4.7 Review

Tea Polyphenols as Prospective Natural Attenuators of Brain Aging

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Interactions between dietary polyphenols and aging gut microbiota: A review

Sergio Davinelli et al.

Summary: Aging leads to significant changes in gut microbiota, including decreased microbial diversity, loss of commensals, and an increase in disease-associated pathobionts, which are accelerated by lifestyle factors. Polyphenols, found in fruits and vegetables, have emerged as promising anti-aging candidates due to their ability to modulate gut microbiota and produce bioactive compounds through gut bacteria metabolism. Evidence suggests that polyphenols have selective effects on the gut microbial community during aging.

BIOFACTORS (2022)

Article Biochemistry & Molecular Biology

Nuclear factor-kappa B (NF-ΚB) inhibition as a therapeutic target for plant nutraceuticals in mitigating inflammatory lung diseases

Khalid Saad Alharbi et al.

Summary: Nutraceuticals, as dietary supplements, have the potential to improve health, prevent diseases, and maintain normal body function. This review discusses the medical value of nutraceuticals in targeting the NF-kappa B pathway to mitigate inflammatory lung diseases.

CHEMICO-BIOLOGICAL INTERACTIONS (2022)

Review Food Science & Technology

Chemical constituents and biological properties of Pu-erh tea

Sunan Wang et al.

Summary: Pu-erh tea, a post-fermented tea native to Yunnan, China, is highly valued for its unique aroma, taste, and potential health benefits. While it is believed to have antioxidative, antimicrobial, and other activities, limited human trials have not convincingly demonstrated its therapeutic efficiency. Further research and quality improvement strategies are recommended.

FOOD RESEARCH INTERNATIONAL (2022)

Review Cell Biology

Telomere dysfunction in ageing and age-related diseases

Francesca Rossiello et al.

Summary: The article reviews the impact of telomere shortening and dysfunction on aging and a variety of age-related diseases in humans. Accumulation of senescent cells in aging organisms is believed to contribute to bodily dysfunction. Telomere shortening and damage are known causes of cellular senescence and aging. The authors argue that telomeric dysfunction plays a broad role in human pathologies associated with normal aging.

NATURE CELL BIOLOGY (2022)

Review Geriatrics & Gerontology

Recent Neurotherapeutic Strategies to Promote Healthy Brain Aging: Are we there yet?

Chul-Kyu Kim et al.

Summary: Due to the exponential increase in global population ageing, there is an urgent need to develop reliable strategies to slow down and delay the ageing process. Although candidate drugs and strategies have been developed to improve brain ageing, clinical evidence is limited and further research is needed to determine their long-term efficacy and lack of adverse effects.

AGING AND DISEASE (2022)

Review Cell Biology

Microbiota-microglia connections in age-related cognition decline

Rui Zhou et al.

Summary: Aging affects gut microbiota compositions, microglia, and cognition abilities, and is recognized as a risk factor for neurodegenerative diseases. The communication between gut microbiota and microglia plays a crucial role in age-related cognitive declines. This review discusses the changes in gut microbiota compositions, brain changes, especially morphology and functions of microglia, and highlights the role of microbiota-microglia connections in neurodegenerative diseases.

AGING CELL (2022)

Article Marine & Freshwater Biology

Tea polyphenols alleviates acetochlor-induced apoptosis and necroptosis via ROS/MAPK/NF-κB signaling in Ctenopharyngodon idellus kidney cells

Xia Zhao et al.

Summary: The present study demonstrates the effects of acetochlor exposure on fish cells, including oxidative stress, mitochondrial damage, lactate accumulation, and cell death. However, tea polyphenols can alleviate these issues and protect cells from oxidative stress.

AQUATIC TOXICOLOGY (2022)

Review Food Science & Technology

A comprehensive review on the prevention and regulation of Alzheimer's disease by tea and its active ingredients

Yi Huang et al.

