Related references
Note: Only part of the references are listed.Targeted replacement of full-length CFTR in human airway stem cells by CRISPR-Cas9 for pan-mutation correction in the endogenous locus
Sriram Vaidyanathan et al.
MOLECULAR THERAPY (2022)
CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease
Emmanouela Tsagkaraki et al.
NATURE COMMUNICATIONS (2021)
Chromothripsis as an on-target consequence of CRISPR-Cas9 genome editing
Mitchell L. Leibowitz et al.
NATURE GENETICS (2021)
Gene replacement of α-globin with β-globin restores hemoglobin balance in β-thalassemia-derived hematopoietic stem and progenitor cells
M. Kyle Cromer et al.
NATURE MEDICINE (2021)
CRISPR-Cas9 globin editing can induce megabase-scale copy-neutral losses of heterozygosity in hematopoietic cells
J. Boutin et al.
NATURE COMMUNICATIONS (2021)
The mutational constraint spectrum quantified from variation in 141,456 humans
Konrad J. Karczewski et al.
NATURE (2020)
Gene-editing pipeline takes off
Asher Mullard
NATURE REVIEWS DRUG DISCOVERY (2020)
CHANGE-seq reveals genetic and epigenetic effects on CRISPR-Cas9 genome-wide activity
Cicera R. Lazzarotto et al.
NATURE BIOTECHNOLOGY (2020)
Cancer immunotherapy comes of age and looks for maturity
Amanda Finck et al.
NATURE COMMUNICATIONS (2020)
Highly efficient therapeutic gene editing of human hematopoietic stem cells
Yuxuan Wu et al.
NATURE MEDICINE (2019)
CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations
Gregoire Cullot et al.
NATURE COMMUNICATIONS (2019)
Human genome-edited hematopoietic stem cells phenotypically correct Mucopolysaccharidosis type I
Natalia Gomez-Ospina et al.
NATURE COMMUNICATIONS (2019)
Unbiased detection of CRISPR off-targets in vivo using DISCOVER-Seq
Beeke Wienert et al.
SCIENCE (2019)
Global Transcriptional Response to CRISPR/Cas9-AAV6-Based Genome Editing in CD34+ Hematopoietic Stem and Progenitor Cells
M. Kyle Cromer et al.
MOLECULAR THERAPY (2018)
p53 inhibits CRISPR-Cas9 engineering in human pluripotent stem cells
Robert J. Ihry et al.
NATURE MEDICINE (2018)
CRISPR-Cas9 genome editing induces a p53-mediated DNA damage response
Emma Haapaniemi et al.
NATURE MEDICINE (2018)
CRISPR/Cas9 genome editing in human hematopoietic stem cells
Rasmus O. Bak et al.
NATURE PROTOCOLS (2018)
Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting
Carsten T. Charlesworth et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2018)
A high-fidelity Cas9 mutant delivered as a ribonucleoprotein complex enables efficient gene editing in human hematopoietic stem and progenitor cells
Christopher A. Vakulskas et al.
NATURE MEDICINE (2018)
Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia
Stefanie Goellner et al.
NATURE MEDICINE (2017)
Deep intronic mutations and human disease
Rita Vaz-Drago et al.
HUMAN GENETICS (2017)
Mapping the genomic landscape of CRISPR-Cas9 cleavage
Peter Cameron et al.
NATURE METHODS (2017)
CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR Cas9 nuclease off-targets
Shengdar Q. Tsai et al.
NATURE METHODS (2017)
CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells
Daniel P. Dever et al.
NATURE (2016)
Targeting EZH2 in cancer
Kimberly H. Kim et al.
NATURE MEDICINE (2016)
The presence of extra chromosomes leads to genomic instability
Verena Passerini et al.
NATURE COMMUNICATIONS (2016)
A global reference for human genetic variation
David M. Altshuler et al.
NATURE (2015)
Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells
Ayal Hendel et al.
NATURE BIOTECHNOLOGY (2015)
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
Shengdar Q. Tsai et al.
NATURE BIOTECHNOLOGY (2015)
CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool
Manuel Stemmer et al.
PLOS ONE (2015)
Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
Sangsu Bae et al.
BIOINFORMATICS (2014)
Easy quantitative assessment of genome editing by sequence trace decomposition
Eva K. Brinkman et al.
NUCLEIC ACIDS RESEARCH (2014)
COSMID: A Web-based Tool for Identifying and Validating CRISPR/Cas Off-target Sites
Thomas J. Cradick et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2014)
EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
Wendy Beguelin et al.
CANCER CELL (2013)
The fractured genome of HeLa cells
David Mittelman et al.
GENOME BIOLOGY (2013)
Identification of Somatic Mutations in Parathyroid Tumors Using Whole-Exome Sequencing
M. Kyle Cromer et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2012)
EZH2 mutational status predicts poor survival in myelofibrosis
Paola Guglielmelli et al.
BLOOD (2011)
RUNX1 and its understudied role in breast cancer
Kevin A. Janes
CELL CYCLE (2011)
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
Ryan D. Morin et al.
NATURE GENETICS (2010)
Genetic diagnosis by whole exome capture and massively parallel DNA sequencing
Murim Choi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The tyrosine phosphatase Shp2 (PTPN11) in cancer
Gordon Chan et al.
CANCER AND METASTASIS REVIEWS (2008)
The role of Shp2 (PTPN11) in cancer
M. Golam Mohi et al.
CURRENT OPINION IN GENETICS & DEVELOPMENT (2007)