4.7 Article

Protective Effect of Bilberry Anthocyanin Extracts on Dextran Sulfate Sodium-Induced Intestinal Damage in Drosophila melanogaster

Journal

NUTRIENTS
Volume 14, Issue 14, Pages -

Publisher

MDPI
DOI: 10.3390/nu14142875

Keywords

bilberry anthocyanin; Drosophila melanogaster; inflammatory bowel disease; antioxidant; intestinal microflora

Funding

  1. Science and Technology Development Project in Zhejiang, China [2019C02064]

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Bilberry anthocyanin extracts have protective effects against DSS-induced intestinal inflammation in a Drosophila melanogaster model, increasing survival rate, maintaining intestinal morphology, and reducing dead intestinal epithelial cells and ROS levels. Additionally, BANC supplementation improves antioxidant capacity by modulating NRF2 signaling pathways in the intestine.
Inflammatory bowel disease (IBD) is a chronic recurrent disease that can be controlled by various natural extracts. Anthocyanins (ANCs) from bilberry have significant antioxidant capacity and are widely used as food colors and antioxidants. In this study, we investigated the protective effects of bilberry anthocyanin extracts (BANCs) against dextran sulphate sodium (DSS)-induced intestinal inflammation in a Drosophila melanogaster (D. melanogaster) model, and the effects on the lifespan, antioxidant capacity, intestinal characteristics, and microbiome and gene expression profiles were analyzed to elucidate the underlying biological mechanisms. In DSS-induced normal and axenic D. melanogaster, BANCs significantly increased the survival rate, maintained the intestinal morphology and integrity, and reduced the number of dead intestinal epithelial cells and the ROS level of these cells. BANC supplementation had no significant effect on the intestinal microflora of DSS-induced D. melanogaster, as demonstrated by a 16S rDNA analysis, but improved the antioxidant capacity by activating the relative gene expression of NRF2 signaling pathways in the intestine of D. melanogaster with DSS-induced inflammation. Therefore, the results demonstrate that BANCs effectively alleviate intestinal inflammatory injury induced by DSS and improve the antioxidant capacity of D. melanogaster by modulating NRF2 signaling pathways, and could thus promote the application of BANCs as functional foods.

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