Summary: Alzheimer's disease is a representative neurodegenerative disease that has imposed a heavy burden on society. The active ingredients in tea have potential in preventing and regulating the pathogenesis of Alzheimer's disease.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

Article Environmental Sciences

Investigation of nickel sulfate-induced cytotoxicity and underlying toxicological mechanisms in human umbilical vein endothelial cells through oxidative stress, inflammation, apoptosis, and MAPK signaling pathways

Yanli Liu et al.

Summary: Nickel and its compounds can inhibit cell growth, induce oxidative stress, inflammation, and apoptosis responses, possibly mediated through the P38 and JNK MAPK stress response pathways.

ENVIRONMENTAL TOXICOLOGY (2022)

Review Biochemistry & Molecular Biology

The neuroprotective effects of intermittent fasting on brain aging and neurodegenerative diseases via regulating mitochondrial function

Yihang Zhao et al.

Summary: This review focuses on the mechanisms by which intermittent fasting (IF) improves mitochondrial function in brain aging and neurodegenerative diseases such as Alzheimer's, Parkinson's, and Huntington's. IF activates adaptive cellular stress responses and signaling pathways, enhancing mitochondrial function by promoting energy metabolism and reducing oxidant production.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

Article Cell Biology

Recycling of autophagosomal components from autolysosomes by the recycler complex

Chuchu Zhou et al.

Summary: This study reveals a process called autophagosomal components recycling (ACR) and identifies the SNX4-SNX5-SNX17 complex that mediates the recycling of autophagosomal components from autolysosomes.

NATURE CELL BIOLOGY (2022)

Article Neurosciences

Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

Ju-Hyun Lee et al.

Summary: This study reveals unique autophagy dysregulation within neurons in Alzheimer's disease mouse models, particularly deficient autolysosome acidification, leading to the accumulation of autophagic vacuoles and the formation of flower-like structures called "PANTHOS," which may contribute to the development of senile plaques in Alzheimer's disease.

NATURE NEUROSCIENCE (2022)

Article Neurosciences

Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N-6-carboxymethyllysine

Omar Mossad et al.

Summary: This study reveals that the gut microbiota plays a role in age-related changes in microglial gene expression and function. The absence of gut microbiota improves oxidative stress and mitochondrial dysfunction in microglia from aging brains. Additionally, the accumulation of N-6-carboxymethyllysine (CML) in microglia leads to increased reactive oxygen species and impaired mitochondrial activity and ATP reservoirs. These findings provide insights into the regulation of microglial features by the gut microbiota in aged mice and humans.

NATURE NEUROSCIENCE (2022)

Review Biochemistry & Molecular Biology

Gangliosides play important roles in the nervous system by regulating ion concentrations

Yijia Xu et al.

Summary: Gangliosides are crucial components of neuronal cell membranes, playing a vital role in neuronal and brain development. They are involved in neurotransmission and considered as the structural foundation of learning and memory. Gangliosides also participate in various physiological processes, including cell differentiation, cell signaling, neuroprotection, nerve regeneration, and cell apoptosis. The regulation of ion concentration by gangliosides is important in neurological diseases, highlighting their role in neuronal excitability and synaptic transmission. Therefore, understanding the role of gangliosides in maintaining ion concentration homeostasis is essential for their potential use as drugs for treating nervous system diseases.

NEUROCHEMICAL RESEARCH (2022)

Editorial Material Multidisciplinary Sciences

Microbiota-brain axis: Context and causality

Ohn F. Cryan et al.

SCIENCE (2022)

Article Multidisciplinary Sciences

Bacterial sensing via neuronal Nod2 regulates appetite and body temperature

Ilana Gabanyi et al.

Summary: Gut bacteria can influence feeding behavior and body temperature control by directly sensing bacterial cell wall components through brain neurons.

SCIENCE (2022)

Review Microbiology

Mechanisms Underlying the Interaction Between Chronic Neurological Disorders and Microbial Metabolites via Tea Polyphenols Therapeutics

Mengyu Hong et al.

