4.8 Article

Modulating co-translational protein folding by rational design and ribosome engineering

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Interactions between nascent proteins translated by adjacent ribosomes drive homomer assembly

Matilde Bertolini et al.

Summary: This study investigated whether newly synthesized proteins can form functional oligomers through co-co assembly. They found that this mechanism can lead to the co-assembly of hundreds of homomeric subunits in human cells, mainly mediated by N-terminal coiled coils among five major domain classes.

SCIENCE (2021)

Article Chemistry, Multidisciplinary

Interactions between nascent proteins and the ribosome surface inhibit co-translational folding

Anais M. E. Cassaignau et al.

Summary: The study characterizes interactions between the ribosome surface and unfolded nascent chains, with the strongest interactions found in the C-terminal segment essential for folding. Quantitative agreement is demonstrated between these interactions and the energetics of co-translational folding. Competition between folding and binding provides a simple, dynamic mechanism for the modulation of co-translational folding by the ribosome.

NATURE CHEMISTRY (2021)

Article Multidisciplinary Sciences

Common sequence motifs of nascent chains engage the ribosome surface and trigger factor

Annika Deckert et al.

Summary: The study reveals that interactions on the surface of ribosomes in cells determine the dynamics of emerging disordered polypeptides, with specific basic and aromatic motifs affecting these interactions and competing with trigger factors, while also guiding the direction of nascent chains. The ribosome acts as a scaffold with holdase characteristics, facilitating handover of nascent chains to specific auxiliary proteins in the cytosol.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Multidisciplinary Sciences

Mechanism of membrane-tethered mitochondrial protein synthesis

Yuzuru Itoh et al.

Summary: The study reveals the mechanism of interaction between human mitoribosomes and the insertase OXA1L, elucidating how membrane delivery is achieved during protein synthesis.

SCIENCE (2021)

Article Multidisciplinary Sciences

Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein

Elena Plessa et al.

Summary: Proteins can fold co-translationally during biosynthesis, with misfolding potentially causing disease. The alpha-1-antitrypsin protein folds under kinetic control, and misfolding may initiate from co-translational structures. Co-translational folding intermediates could drive how some proteins fold under kinetic control, serving as potential therapeutic targets for human disease.

NATURE COMMUNICATIONS (2021)

Article Chemistry, Multidisciplinary

Nascent chain dynamics and ribosome interactions within folded ribosome-nascent chain complexes observed by NMR spectroscopy

Charles Burridge et al.

Summary: This study used solution-state NMR spectroscopy to measure transverse proton relaxation rates for methyl groups in folded ribosome-nascent chain complexes, revealing interactions between the nascent chain and ribosome surface driven predominantly by electrostatics. By observing changes in these interactions as subsequent domain emerges, the impact on free energy landscapes associated with co-translational folding process can be deduced.

CHEMICAL SCIENCE (2021)

Review Biochemistry & Molecular Biology

How Does the Ribosome Fold the Proteome?

Anais M. E. Cassaignau et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89 (2020)

Article Biochemistry & Molecular Biology

The precious fluorine on the ring: fluorine NMR for biological systems

Andras Boeszoermenyi et al.

JOURNAL OF BIOMOLECULAR NMR (2020)

Article Multidisciplinary Sciences

Cysteine oxidation and disulfide formation in the ribosomal exit tunnel

Linda Schulte et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Differences in the path to exit the ribosome across the three domains of life

Khanh Dao Duc et al.

NUCLEIC ACIDS RESEARCH (2019)

Review Biochemistry & Molecular Biology

Nature and Regulation of Protein Folding on the Ribosome

Christopher A. Waudby et al.

TRENDS IN BIOCHEMICAL SCIENCES (2019)

Article Biology

SPHIRE-crYOLO is a fast and accurate fully automated particle picker for cryo-EM

Thorsten Wagner et al.

COMMUNICATIONS BIOLOGY (2019)

Article Biochemistry & Molecular Biology

CRISPOR: intuitive guide selection for CRISPR/Cas9 genome editing experiments and screens

Jean-Paul Concordet et al.

