4.8 Article

Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277

Related references

Note: Only part of the references are listed.
Article Neurosciences

Structural insights into the lipid and ligand regulation of a human neuronal KCNQ channel

You Zheng et al.

Summary: This study reports the cryo-EM structures of human KCNQ4 and uncovers the molecular mechanism of phosphatidylinositol 4,5-bisphosphate (PIP2) in modulating the opening of this channel.

NEURON (2022)

Article Biology

Molecular dynamics simulations suggest possible activation and deactivation pathways in the hERG channel

Flavio Costa et al.

Summary: This study investigated the activation/deactivation mechanism of hERG, a voltage-gated potassium channel involved in severe inherited and drug-induced cardiac channelopathies, including Long QT Syndrome. The results revealed two distinct pathways connecting the voltage sensor domain with the pore domain, and identified LQTS-related mutations distributed along these pathways, providing a microscopic interpretation of their role. Additionally, it was found that the channel still functions as a gate even when a cut is introduced between the voltage sensor domain and the neighboring helix S5.

COMMUNICATIONS BIOLOGY (2022)

Article Cell Biology

Molecular basis for ligand activation of the human KCNQ2 channel

Xiaoxiao Li et al.

Summary: Cryo-EM structures of human KCNQ2 in apo state and in complex with two activators, zzt240 or retigabine, reveal different ligand recognition and activation mechanisms, providing a structural basis for drug optimization and design.

CELL RESEARCH (2021)

Article Biochemistry & Molecular Biology

UCSF ChimeraX: Structure visualization for researchers, educators, and developers

Eric F. Pettersen et al.

Summary: UCSF ChimeraX is a powerful visualization program with enhanced performance and graphics, offering new tools and analysis features, support for various areas like virtual reality, and improved ease of use, along with an app store for researchers to contribute new tools.

PROTEIN SCIENCE (2021)

Article Biochemistry & Molecular Biology

Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs

Tian Li et al.

Summary: This study presents the cryoEM structures of human KCNQ4 and its complexes with different drugs, revealing a unique binding mode of phosphatidylinositol 4,5-bisphosphate (PIP2) in each voltage-sensing domain (VSD) cavity. The findings provide insights into the regulatory mechanism of neuronal KCNQ channels and offer a framework for structure-assisted drug discovery targeting these important channels.

MOLECULAR CELL (2021)

Article Physiology

ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state

Jodene Eldstrom et al.

Summary: ML277, an activator of KCNQ1 channels, enhances KCNQ1 single-channel kinetics by converting the flickering nature of openings to discrete bursts and increasing amplitudes. The drug's effects on KCNQ1 behavior resemble IO state-locked channels, suggesting that KCNQ1 may not frequently visit the AO state during ML277 treatment. The pore effects of the drug are shown to be equally important as its whole-cell gating actions.

JOURNAL OF GENERAL PHYSIOLOGY (2021)

Article Biochemistry & Molecular Biology

Structural Basis of Human KCNQ1 Modulation and Gating

Ji Sun et al.

Article Multidisciplinary Sciences

Two-stage electro-mechanical coupling of a KV channel in voltage-dependent activation

Panpan Hou et al.

NATURE COMMUNICATIONS (2020)

Article Chemistry, Physical

PSI4 1.4: Open-source software for high-throughput quantum chemistry

Daniel G. A. Smith et al.

JOURNAL OF CHEMICAL PHYSICS (2020)

Review Physiology

Gating and Regulation of KCNQ1 and KCNQ1+KCNE1 Channel Complexes

Yundi Wang et al.

FRONTIERS IN PHYSIOLOGY (2020)

Article Biochemical Research Methods

Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction

Ali Punjani et al.

NATURE METHODS (2020)

Article Multidisciplinary Sciences

Upgraded molecular models of the human KCNQ1 potassium channel

Georg Kuenze et al.

PLOS ONE (2019)

Article Biochemical Research Methods

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

Dorothee Liebschner et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2019)

Article Neurosciences

Action potential shortening rescues atrial calcium alternans

Giedrius Kanaporis et al.

JOURNAL OF PHYSIOLOGY-LONDON (2019)

Article Biology

SPHIRE-crYOLO is a fast and accurate fully automated particle picker for cryo-EM

Thorsten Wagner et al.

COMMUNICATIONS BIOLOGY (2019)

Article Biochemistry & Molecular Biology

Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K+ channel

Ana I. Fernandez-Marino et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Gating interaction maps reveal a noncanonical electromechanical coupling mode in the Shaker K+ channel

Ana I. Fernandez-Marino et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)

Article Biochemical Research Methods

CHARMM36m: an improved force field for folded and intrinsically disordered proteins

Jing Huang et al.

NATURE METHODS (2017)

Article Biochemical Research Methods

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

Ali Punjani et al.

NATURE METHODS (2017)

Article Cardiac & Cardiovascular Systems

Predicting the Functional Impact of KCNQ1 Variants of Unknown Significance

Bian Li et al.

CIRCULATION-CARDIOVASCULAR GENETICS (2017)

Review Neurosciences

The KCNQ1 channel - remarkable flexibility in gating allows for functional versatility

Sara I. Liin et al.

JOURNAL OF PHYSIOLOGY-LONDON (2015)

Article Biochemistry & Molecular Biology

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

Alexis Rohou et al.