Summary: The hydroxyl groups and characteristic structural groups in tea polyphenols provide them with antioxidant activity, leading to anti-inflammatory effects and protection of intestinal flora and brain neurons. Microbial metabolites associated with the host have been identified as major regulators of the central nervous system. Studies on metabolites such as serotonin and short-chain fatty acids have identified multiple signaling pathways relevant to host health. However, the complexity and limitations of translating complex human diseases into animal models remain challenges. This article discusses several intestinal metabolites with research value, highlighting the interaction between tea polyphenols and chronic brain diseases mediated by the microbiota.

FRONTIERS IN MICROBIOLOGY (2022)

Article Microbiology

Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

Aimee Parker et al.

Summary: This study demonstrates that changes in the gut microbiota are associated with age-related chronic diseases, particularly inflammation affecting the brain and retina. Fecal microbiota transplantation can alter the gut microbiota composition and metabolic pathways. Transferring aged donor microbiota into young mice accelerates age-associated inflammation in the central nervous system and retina, along with increased intestinal barrier permeability, while transferring young donor microbiota reverses these effects.

MICROBIOME (2022)

Article Food Science & Technology

Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases

Van-Long Truong et al.

Summary: Polyphenols, including phenolic acids, flavonoids, and procyanidins, are abundant in food and beverage derived from plants. Tea polyphenols have established antioxidant and anti-inflammatory properties, and their supplementation can prevent inflammatory conditions and improve the outcome of patients with inflammatory bowel diseases (IBD).

FOOD SCIENCE AND HUMAN WELLNESS (2022)

Article Chemistry, Applied

EGCG attenuates the neurotoxicity of methylglyoxal via regulating MAPK and the downstream signaling pathways and inhibiting advanced glycation end products formation

Yin He et al.

Summary: This study found that EGCG can attenuate MGO-induced nerve damage by regulating MAPK and downstream pathways, as well as inhibiting the formation of AGEs.

FOOD CHEMISTRY (2022)

Review Food Science & Technology

Potential implications of polyphenols on aging considering oxidative stress, inflammation, autophagy, and gut microbiota

Min Wu et al.

Summary: Polyphenols, as natural compounds derived from plants, have attracted increasing scientific interest for their potential anti-aging benefits in modulating oxidative damage, inflammation, autophagy, and gut microbiota. Research on novel polyphenol-based strategies and clinical trials are encouraged for the development of holistic anti-aging therapy.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2021)

Review Biochemistry & Molecular Biology

Telomeres: history, health, and hallmarks of aging

Deepavali Chakravarti et al.

Summary: The escalating social and economic burden of an aging world population has brought aging research into the spotlight. Through the lens of telomere biology, we can better understand the mechanisms of aging and the development of age-related diseases, providing insights for prevention and treatment.
Article Geriatrics & Gerontology

Tea polyphenols ameliorates memory decline in aging model rats by inhibiting brain TLR4/NF-κB inflammatory signaling pathway caused by intestinal flora dysbiosis

Chenmeng Song et al.

Summary: Tea polyphenols were found to improve memory decline in aging model rats by regulating intestinal flora to alleviate brain inflammation. High dose of TP (300 mg/kg) had a more significant improvement on rat behavior, intestinal flora composition, intestinal epithelium morphology and function.

EXPERIMENTAL GERONTOLOGY (2021)

Review Cell Biology

NAD+ metabolism and its roles in cellular processes during ageing

Anthony J. Covarrubias et al.

Summary: NAD(+) is a crucial coenzyme in redox reactions and plays a pivotal role in energy metabolism. Its levels decline with age, and raising NAD(+) levels is being explored as a potential strategy to extend human lifespan and healthspan. NAD(+) influences key cellular processes and functions, including metabolic pathways, DNA repair, and cellular senescence, with implications for healthy aging and age-related diseases.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Review Neurosciences

Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions

Csaba Cserep et al.

Summary: Microglia establishing direct contact with neurons play a crucial role in regulating neuronal responses and fate, contributing significantly to brain diseases.

NEURON (2021)

Article Cell Biology

Tea Polyphenol Attenuates Oxidative Stress-Induced Degeneration of Intervertebral Discs by Regulating the Keap1/Nrf2/ARE Pathway

Dawei Song et al.

