4.7 Review

Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration

Related references

Note: Only part of the references are listed.
Article Endocrinology & Metabolism

Galectin-3 protects against ischemic stroke by promoting neuro-angiogenesis via apoptosis inhibition and Akt/Caspase regulation

Umadevi Wesley et al.

Summary: The study demonstrates the neuroprotective role of Gal3 in ischemic stroke by modulating angiogenic and apoptotic pathways, leading to improved functional recovery in rat brains.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

Article Clinical Neurology

Evaluation of serum galectin-3 levels at Alzheimer patients by stages: a preliminary report

Tamer Yazar et al.

Summary: This study found that serum galectin-3 levels were significantly higher in patients with Alzheimer's disease compared to healthy controls, while other parameters showed no significant differences between the groups. Additionally, it was observed that serum galectin-3 levels, patient age, and disease duration all significantly increased with the stage of the disease in all Alzheimer's disease patients.

ACTA NEUROLOGICA BELGICA (2021)

Article Immunology

Extracellular cardiolipin modulates microglial phagocytosis and cytokine secretion in a toll-like receptor (TLR) 4-dependent manner

Tyler J. Wenzel et al.

Summary: The study found that extracellular cardiolipin can affect the secretion and phagocytosis of microglia, with Toll-like receptor 4 mediating the latter effect. Under conditions of cell death, extracellularly released cardiolipin may regulate the immune responses of microglia.

JOURNAL OF NEUROIMMUNOLOGY (2021)

Article Medicine, Research & Experimental

Melatonin Decreases Circulating Levels of Galectin-3 and Cytokines, Motor Activity, and Anxiety Following Acute Global Cerebral Ischemia in Male Rats

Bertha Fenton-Navarro et al.

Summary: This study investigated the changes in circulating Galectin-3 (Gal-3) and cytokines (TNF-alpha, IL-6, IL-10) following global cerebral ischemia (GCI) in a rat model, as well as the effects of melatonin treatment. The results showed that melatonin treatment reduced pro-inflammatory factors, Gal-3 levels, locomotion, and anxiety, suggesting its potential as a supplementary treatment for ischemic stroke.

ARCHIVES OF MEDICAL RESEARCH (2021)

Article Neurosciences

White matter aging drives microglial diversity

Shima Safaiyan et al.

Summary: Research has identified white matter-associated microglia (WAMs) as a protective response during aging, characterized by phagocytic activity and lipid metabolism gene activation. WAMs depend on triggering receptor expressed on myeloid cells 2 (TREM2) signaling and are independent of apolipoprotein E (APOE) in contrast to mouse models of Alzheimer's disease.

NEURON (2021)

Article Immunology

Microglia use TAM receptors to detect and engulf amyloid β plaques

Youtong Huang et al.

Summary: The TAM receptor kinases are found to be essential for microglial recognition and engulfment of amyloid plaques in Alzheimer's disease, with their phagocytosis actually promoting the formation of dense-core plaques. This study also reveals that Axl and Mer play crucial roles in microglial response to amyloid plaques, and their deficiency leads to impaired detection, response, organization, and phagocytosis of amyloid-beta plaques.

NATURE IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

Alexandra Grubman et al.

Summary: The study reveals that microglia associated with A beta plaques may have a distinct transcriptional signature compared to those in plaque-free areas of the brain in Alzheimer's disease (AD) models. This suggests that amyloid plaque phagocytosis is associated with a specific microglia transcriptional signature in a mouse model of AD.

NATURE COMMUNICATIONS (2021)

Article Clinical Neurology

Time-dependent, dynamic prediction of fatty acid-binding protein 4, Galectin-3, and soluble ST2 measurement with poor outcome after acute stroke

Christina Hansen et al.

Summary: Elevated levels of FABP4, Galectin-3, and soluble ST2 were associated with poor outcomes and mortality in acute stroke patients. Galectin-3 performed better at admission, while soluble ST2 was more predictive 48 hours after the stroke, suggesting a time-dependent difference in the role of these pathways post-stroke.

