Simultaneous Substitution of Fe and Sr in Beta-Tricalcium Phosphate: Synthesis, Structural, Magnetic, Degradation, and Cell Adhesion Properties

beta-tricalcium phosphate is a promising bone graft substitute material with biocompatibility and high osteoinductivity. However, research on the ideal degradation and absorption for better clinical application remains a challenge. Now, we focus on modifying physicochemical properties and improving biological properties through essential ion co-substitution (Fe and Sr) in beta-TCPs. Fe- and Sr-substituted and Fe/Sr co-substituted beta-TCP were synthesized by aqueous co-precipitation with substitution levels ranging from 0.2 to 1.0 mol%. The beta-TCP phase was detected by X-ray diffraction and Fourier transform infrared spectroscopy. Changes in Ca-O and P-O bond lengths of the co-substituted samples were observed through X-ray photoelectron spectroscopy. The results of VSM represent the M-H graph having a combination of diamagnetic and ferromagnetic properties. A TRIS-HCl solution immersion test showed that the degradation and resorption functions act synergistically on the surface of the co-substituted sample. Cell adhesion tests demonstrated that Fe enhances the initial adhesion and proliferation behavior of hDPSCs. The present work suggests that Fe and Sr co-substitution in beta-TCP can be a candidate for promising bone graft materials in tissue engineering fields. In addition, the possibility of application of hyperthermia for cancer treatment can be expected.

Automated summary

The study focuses on modifying physicochemical and biological properties of beta-TCP through essential ion co-substitution (Fe and Sr), results show changes in Ca-O and P-O bond lengths of the co-substituted samples, VSM exhibits a combination of diamagnetic and ferromagnetic properties, TRIS-HCl solution immersion test demonstrates synergistic degradation and resorption functions on the surface of the substituted sample, cell adhesion tests reveal that Fe enhances the initial adhesion and proliferation behavior of hDPSCs.