Summary: This study demonstrated that tea polyphenols can protect nucleus pulposus cells and delay their degeneration by activating the Keap1/Nrf2/ARE pathway.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Cell Biology

Brain aging mechanisms with mechanical manifestations

Yana Blinkouskaya et al.

Summary: Brain aging is a complex process that involves morphological and pathophysiological changes, with increasing interest in biomechanical modeling. The integration of imaging and mechanical modeling may help identify the tipping point between normal aging and pathological neurodegeneration.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

Review Chemistry, Analytical

Metabolomics analysis of microbiota-gut-brain axis in neurodegenerative and psychiatric diseases

Marcela Konjevod et al.

Summary: The gut microbiota plays a crucial role in influencing host health and has been linked to various neurodegenerative and neuropsychiatric disorders. Genetic predisposition and environmental triggers also play a role in the development of these complex diseases, making it important to target gut microbiota metabolites to understand the impact of gut-brain axis imbalance on human health.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)

Review Psychiatry

Understanding the Connection Between the Gut-Brain Axis and Stress/Anxiety Disorders

Younjung Lee et al.

Summary: The microbiota-gut-brain axis involves a bidirectional relationship between the brain and gastrointestinal organs, with onset of anxiety disorders possibly correlated with this mechanism. There is a potential for using gastrointestinal system drugs such as probiotics and antibiotics as treatments for anxiety disorders. New strategies employing the microbiota-gut-brain axis mechanism are expected to be developed for not only anxiety disorders, but also other psychiatric diseases.

CURRENT PSYCHIATRY REPORTS (2021)

Article Food Science & Technology

Tea polyphenols improve the memory in aging ovariectomized rats by regulating brain glucose metabolism in vivo and in vitro

Luping Zhang et al.

Summary: Our study demonstrated that tea polyphenols can improve memory in aging ovariectomized rats by regulating brain glucose metabolism, suggesting a potential anti-aging effect.

JOURNAL OF FUNCTIONAL FOODS (2021)

Review Biochemistry & Molecular Biology

Dietary Anti-Aging Polyphenols and Potential Mechanisms

Jing Luo et al.

Summary: Polyphenols have beneficial effects on health, anti-aging through various mechanisms, and may prevent aging-related diseases. Exploring the potential benefits of combinations of multiple polyphenols or polyphenol-rich foods is recommended.

ANTIOXIDANTS (2021)

Review Biochemistry & Molecular Biology

Energy, Entropy and Quantum Tunneling of Protons and Electrons in Brain Mitochondria: Relation to Mitochondrial Impairment in Aging-Related Human Brain Diseases and Therapeutic Measures

James P. Bennett et al.

Summary: The adult human brain consumes a disproportionate amount of energy substrates, with ATP being the universal energy currency. Neurodegenerative diseases may result from factors such as stress damage, genetic mutations, epigenetic modifications, and mitochondrial dysfunction. Mitochondrial therapeutics aims to correct deficiencies in energy production processes.

BIOMEDICINES (2021)

Review Neurosciences

Brain-Derived Neurotrophic Factor Signaling in Depression and Antidepressant Action

Eero Castren et al.

Summary: Neurotrophic factors, especially BDNF, are associated with depression and the action of antidepressant drugs, with impaired BDNF signaling linked to mood disorders. Increased BDNF expression and signaling have been linked to the mechanisms of antidepressant drugs, and BDNF regulates various types of neuronal plasticities in the brain, which are connected to antidepressant action. The hypothesis of a connection between neurotrophic factors and neuronal plasticity with mood disorders and antidepressant action has been further supported by recent evidence.

BIOLOGICAL PSYCHIATRY (2021)

Review Food Science & Technology

Role of dietary polyphenols on gut microbiota, their metabolites and health benefits

S. Mithul Aravind et al.

Summary: In the past two decades, there has been intensive research on the beneficial health roles of dietary polyphenols in preventing oxidative stress related chronic diseases. As our understanding of the role of gut microbiota advances, the need to examine the prebiotic role of dietary polyphenols has emerged. Further research should focus on the importance of human trials and the links of polyphenols-gut microbiota-nerve-brain to unlock the mechanisms behind the observed benefits of dietary polyphenols.

