4.8 Article

Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis

Related references

Note: Only part of the references are listed.
Article Pathology

Collagen XII Regulates Corneal Stromal Structure by Modulating Transforming Growth Factor-β Activity

Mei Sun et al.

Summary: Collagen XII plays a crucial role in regulating the activity and latency of TGF-beta in the corneal stroma. Its absence leads to hypertrophic corneal tissue with abnormal up-regulation of TGF-beta activation and decreased latent storage. Collagen XII regulates the synthesis and deposition of collagens in the extracellular matrix, and it controls the balance between active and latent TGF-beta.

AMERICAN JOURNAL OF PATHOLOGY (2022)

Article Biochemistry & Molecular Biology

Collagen XII mediated cellular and extracellular mechanisms regulate establishment of tendon structure and function

Yayoi Izu et al.

Summary: Collagen XII plays dual roles in tendon development by influencing fibril packing, fiber assembly and stability, as well as regulating tenocyte organization and intercellular communication. Its deficiency results in altered cell shape, impaired cell-cell communication, and decreased tissue stiffness, indicating its crucial role in tendon structure and function. Additionally, collagen XII specifically affects tenocyte biosynthesis and provides feedback to regulate extracellular collagen I, highlighting its significance in tendon development and maintenance.

MATRIX BIOLOGY (2021)

Article Chemistry, Physical

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

Ori Maller et al.

Summary: Stromal stiffening in malignant tumours is associated with poor treatment outcomes and increased tumour aggression. Identifying factors that regulate stromal stiffening could lead to biomarkers for patient stratification and interventions to improve outcomes. Experimental studies have shown that therapeutic targeting of tumour-associated macrophages and collagen crosslinking enzymes can reduce metastasis and stromal stiffening in aggressive breast cancer subtypes with stiff stroma. Additionally, the expression of lysyl hydroxylase 2 in the stroma has been linked to disease-specific mortality in breast cancer patients, indicating its potential as a stromal biomarker.

NATURE MATERIALS (2021)

Review Biochemistry & Molecular Biology

Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo

Sherif Attalla et al.

Summary: Understanding breast cancer progression, metastasis, and therapeutic discovery is crucial. The MMTV-PyMT mouse model is a valuable tool that helps researchers better understand the molecular basis of breast cancer.

ONCOGENE (2021)

Article Oncology

Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer

Yang Chen et al.

Summary: The stromal desmoplastic reaction in pancreatic ductal adenocarcinoma involves significant accumulation of type I collagen (Col1). Deletion of Col1 specifically in myofibroblasts accelerates PDAC progression by increasing Cxcl5 expression in cancer cells and promoting recruitment of myeloid-derived suppressor cells. Targeting CXCR2 and CCR2 may help restrain accelerated PDAC progression in the absence of stromal Col1.

CANCER CELL (2021)

Article Multidisciplinary Sciences

Tumour DDR1 promotes collagen fibre alignment to instigate immune exclusion

Xiujie Sun et al.

Summary: The study identifies a new mechanism of immune exclusion mediated by DDR1-ECD through promoting collagen fiber alignment. Inhibition of DDR1 promotes intratumoral penetration of T cells and eradicates tumor growth in TNBC.

NATURE (2021)

Article Multidisciplinary Sciences

Intravital imaging technology guides FAK-mediated priming in pancreatic cancer precision medicine according to Merlin status

Kendelle J. Murphy et al.

Summary: In this study, transient manipulation of focal adhesion kinase in PDAC was visualized using intravital fluorescence imaging, with real-time quantification of cell cycle reporter to improve chemotherapy response. Analysis of different matrices and environmental cues helped to reduce PDAC metastasis.

SCIENCE ADVANCES (2021)

Article Immunology

Matrix compliance permits NF-κB activation to drive therapy resistance in breast cancer

Allison P. Drain et al.

Summary: Triple-negative breast cancers are associated with poor survival due to treatment resistance. The stiffness of the extracellular matrix (ECM) affects treatment response, with soft ECM promoting treatment resistance and stiff ECM sensitizing cells to treatment. Agents that modulate stiffness-dependent NF-kappa B or JNK activity could enhance therapeutic efficacy in patients with TNBC.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Multidisciplinary Sciences

Suppression of pancreatic ductal adenocarcinoma growth and metastasis by fibrillar collagens produced selectively by tumor cells

Chenxi Tian et al.

Summary: The ECM of pancreatic ductal adenocarcinoma has partially uncleaved C-terminal prodomains of fibrillar collagens, indicating reduced procollagen C-proteinase activity. The enzyme BMP1 selectively suppresses tumor growth and metastasis in cells expressing high levels of COL1A1. Cancer-cell-derived fibrillar collagen plays a role in selectively restraining tumor growth.

NATURE COMMUNICATIONS (2021)

Article Cell Biology

Single-cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype

Fatima Valdes-Mora et al.

