En-face polarization-sensitive optical coherence tomography to characterize early-stage esophageal cancer and determine tumor margin

Current imaging tools are insufficiently sensitive to the early diagnosis of esophageal squamous cell carcinoma (ESCC). The application of polarization-sensitive optical coherence tomography (PS-OCT) to detect tumor-stroma interaction is an interesting issue in cancer diagnosis. In this translational study, we found that en-face PS-OCT effectively characterizes protruding, flat, and depressive type ESCC regardless of animal or human specimens. In addition, the tumor contour and margin could also be drawn and determined on a broad en-face view. The determined tumor margin could be in the proximity of 2 mm to the actual tumor margin, which was proved directly using histology.

Automated summary

Polarization-sensitive optical coherence tomography (PS-OCT) has shown effectiveness in diagnosing esophageal squamous cell carcinoma (ESCC) with high accuracy, regardless of animal or human specimens. It can draw and determine the contour and margin of the tumor, which is consistent with the histology results.