INTERNATIONAL JOURNAL OF STROKE (2021)

Review Biochemistry & Molecular Biology

The emerging role of galectins in (re)myelination and its potential for developing new approaches to treat multiple sclerosis

Charlotte G. H. M. de Jong et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

Article Cell Biology

Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal

Jingyue Jia et al.

DEVELOPMENTAL CELL (2020)

Article Multidisciplinary Sciences

Microglia clear neuron-released a-synuclein via selective autophagy and prevent neurodegeneration

Insup Choi et al.

NATURE COMMUNICATIONS (2020)

Article Endocrinology & Metabolism

Prevalence of mild cognitive impairment in type 2 diabetes mellitus is associated with serum galectin-3 level

Shizhan Ma et al.

JOURNAL OF DIABETES INVESTIGATION (2020)

Review Clinical Neurology

Galectins in the brain: advances in neuroinflammation, neuroprotection and therapeutic opportunities

Francisca Barake et al.

CURRENT OPINION IN NEUROLOGY (2020)

Article Biochemistry & Molecular Biology

LRRK2 activation controls the repair of damaged endomembranes in macrophages

Susanne Herbst et al.

EMBO JOURNAL (2020)

Review Cell Biology

Microglia: Agents of the CNS Pro-Inflammatory Response

Jose A. Rodriguez-Gomez et al.

CELLS (2020)

Article Multidisciplinary Sciences

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency

Jiasheng Zhang et al.

NATURE (2020)

Review Clinical Neurology

The microglial component of amyotrophic lateral sclerosis

Benjamin E. Clarke et al.

BRAIN (2020)

Proceedings Paper Clinical Neurology

The Role of Galectin-3 in Subarachnoid Hemorrhage: A Preliminary Study

Hirofumi Nishikawa et al.

SUBARACHNOID HEMORRHAGE: NEUROLOGICAL CARE AND PROTECTION (2020)

Article Neurosciences

Delayed Galectin-3-Mediated Reprogramming of Microglia After Stroke is Protective

Reza Rahimian et al.

MOLECULAR NEUROBIOLOGY (2019)

Article Neurosciences

Dysregulation of TLR5 and TAM Ligands in the Alzheimer's Brain as Contributors to Disease Progression

Marisol Herrera-Rivero et al.

MOLECULAR NEUROBIOLOGY (2019)

Article Clinical Neurology

The roles of galectin-3 and galectin-4 in the idiopatic Parkinson disease and its progression

Tugba Cengiz et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2019)

Article Neurosciences

Co-Effect of Serum Galectin-3 and High-Density Lipoprotein Cholesterol on the Prognosis of Acute Ischemic Stroke

Nimei Zeng et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2019)

Article Neurosciences

Differential Cellular Expression of Galectin-1 and Galectin-3 After Intracerebral Hemorrhage

Frederick Bonsack et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

Review Immunology

Toll-like receptors in the pathogenesis of neuroinflammation

V Kumar

JOURNAL OF NEUROIMMUNOLOGY (2019)

Article Neurosciences

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes

Sarah H. Shahmoradian et al.

NATURE NEUROSCIENCE (2019)

Review Biochemistry & Molecular Biology

Microglial subtypes: diversity within the microglial community

Vassilis Stratoulias et al.

EMBO JOURNAL (2019)

Article Clinical Neurology

A preliminary data: Evaluation of serum Galectin-3 levels in patients with Idiopathic Parkinson's Disease

Hulya Olgun Yazar et al.

JOURNAL OF CLINICAL NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease

Jian Jing Siew et al.

NATURE COMMUNICATIONS (2019)

Review Pathology

RNA Binding Proteins and the Pathogenesis of Frontotemporal Lobar Degeneration

Jeffrey W. Hofmann et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 14 (2019)

Article Immunology

Calreticulin and Galectin-3 Opsonise Bacteria for Phagocytosis by Microglia

Tom O. J. Cockram et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Clinical Neurology

Galectin-3: an emerging biomarker in stroke and cerebrovascular diseases

A. Venkatraman et al.

EUROPEAN JOURNAL OF NEUROLOGY (2018)

Review Pharmacology & Pharmacy

Galectin-3: mediator of microglia responses in injured brain

Reza Rahimian et al.

