The Netherlands Heart Tissue Bank Strengthening the cardiovascular research infrastructure with an open access Cardiac Tissue Repository

Review Biochemistry & Molecular Biology

The Human Explanted Heart Program: A translational bridge for cardiovascular medicine

Hao Zhang et al.

Summary: The lack of reliable disease models that fully recapitulate the pathogenesis in humans hinders the progression of cardiovascular research. The Human Explanted Heart Program (HELP) integrates clinical, tissue and molecular phenotyping to provide a comprehensive evaluation into human heart disease. The use of human heart tissue specimens has proven invaluable in genetic, molecular, cellular, and histological studies, providing novel insights into heart failure.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Theresa A. McDonagh et al.

EUROPEAN HEART JOURNAL (2021)

Add to Collection

Review Cardiac & Cardiovascular Systems

Towards precision medicine in heart failure

Chad S. Weldy et al.

Summary: This review summarizes the biology of heart failure, highlighting the importance of genetic predisposition in individual patient for precision therapy. It discusses the causal relationships between genetic contributors and traditional structure-based remodelling outcomes, as well as the mechanisms of action of both traditional and novel therapeutics.

NATURE REVIEWS CARDIOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences