Journal
BIOMEDICAL OPTICS EXPRESS
Volume 13, Issue 9, Pages 4970-4989Publisher
Optica Publishing Group
DOI: 10.1364/BOE.460737
Keywords
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Funding
- Xstrahl Ltd
- Cancer Prevention and Research Institute of Texas [RR200042]
- National Cancer Institute [P30CA006973, R01CA240811, R21CA223403, R37CA230341]
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This study presents a novel mobile bioluminescence tomography (BLT) system for a small animal irradiator to accurately localize soft tissue targets for radiation guidance. The system demonstrates high accuracy in target localization, providing a distinctive opportunity for investigators to perform conformal biology-guided irradiation to malignancy.
Due to low imaging contrast, a widely-used cone-beam computed tomography-guided small animal irradiator is less adept at localizing in vivo soft tissue targets. Bioluminescence tomography (BLT), which combines a model of light propagation through tissue with an optimization algorithm, can recover a spatially resolved tomographic volume for an internal bioluminescent source. We built a novel mobile BLT system for a small animal irradiator to localize soft tissue targets for radiation guidance. In this study, we elaborate its configuration and features that are indispensable for accurate image guidance. Phantom and in vivo validations show the BLT system can localize targets with accuracy within 1 mm. With the optimal choice of threshold and margin for target volume, BLT can provide a distinctive opportunity for investigators to perform conformal biology-guided irradiation to malignancy.(c) 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing Agreement
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