Journal
CELL DEATH & DISEASE
Volume 13, Issue 7, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s41419-022-05074-3
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Funding
- National Institutes of Health [EY030024, EY00871]
- National Institutes of Health (NEI) [EY12190]
- National Institutes of Health (NIH COBRE grant) [P30GM114731]
- BrightFocus Foundation, Inc.
- Research to Prevent Blindness, Inc.
- Oklahoma Center for Adult Stem Cell Research
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Insulin-like growth factor I (IGF-1) is a neurotrophic factor that binds to insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 is associated with various disorders. IGF-1R is expressed in the retina and plays a crucial role in photoreceptors.
Insulin-like growth factor I (IGF-1) is a neurotrophic factor and is the ligand for insulin-like growth factor 1 receptor (IGF-1R). Reduced expression of IGF-1 has been reported to cause deafness, mental retardation, postnatal growth failure, and microcephaly. IGF-1R is expressed in the retina and photoreceptor neurons; however, its functional role is not known. Global IGF-1 KO mice have age-related vision loss. We determined that conditional deletion of IGF-1R in photoreceptors and pan-retinal cells produces age-related visual function loss and retinal degeneration. Retinal pigment epithelial cell-secreted IGF-1 may be a source for IGF-1R activation in the retina. Altered retinal, fatty acid, and phosphoinositide metabolism are observed in photoreceptor and retinal cells lacking IGF-1R. Our results suggest that the IGF-1R pathway is indispensable for photoreceptor survival, and activation of IGF-1R may be an essential element of photoreceptor and retinal neuroprotection.
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