FOOD RESEARCH INTERNATIONAL (2021)

Article Biochemistry & Molecular Biology

Epigallocatechin-3-Gallate-Loaded Liposomes Favor Anti-Inflammation of Microglia Cells and Promote Neuroprotection

Chun-Yuan Cheng et al.

Summary: The use of EGCG-loaded liposomes can effectively inhibit neuroinflammation induced by LPS, protect neurons, and improve motor impairment. This treatment approach has the potential to be a valuable candidate for disease-modifying therapy for Parkinson's disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

The Role of NRF2/KEAP1 Signaling Pathway in Cancer Metabolism

Moon-Young Song et al.

Summary: NRF2 and KEAP1 are crucial regulators of redox homeostasis, and their signaling pathway is associated with cancer cell proliferation and tumorigenesis. Modulating this pathway may serve as a novel therapeutic strategy for cancer treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Multidisciplinary Sciences

The central role of DNA damage in the ageing process

Bjoern Schumacher et al.

Summary: Ageing is a complex process that affects every organ and tissue in the body, but the causal mechanism behind it remains unclear. Accumulating evidence suggests that DNA damage may play a central role in driving ageing, providing a potential unified approach to combat age-related diseases.

NATURE (2021)

Article Medicine, Research & Experimental

Reversal of brain aging by targeting telomerase: A nutraceutical approach

Dimitris Tsoukalas et al.

Summary: The study found that the 'Reverse(TM)' supplement can promote telomerase activity and TERT expression in the brains of middle-aged rats, which may contribute to alleviating central nervous system diseases.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

Article Neurosciences

Neural Mechanism of Shentai Tea Polyphenols on Cognitive Improvements for Individuals with Subjective Cognitive Decline: A Functional Near-Infrared Spectroscopy Study

Lianghui Ni et al.

Summary: This study investigated the neural mechanism of shentai tea polyphenols in subjects with subjective cognitive decline (SCD) using fNIRS and found increased brain activity in specific regions after intervention, leading to improved cognitive functions and depression symptoms. The results suggest important implications for utilizing shentai tea polyphenols interventions in SCD.

JOURNAL OF ALZHEIMERS DISEASE (2021)

Article Oncology

KEAP1/NRF2 (NFE2L2) mutations in NSCLC-Fuel for a superresistant phenotype?

Wolfram C. M. Dempke et al.

Summary: NRF2 is the master regulator of cellular antioxidant responses and dysregulation of the KEAP1/NRF2 axis is associated with various diseases. Oxidative stress plays a crucial role in chronic diseases, particularly in NSCLC patients.

LUNG CANCER (2021)

Review Biochemistry & Molecular Biology

Green Tea and Its Relation to Human Gut Microbiome

Sergio Perez-Burillo et al.

Summary: Green tea can influence gut microbiota by either stimulating the growth of specific species or hindering the development of detrimental ones, benefiting health through beneficial bacteria or microbial bioactive metabolites. The inter-relation between green tea and gut microbiota is crucial for many health promoting effects of green tea, with the ability to correct microbial dysbiosis in conditions like obesity or cancer. Tea compounds influence the growth of bacterial species involved in inflammatory processes, potentially impacting the development of chronic diseases.

MOLECULES (2021)

Review Cell Biology

Natural Products for Neurodegeneration: Regulating Neurotrophic Signals

Md Sahab Uddin et al.

Summary: Neurodegenerative disorders are characterized by progressive damage of the nervous system. Phytochemicals, especially polyphenols, play a crucial role in neuroprotection due to their anti-inflammatory, antioxidative, and antiamyloidogenic effects. Maintaining neurotrophin levels is important for neuroprotection.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Review Neurosciences

The Microbiota-Gut-Brain Axis in Health and Disease and Its Implications for Translational Research

Melanie Anna Schaechtle et al.