NUCLEIC ACIDS RESEARCH (2018)

Article Multidisciplinary Sciences

Facile bottom-up synthesis of partially oxidized black phosphorus nanosheets as metal-free photocatalyst for hydrogen evolution

Bin Tian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Biochemistry & Molecular Biology

How Messenger RNA and Nascent Chain Sequences Regulate Translation Elongation

Junhong Choi et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

Article Multidisciplinary Sciences

Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis

Christopher A. Waudby et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Biochemistry & Molecular Biology

Using Scipion for stream image processing at Cryo-EM facilities

J. Gomez-Blanco et al.

JOURNAL OF STRUCTURAL BIOLOGY (2018)

Article Plant Sciences

Structure of the chloroplast ribosome with chl-RRF and hibernation-promoting factor

Annemarie Perez Boerema et al.

NATURE PLANTS (2018)

Article Chemistry, Physical

POVME 3.0: Software for Mapping Binding Pocket Flexibility

Jeffrey R. Wagner et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2017)

Letter Biochemical Research Methods

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

Shawn Q. Zheng et al.

NATURE METHODS (2017)

Article Biochemical Research Methods

A strategy for co-translational folding studies of ribosome-bound nascent chain complexes using NMR spectroscopy

Anais M. E. Cassaignau et al.

NATURE PROTOCOLS (2016)

Article Biochemistry & Molecular Biology

A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding

Lisa D. Cabrita et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Multidisciplinary Sciences

Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors

Alexis I. Cocozaki et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

A structural ensemble of a ribosome-nascent chain complex during cotranslational protein folding

Lisa D. Cabrita et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)

Article Biochemical Research Methods

SMOG 2: A Versatile Software Package for Generating Structure-Based Models

Jeffrey K. Noel et al.

PLOS COMPUTATIONAL BIOLOGY (2016)

Article Biotechnology & Applied Microbiology

Multigene Editing in the Escherichia coli Genome via the CRISPR-Cas9 System

Yu Jiang et al.

APPLIED AND ENVIRONMENTAL MICROBIOLOGY (2015)

Article Chemistry, Physical

Efficient Sampling of High-Dimensional Free-Energy Landscapes with Parallel Bias Metadynamics

Jim Pfaendtner et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2015)

Article Biochemistry & Molecular Biology

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

Alexis Rohou et al.

JOURNAL OF STRUCTURAL BIOLOGY (2015)

Article Multidisciplinary Sciences

Protein synthesis by ribosomes with tethered subunits

Cedric Orelle et al.

NATURE (2015)

Article Multidisciplinary Sciences

History of the ribosome and the origin of translation

Anton S. Petrov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Cell Biology

Cotranslational Protein Folding inside the Ribosome Exit Tunnel

Ola B. Nilsson et al.

CELL REPORTS (2015)

Article Multidisciplinary Sciences

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

Alexey Amunts et al.

SCIENCE (2014)

Review Chemistry, Physical

Protein folding on the ribosome studied using NMR spectroscopy

Christopher A. Waudby et al.

PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (2013)

Article Chemistry, Multidisciplinary

Efficient determination of diffusion coefficients by monitoring transport during recovery delays in NMR

Rafal Augustyniak et al.

CHEMICAL COMMUNICATIONS (2012)

Article Chemistry, Physical

The Shadow Map: A General Contact Definition for Capturing the Dynamics of Biomolecular Folding and Function

Jeffrey K. Noel et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2012)

Article Chemistry, Multidisciplinary

Rapid Distinction of Intracellular and Extracellular Proteins Using NMR Diffusion Measurements

Christopher A. Waudby et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2012)

Article Biochemistry & Molecular Biology

A biphasic pulling force acts on transmembrane helices during translocon-mediated membrane integration

Nurzian Ismail et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)

Review Biophysics

Protein Folding at the Exit Tunnel

Daria V. Fedyukina et al.

ANNUAL REVIEW OF BIOPHYSICS, VOL 40 (2011)

Article Biochemistry & Molecular Biology

An Evolved Aminoacyl-tRNA Synthetase with Atypical Polysubstrate Specificity

Douglas D. Young et al.

BIOCHEMISTRY (2011)

Article Biochemistry & Molecular Biology

The ribosomal tunnel as a functional environment for nascent polypeptide folding and translational stalling

Daniel N. Wilson et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2011)

Article Chemistry, Multidisciplinary

Software News and Updates MDAnalysis: A Toolkit for the Analysis of Molecular Dynamics Simulations

Naveen Michaud-Agrawal et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2011)

Article Chemistry, Multidisciplinary

New Scenarios of Protein Folding Can Occur on the Ribosome

Edward P. O'Brien et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Biochemistry & Molecular Biology

Cryo-EM structure of the ribosome-SecYE complex in the membrane environment

Jens Frauenfeld et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2011)

Article Biochemistry & Molecular Biology

HMMER web server: interactive sequence similarity searching

Robert D. Finn et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Multidisciplinary Sciences

The Ribosome Modulates Nascent Protein Folding

Christian M. Kaiser et al.

