4.7 Article

The hexokinase HKDC1 interaction with the mitochondria is essential for liver cancer progression

Related references

Note: Only part of the references are listed.
Review Gastroenterology & Hepatology

Incidence of Hepatocellular Carcinoma in Patients With Nonalcoholic Fatty Liver Disease: A Systematic Review, Meta-analysis, and Meta-regression

Lorenzo A. Orci et al.

Summary: Nonalcoholic fatty liver disease (NAFLD) may be a risk factor for hepatocellular carcinoma (HCC), and this study used meta-analysis to analyze the incidence rates of HCC in NAFLD patients. The results showed that NAFLD patients with cirrhosis have a similar risk of developing HCC compared to cirrhosis patients with other causes. However, the incidence of HCC in nonalcoholic steatohepatitis or simple steatosis patients is lower.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

Letter Gastroenterology & Hepatology

Diverging Incidence Trends for Hepatocellular Carcinoma in Rural and Urban Settings in the United States

Kali Zhou et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2022)

Article Oncology

Identification of a glycolysis-related gene signature associated with clinical outcome for patients with lung squamous cell carcinoma

Ziming Xu et al.

Summary: This study developed a glycolysis-related gene signature to predict patients' survival with LUSC and explore new therapeutic targets. The model can divide patients into high- and low-risk groups, showing significant differences in overall survival, and providing new biomarkers for targeted therapy in LUSC patients.

CANCER MEDICINE (2021)

Article Gastroenterology & Hepatology

Increasing incidence of non-HBV- and non-HCV-related hepatocellular carcinoma: single-institution 20-year study

Yuko Nagaoki et al.

Summary: The study found an increase in the incidence of nonhepatitis B and nonhepatitis C viral (NBNC) hepatocellular carcinoma (HCC) between 1992 and 2018. Concurrently, patients with NBNC-HCC also showed increasing rates of type 2 diabetes mellitus, hypertension, and hyperlipidemia. Some patients underwent hepatic resection, and those with nonalcoholic steatohepatitis (NASH) had a significantly higher prevalence of cirrhosis.

BMC GASTROENTEROLOGY (2021)

Review Cardiac & Cardiovascular Systems

Role of Mitochondrial Calcium and the Permeability Transition Pore in Regulating Cell Death

Tyler M. Bauer et al.

CIRCULATION RESEARCH (2020)

Article Multidisciplinary Sciences

Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease

Maria Calvo-Rodriguez et al.

NATURE COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

The Significance of Mitochondrial Dysfunction in Cancer

Yongde Luo et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Biochemistry & Molecular Biology

Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice

Md Wasim Khan et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2019)

Review Biochemistry & Molecular Biology

Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1

Christopher J. Adams et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2019)

Article Endocrinology & Metabolism

Hepatic HKDC1 Expression Contributes to Liver Metabolism

Carolina M. Pusec et al.

ENDOCRINOLOGY (2019)

Article Cell Biology

Studies on the Tissue Localization of HKDC1, a Putative Novel Fifth Hexokinase, in Humans

Md. Wasim Khan et al.

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY (2018)

Review Cell Biology

Exploiting Metabolic Vulnerabilities of Cancer with Precision and Accuracy

Adam J. Wolpaw et al.

TRENDS IN CELL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Interaction of Mitochondria with the Endoplasmic Reticulum and Plasma Membrane in Calcium Homeostasis, Lipid Trafficking and Mitochondrial Structure

Jedrzej Szymanski et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Article Multidisciplinary Sciences

The miR-125a/HK2 axis regulates cancer cell energy metabolism reprogramming in hepatocellular carcinoma

Fangfang Jin et al.

SCIENTIFIC REPORTS (2017)

Review Oncology

Endoplasmic Reticulum-Mitochondrial Ca2+ Fluxes Underlying Cancer Cell Survival

Hristina Ivanova et al.

FRONTIERS IN ONCOLOGY (2017)

Article Biochemistry & Molecular Biology

High expression of hexokinase domain containing 1 is associated with poor prognosis and aggressive phenotype in hepatocarcinoma

Zijian Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Medicine, Research & Experimental

Role of mitochondrial dysfunction in cancer progression

Chia-Chi Hsu et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2016)

Article Cell Biology

Cell Signaling and Stress Responses

Gokhan S. Hotamisligil et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2016)

Review Multidisciplinary Sciences

Fundamentals of cancer metabolism

Ralph J. DeBerardinis et al.

SCIENCE ADVANCES (2016)

Review Biochemistry & Molecular Biology

Ca2+ homeostasis and endoplasmic reticulum (ER) stress: An integrated view of calcium signaling

Joachim Krebs et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Veterinary Sciences

Diethylnitrosamine (DEN)-induced carcinogenic liver injury in mice

R. Tolba et al.

LABORATORY ANIMALS (2015)

Review Genetics & Heredity

Physiological roles of regulated Ire1 dependent decay

Dina S. Coelho et al.

FRONTIERS IN GENETICS (2014)

Review Developmental Biology

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

Shuhui Lim et al.

DEVELOPMENT (2013)

Article Biochemistry & Molecular Biology

Overexpression of DOC-1R Inhibits Cell Cycle G1/S Transition by Repressing CDK2 Expression and Activation

Qi Liu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2013)

Article Cell Biology

Mitochondrial Ca2+ and apoptosis

Carlotta Giorgi et al.

CELL CALCIUM (2012)

Review Cell Biology

Mitochondria as sensors and regulators of calcium signalling

Rosario Rizzuto et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Article Multidisciplinary Sciences

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

David Sebastian et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Physiology

Cell Migration

Xavier Trepat et al.

COMPREHENSIVE PHYSIOLOGY (2012)

Article Biochemical Research Methods

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

Mark D. Robinson et al.

BIOINFORMATICS (2010)

Article Biochemistry & Molecular Biology

Molecular evolution of the vertebrate hexokinase gene family: Identification of a conserved fifth vertebrate hexokinase gene

David M. Irwin et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS (2008)

Review Gastroenterology & Hepatology

Management of hepatoceullular carcinoma

J Bruix et al.

HEPATOLOGY (2005)

Review Biochemistry & Molecular Biology

The key role of anaplerosis and cataplerosis for citric acid cycle function

OE Owen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Mitochondrial binding of hexokinase II inhibits Bax-induced cytochrome c release and apoptosis

JG Pastorino et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)