Summary: In the past few decades, microbiome research has rapidly evolved, revealing the significant role of microbiota in shaping mammalian physiology, particularly in relation to the brain. The discovery of the gut-brain axis further emphasized the importance of bidirectional communication between gut microbiota and the nervous system, shedding light on the pathogenesis of various neurological and psychiatric disorders.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Review Neurosciences

The Relationship Between the Gut Microbiome and Neurodegenerative Diseases

Xueling Zhu et al.

Summary: The relationship between gut microbiome and neurodegenerative diseases remains unclear, but research is gradually revealing some connections. With technological advancements, new techniques for studying the microbiome will be developed and refined, potentially offering new possibilities for disease treatment.

NEUROSCIENCE BULLETIN (2021)

Review Gastroenterology & Hepatology

Effects of anti-aging interventions on intestinal microbiota

Yanjiao Du et al.

Summary: Identifying ways to deal with the challenges of aging is crucial, with external factors like diet, exercise, and drug therapy, along with the intestinal microbiota, playing key roles in healthy aging. By regulating the homeostasis of intestinal flora and promoting a healthy intestinal environment, interventions based on intestinal microorganisms show great potential in combating aging and age-related diseases.

GUT MICROBES (2021)

Article Cell Biology

Microbiota from young mice counteracts selective age-associated behavioral deficits

Marcus Boehme et al.

Summary: The study demonstrates that rejuvenation of the gut microbiome by fecal microbiota transplantation from young mice can reverse aging-induced differences in the immune system, metabolome, and transcriptome, and improve specific cognitive deficits.

NATURE AGING (2021)

Review Agriculture, Multidisciplinary

Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation

Diogo Carregosa et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

Review Pharmacology & Pharmacy

Mechanisms of aging and potential role of selected polyphenols in extending healthspan

Gian Luigi Russo et al.

BIOCHEMICAL PHARMACOLOGY (2020)

Review Biotechnology & Applied Microbiology

Modulation effect of tea consumption on gut microbiota

Yu-Chuan Liu et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Article Nutrition & Dietetics

Beta-carotene, telomerase activity and Alzheimer's disease in old age subjects

Virginia Boccardi et al.

EUROPEAN JOURNAL OF NUTRITION (2020)

Review Cell Biology

Protecting the Aging Genome

Michael A. Petr et al.

TRENDS IN CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway

Dan He et al.

NATURE COMMUNICATIONS (2020)

Review Agriculture, Multidisciplinary

Gut Microbiota: A Pivotal Hub for Polyphenols as Antidepressants

Nian Zhou et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2020)

Review Biochemistry & Molecular Biology

Ageing, metabolism and the intestine

Maja C. Funk et al.

EMBO REPORTS (2020)

Review Microbiology

The Gut Microbiota and Unhealthy Aging: Disentangling Cause from Consequence

Erica N. DeJong et al.

CELL HOST & MICROBE (2020)

Review Biochemistry & Molecular Biology

Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease

Estefania de Gregorio et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Interrelation between ROS and Ca2+ in aging and age-related diseases

Corina T. Madreiter-Sokolowski et al.

REDOX BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Neuroprotective Properties of Green Tea (Camellia sinensis) in Parkinson's Disease: A Review

Dicson Sheeja Malar et al.

MOLECULES (2020)

Article Multidisciplinary Sciences

Gut-educated IgA plasma cells defend the meningeal venous sinuses

Zachary Fitzpatrick et al.

NATURE (2020)

Review Neurosciences

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

D. Allan Butterfield et al.

NATURE REVIEWS NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

A subtelomeric region affects telomerase-negative replicative senescence in Saccharomyces cerevisiae

Pascale Jolivet et al.

SCIENTIFIC REPORTS (2019)

Review Biochemistry & Molecular Biology

Function of Green Tea Catechins in the Brain: Epigallocatechin Gallate and its Metabolites

Monira Pervin et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Multidisciplinary Sciences

From discoveries in ageing research to therapeutics for healthy ageing

Judith Campisi et al.