DRUG DISCOVERY TODAY (2018)

Review Biochemistry & Molecular Biology

Untangling Galectin-Driven Regulatory Circuits in Autoimmune Inflammation

Marta A. Toscano et al.

TRENDS IN MOLECULAR MEDICINE (2018)

Review Neurosciences

Microglial Lectins in Health and Neurological Diseases

Jian Jing Siew et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

Review Neurosciences

Galectin-3-Mediated Glial Crosstalk Drives Oligodendrocyte Differentiation and (Re) myelination

Laura Thomas et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2018)

Article Clinical Neurology

Identification of galectin-3 as a possible antibody target for secondary progressive multiple sclerosis

Hideaki Nishihara et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

Article Clinical Neurology

Identification of galectin-3 as a possible antibody target for secondary progressive multiple sclerosis

Hideaki Nishihara et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

Article Immunology

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Li Zhong et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2017)

Review Neurosciences

Regenerating CNS myelin - from mechanisms to experimental medicines

Robin J. M. Franklin et al.

NATURE REVIEWS NEUROSCIENCE (2017)

Article Clinical Neurology

Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins

William P. Flavin et al.

ACTA NEUROPATHOLOGICA (2017)

Article Biochemistry & Molecular Biology

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

Hadas Keren-Shaul et al.

Article Clinical Neurology

High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid Endarterectomy

Andreas Edsfeldt et al.

CEREBROVASCULAR DISEASES (2016)

Article Medical Laboratory Technology

The change of plasma galectin-3 concentrations after traumatic brain injury

Yong-Feng Shen et al.

CLINICA CHIMICA ACTA (2016)

Review Biochemistry & Molecular Biology

Energy metabolism and inflammation in brain aging and Alzheimer's disease

Fei Yin et al.

FREE RADICAL BIOLOGY AND MEDICINE (2016)

Article Immunology

Cuprizone demyelination induces a unique inflammatory response in the subventricular zone

James M. Hillis et al.

JOURNAL OF NEUROINFLAMMATION (2016)

Article Critical Care Medicine

A New Panel of Blood Biomarkers for the Diagnosis of Mild Traumatic Brain Injury/Concussion in Adults

Rongzi Shan et al.

JOURNAL OF NEUROTRAUMA (2016)

Article Clinical Neurology

Role of galectin-3 in plasma as a predictive biomarker of outcome after acute intracerebral hemorrhage

Xin-Jiang Yan et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2016)

Article Neurosciences

A polarizing question: do M1 and M2 microglia exist?

Richard M. Ransohoff

NATURE NEUROSCIENCE (2016)

Article Neurosciences

Spatio-temporal activation of caspase-8 in myeloid cells upon ischemic stroke

Johanna Rodhe et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer's Disease Model

Yaming Wang et al.

Article Biochemistry & Molecular Biology

Galectin-3 is a sensor-regulator of toll-like receptor pathways in synovial fibroblasts

Uri Arad et al.

CYTOKINE (2015)

Article Medicine, Research & Experimental

TREM2 sustains microglial expansion during aging and response to demyelination

Pietro Luigi Poliani et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Immunology

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

Antoine Lampron et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

Review Clinical Neurology

Neuroinflammation in Alzheimer's disease

Michael T. Heneka et al.

LANCET NEUROLOGY (2015)

Review Geriatrics & Gerontology

Head trauma in sport and neurodegenerative disease: an issue whose time has come?

Neil Pearce et al.

NEUROBIOLOGY OF AGING (2015)

Article Emergency Medicine

Factors that may improve outcomes of early traumatic brain injury care: prospective multicenter study in Austria

Alexandra Brazinova et al.

SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE (2015)

Article Geriatrics & Gerontology

Elevated Galectin-3 Levels in the Serum of Patients With Alzheimer's Disease

Xuexin Wang et al.

AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS (2015)

Article Biochemistry & Molecular Biology

Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease

Han-Yun Hsiao et al.