JOURNAL OF STRUCTURAL BIOLOGY (2015)

Article Cardiac & Cardiovascular Systems

LQT1 mutations in KCNQ1 C-terminus assembly domain suppress IKs using different mechanisms

Ademuyiwa S. Aromolaran et al.

CARDIOVASCULAR RESEARCH (2014)

Article Multidisciplinary Sciences

Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening

Mark A. Zaydman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Single-channel basis for the slow activation of the repolarizing cardiac potassium current, IKs

Daniel Werry et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels

Haibo Yu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Intracellular ATP binding is required to activate the slowly activating K+ channel IKs

Yang Li et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Structural Requirements of Membrane Phospholipids for M-type Potassium Channel Activation and Binding

Vsevolod Telezhkin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Chemistry, Medicinal

Automation of the CHARMM General Force Field (CGenFF) II: Assignment of Bonded Parameters and Partial Atomic Charges

K. Vanommeslaeghe et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)

Article Chemistry, Medicinal

Automation of the CHARMM General Force Field (CGenFF) I: Bond Perception and Atom Typing

K. Vanommeslaeghe et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2012)

Article Chemistry, Physical

MMPBSA.py: An Efficient Program for End-State Free Energy Calculations

Bill R. Miller et al.

JOURNAL OF CHEMICAL THEORY AND COMPUTATION (2012)

Article Biophysics

Allosteric Features of KCNQ1 Gating Revealed by Alanine Scanning Mutagenesis

Li-Juan Ma et al.

BIOPHYSICAL JOURNAL (2011)

Article Biochemistry & Molecular Biology

The S4-S5 Linker of KCNQ1 Channels Forms a Structural Scaffold with the S6 Segment Controlling Gate Closure

Alain J. Labro et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Chemistry, Physical

Development of the CHARMM Force Field for Lipids

R. W. Pastor et al.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2011)

Article Biochemical Research Methods

MolProbity: all-atom structure validation for macromolecular crystallography

Vincent B. Chen et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

Article Biochemical Research Methods

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Paul D. Adams et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2010)

Article Multidisciplinary Sciences

Stoichiometry of the KCNQ1-KCNE1 ion channel complex

Koichi Nakajo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Cardiac & Cardiovascular Systems

Biophysical Properties of 9 KCNQ1 Mutations Associated With Long-QT Syndrome

Tao Yang et al.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2009)

Article Multidisciplinary Sciences

Discovery of a Novel Activator of KCNQ1-KCNE1 K+ Channel Complexes

Karen Mruk et al.

PLOS ONE (2009)

Article Cell Biology

Arrhythmia in Heart and Brain: KCNQ1 Mutations Link Epilepsy and Sudden Unexplained Death

A. M. Goldman et al.

SCIENCE TRANSLATIONAL MEDICINE (2009)

Article Chemistry, Multidisciplinary

Software news and updates - CHARNIM-GUI: A web-based grraphical user interface for CHARMM

Sunhwan Jo et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2008)

Article Neurosciences

The C-terminus of Kv7 channels: a multifunctional module

Yoni Haitin et al.

JOURNAL OF PHYSIOLOGY-LONDON (2008)

Review Pharmacology & Pharmacy

Activation of Kv7 (KCNQ) voltage-gated potassium channels by synthetic compounds

Qiaojie Xiong et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2008)

Article Biochemistry & Molecular Biology

A derivatized scorpion toxin reveals the functional output of heteromeric KCNQ1-KCNE K+ channel complexes

Trevor J. Morin et al.

ACS CHEMICAL BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants

Qiaojie Xiong et al.

NATURE CHEMICAL BIOLOGY (2007)

Article Chemistry, Physical

Canonical sampling through velocity rescaling

Giovanni Bussi et al.

JOURNAL OF CHEMICAL PHYSICS (2007)

Article Cardiac & Cardiovascular Systems

Calmodulin is essential for cardiac IKS channel gating and assembly -: Impaired function in long-QT mutations

L Shamgar et al.

CIRCULATION RESEARCH (2006)

Article Pharmacology & Pharmacy

L-364,373 fails to activate the slow delayed rectifier K+ current in canine ventricular cardiomyocytes

J Magyar et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2006)

Article Cardiac & Cardiovascular Systems

In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heart

S Bendahhou et al.

CARDIOVASCULAR RESEARCH (2005)

Article Biochemical Research Methods

Coot:: model-building tools for molecular graphics

P Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Dual phosphorylations underlie modulation of unitary KCNQ K+ channels by Src tyrosine kinase

Y Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)

Article Neurosciences

Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels

G Seebohm et al.

JOURNAL OF PHYSIOLOGY-LONDON (2003)

Article Neurosciences

Properties of single M-type KCNQ2/KCNQ3 potassium channels expressed in mammalian cells

AA Selyanko et al.

JOURNAL OF PHYSIOLOGY-LONDON (2001)

Article Biochemistry & Molecular Biology

Identification of specific pore residues mediating KCNQ1 inactivation - A novel mechanism for long QT syndrome

G Seebohm et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)

Article Multidisciplinary Sciences

A constitutively open potassium channel formed by KCNQ1 and KCNE3

BC Schroeder et al.

NATURE (2000)