucose index (TyG) is an effective biomarker to identify nonalcoholic fatty liver disease

Shujun Zhang et al.

LIPIDS IN HEALTH AND DISEASE (2017)

Article Endocrinology & Metabolism

Non-alcoholic fatty liver disease and dyslipidemia: An update

Niki Katsiki et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2016)

Article Gastroenterology & Hepatology

Low-fasting triglyceride levels are associated with non-invasive markers of advanced liver fibrosis among adults in the United States

Z. G. Jiang et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2015)

Review Gastroenterology & Hepatology

Prevalence and Mechanisms of Malnutrition in Patients With Advanced Liver Disease, and Nutrition Management Strategies

Kally Cheung et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2012)

Article Endocrinology & Metabolism

Defining Insulin Resistance From Hyperinsulinemic-Euglycemic Clamps

Charmaine S. Tam et al.

DIABETES CARE (2012)

Article Gastroenterology & Hepatology

Comparison of Noninvasive Markers of Fibrosis in Patients With Nonalcoholic Fatty Liver Disease

Amy G. Shah et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2009)

Article Gastroenterology & Hepatology

Prediction of Non-Alcoholic Fatty Liver Disease and Liver Fat Using Metabolic and Genetic Factors

Anna Kotronen et al.

GASTROENTEROLOGY (2009)

Article Medicine, Research & Experimental

The Product of Fasting Glucose and Triglycerides As Surrogate for Identifying Insulin Resistance in Apparently Healthy Subjects

Luis E. Simental-Mendía et al.

Metabolic Syndrome and Related Disorders (2008)

Article Endocrinology & Metabolism

Appropriate waist circumference cutoff points for central obesity in Korean adults

Sang Yeoup Lee et al.

DIABETES RESEARCH AND CLINICAL PRACTICE (2007)

Review Gastroenterology & Hepatology

Insulin resistance: A metabolic pathway to chronic liver disease

E Bugianesi et al.

HEPATOLOGY (2005)

Article Gastroenterology & Hepatology

Serum lipids, lipoproteins and apolipoproteins levels in patients with nonalcoholic steatohepatitis

M Koruk et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2003)