The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases

Evidence from human cohorts indicates that chronic insomnia is associated with higher risk of cardiometabolic diseases (CMD), yet whether gut microbiota plays a role is unclear. Here, in a longitudinal cohort (n = 1809), we find that the gut microbiota-bile acid axis may link the positive association between chronic insomnia and CMD. Ruminococcaceae UCG-002 and Ruminococcaceae UCG-003 are the main genera mediating the positive association between chronic insomnia and CMD. These results are also observed in an independent cross-sectional cohort (n = 6122). The inverse associations between those gut microbial biomarkers and CMD are mediated by certain bile acids (isolithocholic acid, muro cholic acid and nor cholic acid). Habitual tea consumption is prospectively associated with the identified gut microbiota and bile acids in an opposite direction compared with chronic insomnia. Our work suggests that microbiota-bile acid axis may be a potential intervention target for reducing the impact of chronic insomnia on cardiometabolic health. Chronic insomnia is associated with cardiometabolic diseases. Here, in two clinical cohorts (n = 7,931), authors show that gut microbiota-bile acid axis may be an intervention target to attenuate the impact of chronic insomnia on cardiometabolic health.

Automated summary

Evidence from human cohorts suggests that chronic insomnia is associated with a higher risk of cardiometabolic diseases. The gut microbiota-bile acid axis may play a role in this association. Certain gut microbial biomarkers and bile acids mediate the positive association between chronic insomnia and CMD, while habitual tea consumption has an opposite effect. Interventions targeting the microbiota-bile acid axis could potentially reduce the impact of chronic insomnia on cardiometabolic health.