NATURE (2019)

Review Cell Biology

Intestinal epithelial barrier functions in ageing

Jacopo J. V. Branca et al.

AGEING RESEARCH REVIEWS (2019)

Review Cell Biology

NAD+ in Brain Aging and Neurodegenerative Disorders

Sofie Lautrup et al.

CELL METABOLISM (2019)

Review Plant Sciences

What is responsible for antioxidant properties of polyphenolic compounds from plants?

Malgorzata Olszowy

PLANT PHYSIOLOGY AND BIOCHEMISTRY (2019)

Review Food Science & Technology

Ginsenosides, catechins, quercetin and gut microbiota: Current evidence of challenging interactions

Rosaria Santangelo et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

Article Biochemistry & Molecular Biology

Chronic inflammation in the etiology of disease across the life span

David Furman et al.

NATURE MEDICINE (2019)

Review Nutrition & Dietetics

Tea Polyphenols in Promotion of Human Health

Naghma Khan et al.

NUTRIENTS (2019)

Review Biochemistry & Molecular Biology

The effects of polyphenols and other bioactives on human health

Cesar G. Fraga et al.

FOOD & FUNCTION (2019)

Review Biochemistry & Molecular Biology

The role of mitochondrial ROS in the aging brain

Rhoda Stefanatos et al.

FEBS LETTERS (2018)

Editorial Material Oncology

JNK, p38, ERK, and SGK1 Inhibitors in Cancer

Jonas Cicenas et al.

CANCERS (2018)

Review Biochemistry & Molecular Biology

Nrf2-Keap1 signaling in oxidative and reductive stress

Ilaria Bellezza et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)

Review Cell Biology

Metabolic regulation of the PMCA: Role in cell death and survival

Jason I. E. Bruce

CELL CALCIUM (2018)

Review Cardiac & Cardiovascular Systems

Reactive Oxygen Species in Metabolic and Inflammatory Signaling

Steven J. Forrester et al.

CIRCULATION RESEARCH (2018)

Article Biochemistry & Molecular Biology

Impact of Long-Term RF-EMF on Oxidative Stress and Neuroinflammation in Aging Brains of C57BL/6 Mice

Ye Ji Jeong et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Biochemistry & Molecular Biology

Regulation of autophagy by tea polyphenols in diabetic cardiomyopathy

Hui Zhou et al.

JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B (2018)

Article Neurosciences

Accelerated aging and aging process in the brain

Nickolay K. Isaev et al.

REVIEWS IN THE NEUROSCIENCES (2018)

Review Pharmacology & Pharmacy

Anti-neuroinflammatory Potential of Natural Products in Attenuation of Alzheimer's Disease

Bushra Shal et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Genetics & Heredity

NF-kappaB: Two Sides of the Same Coin

Bruno R. B. Pires et al.

GENES (2018)

Article Multidisciplinary Sciences

High-avidity IgA protects the intestine by enchaining growing bacteria

Kathrin Moor et al.

NATURE (2017)

Review Cell Biology

Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy

Tuane Bazanella Sampaio et al.

NEURAL REGENERATION RESEARCH (2017)

Review Biochemistry & Molecular Biology

NAD+ in Aging: Molecular Mechanisms and Translational Implications

Evandro F. Fang et al.

TRENDS IN MOLECULAR MEDICINE (2017)

Review Neurosciences

Preventive and Protective Roles of Dietary Nrf2 Activators Against Central Nervous System Diseases

Yang Sun et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2017)

Review Anesthesiology

NGF/TrkA Signaling as a Therapeutic Target for Pain

Munetaka Hirose et al.

PAIN PRACTICE (2016)

Review Cell Biology

Brain atrophy in Alzheimer's Disease and aging

Lorenzo Pini et al.