Summary: The study used unbiased droplet-based single-cell RNA sequencing to elucidate the cellular basis of tumor progression in basal breast cancer, finding that basal-like cancer cells mimic a post-lactation developmental program, leading to remodeling of the tumor microenvironment and metastatic dissemination. This involution mimicry involves a highly interactive multicellular network, with cancer-associated fibroblasts playing a key role in extracellular matrix remodeling and immunosuppression.

CELL REPORTS (2021)

Article Cell Biology

CCM3 is a gatekeeper in focal adhesions regulating mechanotransduction and YAP/TAZ signalling

Shan Wang et al.

Summary: Wang et al. have identified CCM3 as a negative regulator of YAP/TAZ activation and mechanotransduction in focal adhesions, with crucial roles in controlling mesenchymal/stromal stem cell differentiation and metastasis. CCM3 functions as a gatekeeper in focal adhesions, regulating mechanotransduction and YAP/TAZ signaling by competing with focal adhesion kinase for binding to paxillin. Loss of CCM3 in cancer-associated fibroblasts leads to exacerbated tissue remodelling and metastasis dissemination in mouse models of breast cancer.

NATURE CELL BIOLOGY (2021)

Article Cell Biology

Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging

Alessia Floerchinger et al.

Summary: Assessing drug response within live native tissue provides increased fidelity in optimizing efficacy and minimizing off-target effects. Using single-cell intravital imaging, this study demonstrates that Rac1 inhibition can reduce tumor progression and metastases to improve overall survival in an autochthonous setting. The study also reveals enhanced Rac1 activity of cells near live tumor vasculature, and how Rac1 inhibition can enhance tumor cell vulnerability to fluid-flow-induced shear stress for better anti-metastatic response during transit to secondary sites.

CELL REPORTS (2021)

Article Biology

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

Alba Nicolas-Boluda et al.

Summary: The study found that tumor stiffness is strongly correlated with tumor growth and ECM crosslinking, but negatively correlated with T cell migration. Interfering with collagen stabilization can reduce ECM content and tumor stiffness, improving T cell migration and the efficacy of anti-PD-1 blockade.

ELIFE (2021)

Review Oncology

The matrix in cancer

Thomas R. Cox

Summary: Alterations in the extracellular matrix play a crucial role in the development and progression of solid tumours, and our understanding of matrix biology is expanding. New approaches targeting the matrix in cancer are being developed.

NATURE REVIEWS CANCER (2021)

Article Immunology

Matrix compliance permits NF-kappa B activation to drive therapy resistance in breast cancer

Allison P. Drain et al.

Summary: Soft extracellular matrix protects breast cancer cells from apoptosis, reduces the efficacy of chemo- and radiation therapies, and enhances NF-kappa B signaling while diminishing proapoptotic JNK activity. Therapeutic targeting of the NF-kappa B-JNK axis may help overcome treatment resistance in breast cancer, particularly in triple-negative breast cancers (TNBCs). Residual TNBCs residing in a softer stromal microenvironment exhibit elevated NF-kappa B activity and compromised JNK activity, contributing to treatment resistance.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Editorial Material Biochemistry & Molecular Biology

SnapShot: Cancer-Associated Fibroblasts

Danielle Park et al.

Article Medicine, Research & Experimental

Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217

Jason J. Northey et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Biochemistry & Molecular Biology

Role of collagen XII in skin homeostasis and repair

Katrin Schonboern et al.

MATRIX BIOLOGY (2020)

Article Multidisciplinary Sciences

Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion

David H. Peng et al.

NATURE COMMUNICATIONS (2020)

Article Oncology

A framework for advancing our understanding of cancer-associated fibroblasts

Erik Sahai et al.

NATURE REVIEWS CANCER (2020)

Review Cell Biology

The Extracellular Matrix Modulates the Metastatic Journey

FuiBoon Kai et al.

DEVELOPMENTAL CELL (2019)

Article Multidisciplinary Sciences

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells

Chenxi Tian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemical Research Methods

Single-pot, solid-phase-enhanced sample preparation for proteomics experiments

Christopher S. Hughes et al.

NATURE PROTOCOLS (2019)

Review Oncology

CAF Subpopulations: A New Reservoir of Stromal Targets in Pancreatic Cancer

Brooke A. Pereira et al.

TRENDS IN CANCER (2019)

Article Biochemistry & Molecular Biology

Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate

Zhongmin Liu et al.

Article Biotechnology & Applied Microbiology

Integrating single-cell transcriptomic data across different conditions, technologies, and species

Andrew Butler et al.

NATURE BIOTECHNOLOGY (2018)

Article Oncology

Collagen Alignment as a Predictor of Recurrence after Ductal Carcinoma In Situ

Matthew W. Conklin et al.

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION (2018)

Article Biochemical Research Methods

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics

Alexandra Naba et al.

JOURNAL OF PROTEOME RESEARCH (2017)

Article Biochemistry & Molecular Biology

ISDoT: in situ decellularization of tissues for high-resolution imaging and proteomic analysis of native extracellular matrix

Alejandro E. Mayorca-Guiliani et al.

