Journal
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
Volume 781, Issue -, Pages 332-338Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jelechem.2016.09.053
Keywords
Ochratoxin A; Aptamer; Nanocomposites; Electrochemistry
Categories
Funding
- National Natural Science Foundation of China [21175061, 21375050, 21405063, 21505055]
- Natural Science Foundation of Jiangsu Province [BK20130481, BK20150486]
- Research Foundation of Jiangsu University [15JDG145]
- Priority Academic Program Development of Jiangsu Higher Education Institutions [PAPD-2014-37]
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Ochratoxin A (OTA) is one of the most toxic food contaminant mycotoxin, which can cause nephrotoxicity, teratogenicity, and carcinogenicity activity. Here an ultrasensitive electrochemical aptasensor for OTA was successfully fabricated. This aptasensor was constructed by combining nanocomposites of gold nanoparticles (AuNPs) functionalized silica-coated iron oxide magnetic nanoparticles (mSiO(2)@Au) and cadmium telluride quantum dots (CdTe QDs) modified graphene/AuNPs nanocomposites (GAu/CdTe). The as-prepared aptasensor exhibited a wide linear range (0.2 pg mL(-1) -4 ng mL(-1)), and an extremely low detection limit of 0.07 pg m(L-1) (S/N = 3). This work provides a novel strategy for the ultrasensitive detection of various target molecules and would have great potential in food safety monitoring and clinical diagnosis. (C) 2016 Elsevier B.V. All rights reserved.
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