AGEING RESEARCH REVIEWS (2016)

Review Medicine, Research & Experimental

Protective role of epigallocatechin-3-gallate in health and disease: A perspective

Animesh Chowdhury et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

Article Neurosciences

Are Polyphenols Strong Dietary Agents Against Neurotoxicity and Neurodegeneration?

Susana Almeida et al.

NEUROTOXICITY RESEARCH (2016)

Review Cell Biology

From cellular senescence to Alzheimer's disease: The role of telomere shortening

Virginia Boccardi et al.

AGEING RESEARCH REVIEWS (2015)

Article Biochemistry & Molecular Biology

Protective action of green tea catechins in neuronal mitochondria during aging

Marco Assuncao et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2015)

Article Clinical Neurology

Biochemical and Histopathological Effects of Catechin on Experimental Peripheral Nerve Injuries

Ali Erdem Yildirim et al.

TURKISH NEUROSURGERY (2015)

Article Biochemistry & Molecular Biology

Green tea catechins potentiate the neuritogenic action of brain-derived neurotrophic factor: Role of 67-kDa laminin receptor and hydrogen peroxide

Usha Gundimeda et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)

Review Neurosciences

Polyunsaturated fatty acids and their metabolites in brain function and disease

Richard P. Bazinet et al.

NATURE REVIEWS NEUROSCIENCE (2014)

Article Chemistry, Medicinal

Effect of green tea and its polyphenols on mouse liver

Ibrahim G. Saleh et al.

FITOTERAPIA (2013)

Review Endocrinology & Metabolism

Phytochemicals suppress nuclear factor-κB signaling: impact on health span and the aging process

Antero Salminen et al.

CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2012)

Review Chemistry, Medicinal

Effects of Tea Polyphenols and their Polymers on MAPK Signaling Pathways in Cancer Research

W. Li et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2012)

Article Medicine, Research & Experimental

EGCG inhibits Tat-induced LTR transactivation: Role of Nrf2, AKT, AMPK signaling pathway

Hong-Sheng Zhang et al.

LIFE SCIENCES (2012)

Review Biochemistry & Molecular Biology

The Role of Bioactive Compounds on the Promotion of Neurite Outgrowth

Sandeep Vasant More et al.

MOLECULES (2012)

Article Pharmacology & Pharmacy

Green tea catechin, epigallocatechin-3-gallate (EGCG): Mechanisms, perspectives and clinical applications

Brahma N. Singh et al.

BIOCHEMICAL PHARMACOLOGY (2011)

Review Biochemistry & Molecular Biology

Brain aging, Alzheimer's disease, and mitochondria

Russell H. Swerdlow

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)

Review Biochemistry & Molecular Biology

Effect of Polyphenols on Oxidative Stress and Mitochondrial Dysfunction in Neuronal Death and Brain Edema in Cerebral Ischemia

Kiran S. Panickar et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2011)

Article Food Science & Technology

Hepatotoxicity of high oral dose (-)-epigallocatechin-3-gallate in mice

Joshua D. Lambert et al.

FOOD AND CHEMICAL TOXICOLOGY (2010)

Review Biochemistry & Molecular Biology

A Review of the Antioxidant Mechanisms of Polyphenol Compounds Related to Iron Binding

Nathan R. Perron et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2009)

Article Nutrition & Dietetics

Tea consumption and cognitive impairment and decline in older Chinese adults

Tze-Pin Ng et al.

AMERICAN JOURNAL OF CLINICAL NUTRITION (2008)

Review Neurosciences

Small molecule activators of the Trk receptors for neuroprotection

Nicholas J. G. Webster et al.

BMC NEUROSCIENCE (2008)

Article Food Science & Technology

Safety studies on epigallocatechin gallate (EGCG) preparations. Part 2: Dermal, acute and short-term toxicity studies

R. A. Isbrucker et al.

FOOD AND CHEMICAL TOXICOLOGY (2006)

Review Biochemistry & Molecular Biology

Neurological mechanisms of green tea polyphenols in Alzheimer's and Parkinson's diseases

O Weinreb et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2004)

Article Medicine, General & Internal

The dementias

K Ritchie et al.

LANCET (2002)