NATURE MEDICINE (2017)

Article Multidisciplinary Sciences

Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival

Vasilena Gocheva et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Three-dimensional organotypic matrices from alternative collagen sources as pre-clinical models for cell biology

James R. W. Conway et al.

SCIENTIFIC REPORTS (2017)

Article Engineering, Biomedical

Comprehensive proteomic characterization of stem cell -derived extracellular matrices

Heloise Ragelle et al.

BIOMATERIALS (2017)

Article Cell Biology

Stromal dynamic reciprocity in cancer: intricacies of fibroblastic-ECM interactions

Jennifer Alexander et al.

CURRENT OPINION IN CELL BIOLOGY (2016)

Review Oncology

Raised mammographic density: causative mechanisms and biological consequences

Michael J. Sherratt et al.

BREAST CANCER RESEARCH (2016)

Article Biochemistry & Molecular Biology

limma powers differential expression analyses for RNA-sequencing and microarray studies

Matthew E. Ritchie et al.

NUCLEIC ACIDS RESEARCH (2015)

Article Biochemistry & Molecular Biology

Mutations in the collagen XII gene define a new form of extracellular matrix-related myopathy

Debbie Hicks et al.

HUMAN MOLECULAR GENETICS (2014)

Article Biochemistry & Molecular Biology

Collagen XII: Protecting bone and muscle integrity by organizing collagen fibrils

Matthias Chiquet et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2014)

Article Cell Biology

Picrosirius Red Staining: A Useful Tool to Appraise Collagen Networks in Normal and Pathological Tissues

Raed Lattouf et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2014)

Review Cell Biology

Extracellular matrix assembly: a multiscale deconstruction

Janna K. Mouw et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Article Biochemical Research Methods

The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices

Alexandra Naba et al.

MOLECULAR & CELLULAR PROTEOMICS (2012)

Article Multidisciplinary Sciences

Comprehensive molecular portraits of human breast tumours

Daniel C. Koboldt et al.

NATURE (2012)

Article Biochemical Research Methods

NIH Image to ImageJ: 25 years of image analysis

Caroline A. Schneider et al.

NATURE METHODS (2012)

Article Biochemical Research Methods

Second harmonic generation microscopy for quantitative analysis of collagen fibrillar structure

Xiyi Chen et al.

NATURE PROTOCOLS (2012)

Article Biochemistry & Molecular Biology

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

Davis J. McCarthy et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Pathology

Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma

Matthew W. Conklin et al.

AMERICAN JOURNAL OF PATHOLOGY (2011)

Article Multidisciplinary Sciences

Organotypic Collagen I Assay: A Malleable Platform to Assess Cell Behaviour in a 3-Dimensional Context

Paul Timpson et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2011)

Article Biochemical Research Methods

Scoring of collagen organization in healthy and diseased human dermis by multiphoton microscopy

Riccardo Cicchi et al.

JOURNAL OF BIOPHOTONICS (2010)

Article Biochemistry & Molecular Biology

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Kandice R. Levental et al.

Article Pathology

An antimetastatic role for decorin in breast cancer

Silvia Goldoni et al.

AMERICAN JOURNAL OF PATHOLOGY (2008)

Article Medicine, General & Internal

Collagen density promotes mammary tumor initiation and progression

Paolo P. Provenzano et al.

BMC MEDICINE (2008)

Article Cell Biology

Myofibroblast contraction activates latent TGF-β1 from the extracellular matrix

Pierre-Jean Wipff et al.

JOURNAL OF CELL BIOLOGY (2007)

Article Medicine, General & Internal

Mammographic density and the risk and detection of breast cancer

Norman F. Boyd et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Medicine, General & Internal

Collagen reorganization at the tumor-stromal interface facilitates local invasion

Paolo P. Provenzano et al.

BMC MEDICINE (2006)

Article Biochemistry & Molecular Biology

Collagen XII interacts with Avian tenascin-X through its NC3 domain

Guido Veit et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Biochemistry & Molecular Biology

Decorin prevents metastatic spreading of breast cancer

CC Reed et al.

ONCOGENE (2005)

Article Biophysics

Interpreting second-harmonic generation images of collagen I fibrils

RM Williams et al.

BIOPHYSICAL JOURNAL (2005)

Article Oncology

Modulation of collagen fibrillogenesis by tenascin-X and type VI collagen

T Minamitani et al.

EXPERIMENTAL CELL RESEARCH (2004)

Article Medicine, General & Internal

Heritability of mammographic density, a risk factor for breast cancer

NF Boyd et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

Article Biochemistry & Molecular Biology

The roles of types XII and XIV collagen in fibrillogenesis and matrix assembly in the developing cornea

BB Young et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2002)

Article Multidisciplinary Sciences

Taking cell-matrix adhesions to the third dimension

E Cukierman et al.

SCIENCE (2001)