Journal
MATERIALS
Volume 15, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/ma15144752
Keywords
antibiotics-loaded sol-gel coatings; AFM; SEM; solid-state Si-29-NMR spectroscopy; Fourier-transform infrared spectroscopy
Categories
Funding
- Regional Government of Madrid through the program ADITIMAT [P2018/NMT-4411]
- CIBERINFEC-CIBER of Infectious Diseases [CB21/13/00043]
- Spanish Ministry of Education, Culture, and Sports through FPU grant [FPU17/05977]
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In this study, biodegradable sol-gel coatings were investigated as a carrier for preventing infection in joint prostheses. The coatings showed microscale roughness, but no evidence of chemical bonding between antibiotics and the siloxane network.
Infection is one of the most common causes that leads to joint prosthesis failure. In the present work, biodegradable sol-gel coatings were investigated as a promising controlled release of antibiotics for the local prevention of infection in joint prostheses. Accordingly, a sol-gel formulation was designed to be tested as a carrier for 8 different individually loaded antimicrobials. Sols were prepared from a mixture of MAPTMS and TMOS silanes, tris(tri-methylsilyl)phosphite, and the corresponding antimicrobial. In order to study the cross-linking and surface of the coatings, a battery of examinations (Fourier-transform infrared spectroscopy, solid-state Si-29-NMR spectroscopy, thermogravimetric analysis, SEM, EDS, AFM, and water contact angle, thickness, and roughness measurements) were conducted on the formulations loaded with Cefoxitin and Linezolid. A formulation loaded with both antibiotics was also explored. Results showed that the coatings had a microscale roughness attributed to the accumulation of antibiotics and organophosphites in the surface protrusions and that the existence of chemical bonds between antibiotics and the siloxane network was not evidenced.
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