4.8 Article

Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster

Journal

NATURE COMMUNICATIONS
Volume 13, Issue 1, Pages -

Publisher

NATURE PORTFOLIO
DOI: 10.1038/s41467-022-30975-4

Keywords

-

Funding

  1. American Federation of Aging Research, NIH [R01AG038688, AG045835]
  2. Larry L. Hillblom Foundation [2019-A-02-FEL]
  3. NIH/NIA [AG000266]
  4. NIH [F31EY033179-01, R01-EY008117, R01-AI169386, R01-DC007864]
  5. Buck Institute Proteomics Core
  6. NCRR [1S10 OD016281]

Ask authors/readers for more resources

The research shows that dietary restriction extends the lifespan of fruit flies by promoting rhythmic homeostatic mechanisms in the visual system. Altering the core molecular clock transcription factor CLOCK or its output genes accelerates visual aging and shortens lifespan. Photoreceptor activation shortens lifespan, while inactivation extends it.
Many vital processes in the eye are under circadian regulation, and circadian dysfunction has emerged as a potential driver of eye aging. Dietary restriction is one of the most robust lifespan-extending therapies and amplifies circadian rhythms with age. Herein, we demonstrate that dietary restriction extends lifespan in Drosophila melanogaster by promoting circadian homeostatic processes that protect the visual system from age- and light-associated damage. Altering the positive limb core molecular clock transcription factor, CLOCK, or CLOCK-output genes, accelerates visual senescence, induces a systemic immune response, and shortens lifespan. Flies subjected to dietary restriction are protected from the lifespan-shortening effects of photoreceptor activation. Inversely, photoreceptor inactivation, achieved via mutating rhodopsin or housing flies in constant darkness, primarily extends the lifespan of flies reared on a high-nutrient diet. Our findings establish the eye as a diet-sensitive modulator of lifespan and indicates that vision is an antagonistically pleiotropic process that contributes to organismal aging. Circadian dysfunction is a potential driver of eye aging. Here the authors report that in conjunction with the core molecular clock transcription factor Clock, dietary restriction promotes rhythmic homeostatic mechanisms within photoreceptors to delay visual senescence and extend lifespan in Drosophila Melanogaster.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available