HUMAN MOLECULAR GENETICS (2014)

Article Medicine, Research & Experimental

A Decade of Research on TLR2 Discovering Its Pivotal Role in Glial Activation and Neuroinflammation in Neurodegenerative Diseases

Jin Hee Hayward et al.

Experimental Neurobiology (2014)

Article Biochemical Research Methods

Serum proteomics in amnestic mild cognitive impairment

Linda IJsselstijn et al.

PROTEOMICS (2013)

Article Multidisciplinary Sciences

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

Changyoun Kim et al.

NATURE COMMUNICATIONS (2013)

Article Biochemistry & Molecular Biology

Molecular Signatures of Amyotrophic Lateral Sclerosis Disease Progression in Hind and Forelimb Muscles of an SOD1G93A Mouse Model

Daniele Capitanio et al.

ANTIOXIDANTS & REDOX SIGNALING (2012)

Article Cell Biology

Galectin-3 is a new MerTK-specific eat-me signal

Nora B. Caberoy et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2012)

Article Neurosciences

Galectin-3 Is Required for Resident Microglia Activation and Proliferation in Response to Ischemic Injury

Melanie Lalancette-Hebert et al.

JOURNAL OF NEUROSCIENCE (2012)

Editorial Material Ophthalmology

Focus on Molecules: Galectin-3

Pablo Argueeso et al.

EXPERIMENTAL EYE RESEARCH (2011)

Article Biochemistry & Molecular Biology

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

Izumi Maezawa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Immunology

Delayed inflammatory mRNA and protein expression after spinal cord injury

Kimberly R. Byrnes et al.

JOURNAL OF NEUROINFLAMMATION (2011)

Article Clinical Neurology

Increased expression of distinct galectins in multiple sclerosis lesions

M. Stancic et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2011)

Article Biochemistry & Molecular Biology

Binding of Toxoplasma gondii Glycosylphosphatidylinositols to Galectin-3 Is Required for Their Recognition by Macrophages

Francoise Debierre-Grockiego et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Article Immunology

Galectin-3 Exerts Cytokine-Like Regulatory Actions through the JAK-STAT Pathway

Sae-Bom Jeon et al.

JOURNAL OF IMMUNOLOGY (2010)

Article Biochemical Research Methods

Galectin-3 Is a Candidate Biomarker for Amyotrophic Lateral Sclerosis: Discovery by a Proteomics Approach

Jian-Ying Zhou et al.

JOURNAL OF PROTEOME RESEARCH (2010)

Article Neurosciences

Galectin-3 contributes to neonatal hypoxic-ischemic brain injury

Christina Doverhag et al.

NEUROBIOLOGY OF DISEASE (2010)

Article Neurosciences

The Glial Nature of Embryonic and Adult Neural Stem Cells

Arnold Kriegstein et al.

Annual Review of Neuroscience (2009)

Article Neurosciences

Galectin-3 mediates post-ischemic tissue remodeling

Yi-Ping Yan et al.

BRAIN RESEARCH (2009)

Article Immunology

Galectin-3 Deficiency Reduces the Severity of Experimental Autoimmune Encephalomyelitis

Hui-Rong Jiang et al.

JOURNAL OF IMMUNOLOGY (2009)

Article Immunology

Regulation of alternative macrophage activation by galectin-3

Alison C. MacKinnon et al.

JOURNAL OF IMMUNOLOGY (2008)

Review Medicine, General & Internal

Multiple sclerosis

Alastair Compston et al.

LANCET (2008)

Article Biochemistry & Molecular Biology

Galectin-3 interacts with membrane lipids and penetrates the lipid bilayer

P Lukyanov et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

Review Oncology

Galectins as modulators of tumour progression

FT Liu et al.

NATURE REVIEWS CANCER (2005)

Article Oncology

Galectin-3, a novel binding partner of β-catenin

T Shimura et al.

CANCER RESEARCH (2004)

Review Neurosciences

Why does remyelination fail in multiple sclerosis?

RJM Franklin

NATURE REVIEWS NEUROSCIENCE (2002)