4.5 Article

On the role of metaheuristic optimization in bioinformatics

Journal

INTERNATIONAL TRANSACTIONS IN OPERATIONAL RESEARCH
Volume 30, Issue 6, Pages 2909-2944

Publisher

WILEY
DOI: 10.1111/itor.13164

Keywords

metaheuristics; bioinformatics; combinatorial optimization

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This paper discusses the application of metaheuristic algorithms in solving optimization problems in the field of bioinformatics, focusing on molecular docking, protein structure prediction, phylogenetic inference, and string problems.
Metaheuristic algorithms are employed to solve complex and large-scale optimization problems in many different fields, from transportation and smart cities to finance. This paper discusses how metaheuristic algorithms are being applied to solve different optimization problems in the area of bioinformatics. While the text provides references to many optimization problems in the area, it focuses on those that have attracted more interest from the optimization community. Among the problems analyzed, the paper discusses in more detail the molecular docking problem, the protein structure prediction, phylogenetic inference, and different string problems. In addition, references to other relevant optimization problems are also given, including those related to medical imaging or gene selection for classification. From the previous analysis, the paper generates insights on research opportunities for the Operations Research and Computer Science communities in the field of bioinformatics.

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