1,2-Amino oxygenation of alkenes with hydrogen evolution reaction

1,2-Amino oxygenation of alkenes has emerged as one of the most straightforward synthetic methods to produce beta-amino alcohols, which are important organic building blocks. Thus, a practical synthetic strategy for 1,2-amino oxygenation is highly desirable. Here, we reported an electro-oxidative intermolecular 1,2-amino oxygenation of alkenes with hydrogen evolution, removing the requirement of extra-oxidant. Using commercial oxygen and nitrogen sources as starting materials, this method provides a cheap, scalable, and efficient route to a set of valuable beta-amino alcohol derivatives. Moreover, the merit of this protocol has been exhibited by its broad substrate scope and good application in continuous-flow reactors. Furthermore, this method can be extended to other amino-functionalization of alkenes, thereby showing the potential to inspire advances in applications of electro-induced N-centered radicals (NCRs). 1,2-Aminoxygenation of alkenes without extra oxidant is a practical yet challenging way to prepare beta-amino alcohols. Here, the authors report an electro-oxidative route achieving such a goal with H2 evolution, exhibiting broad scope and application potential.

Automated summary

This article reports an electro-oxidative method for the 1,2-amino oxygenation of alkenes without the need for additional oxidants. This method offers a cheap, scalable, and efficient route for the synthesis of valuable beta-amino alcohol derivatives. The method also shows broad substrate scope and potential for application in continuous-flow reactors, as well as the possibility for further amino-functionalization reactions of alkenes.