SCIENCE (2011)

Article Biochemistry & Molecular Biology

SecM-Stalled Ribosomes Adopt an Altered Geometry at the Peptidyl Transferase Center

Shashi Bhushan et al.

PLOS BIOLOGY (2011)

Article Biochemical Research Methods

MolProbity: all-atom structure validation for macromolecular crystallography

Vincent B. Chen et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

Article Biochemical Research Methods

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Paul D. Adams et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

Review Biochemistry & Molecular Biology

Protein folding on the ribosome

Lisa D. Cabrita et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2010)

Software Review Chemistry, Multidisciplinary

Fityk: a general-purpose peak fitting program

Marcin Wojdyr

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2010)

Article Biochemistry & Molecular Biology

An Enhanced System for Unnatural Amino Acid Mutagenesis in E. coli

Travis S. Young et al.

JOURNAL OF MOLECULAR BIOLOGY (2010)

Article Biochemistry & Molecular Biology

α-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnel

Shashi Bhushan et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)

Article Biochemical Research Methods

Jalview Version 2-a multiple sequence alignment editor and analysis workbench

Andrew M. Waterhouse et al.

BIOINFORMATICS (2009)

Article Computer Science, Interdisciplinary Applications

PLUMED: A portable plugin for free-energy calculations with molecular dynamics

Massimiliano Bonomi et al.

COMPUTER PHYSICS COMMUNICATIONS (2009)

Article Biochemistry & Molecular Biology

Circos: An information aesthetic for comparative genomics

Martin Krzywinski et al.

GENOME RESEARCH (2009)

Review Biochemistry & Molecular Biology

Converging concepts of protein folding in vitro and in vivo

F. Ulrich Hartl et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)

Article Multidisciplinary Sciences

Probing ribosome-nascent chain complexes produced in vivo by NMR spectroscopy

Lisa D. Cabrita et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Chemistry, Physical

GROMACS 4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation

Berk Hess et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2008)

Article Biochemistry & Molecular Biology

Signal sequence-independent membrane targeting of ribosomes containing short nascent peptides within the exit tunnel

Thomas Bornemann et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2008)

Article Multidisciplinary Sciences

Revisiting the mechanism of macrolide-antibiotic resistance mediated by ribosomal protein L22

Sean D. Moore et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

Novel mutations in ribosomal proteins L4 and L22 that confer erythromycin resistance in Escherichia coli

Sephorah Zaman et al.

MOLECULAR MICROBIOLOGY (2007)

Article Multidisciplinary Sciences

Structure and dynamics of a ribosome-bound nascent chain by NMR spectroscopy

Shang-Te Danny Hsu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

Structure of the 70S ribosome complexed with mRNA and tRNA

Maria Selmer et al.

SCIENCE (2006)

Article Biochemical Research Methods

MultiSeq: unifying sequence and structure data for evolutionary analysis

Elijah Roberts et al.

BMC BIOINFORMATICS (2006)

Article Biochemistry & Molecular Biology

Translation arrest requires two-way communication between a nascent polypeptide and the ribosome

Cheryl A. Woolhead et al.

MOLECULAR CELL (2006)

Article Multidisciplinary Sciences

Structures of the bacterial ribosome at 3.5 Å resolution

BS Schuwirth et al.

SCIENCE (2005)

Article Biochemistry & Molecular Biology

Protein length in eukaryotic and prokaryotic proteomes

L Brocchieri et al.

NUCLEIC ACIDS RESEARCH (2005)

Article Biochemical Research Methods

Coot:: model-building tools for molecular graphics

P Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Review Multidisciplinary Sciences

Protein folding and misfolding

CM Dobson

NATURE (2003)

Article Biochemistry & Molecular Biology

Secretion monitor, SecM, undergoes self-translation arrest in the cytosol

H Nakatogawa et al.

MOLECULAR CELL (2001)

Article Multidisciplinary Sciences

The structural basis of ribosome activity in peptide bond synthesis

P Nissen et al.

SCIENCE (2000)