Measurement and modeling of metoclopramide hydrochloride (anti-emetic drug) solubility in supercritical carbon dioxide

Knowledge of drug solubility data in supercritical carbon dioxide (SC-CO2) is a fundamental step in producing nano and microparticles through supercritical fluid technology. In this work, for the first time, the solubility of metoclopramide hydrochloride (MCP) in SC-CO2 was measured in pressure and temperature range of 12 to 27 MPa and 308 to 338 K, respectively. The results represented a range mole fractions of 0.15 x 10(-5) to 5.56 x 10(-5). To expand the application of the obtained data, six semi-empirical models and three models based on the Peng-Robinson equation of state (PR + VDW, PR + WS + Wilson and PR + MHV1 + COSMOSAC) with different mixing rules and various ways to describe intermolecular interactions were investigated. Furthermore, total enthalpy, sublimation enthalpy and solvation enthalpy relevant to MCP solvating in SC-CO2 were estimated. (c) 2022 The Authors. Published by Elsevier B.V. on behalf of King Saud University.

Automated summary

Understanding the solubility of drugs in supercritical carbon dioxide is crucial for producing nanoparticles and microparticles using supercritical fluid technology. This study measured the solubility of metoclopramide hydrochloride in SC-CO2 and estimated the enthalpy changes during the solvation process. Additionally, different models were investigated to expand the use of the obtained data.