Journal
CELL DEATH & DISEASE
Volume 13, Issue 6, Pages -Publisher
SPRINGERNATURE
DOI: 10.1038/s41419-022-04949-9
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Funding
- National Natural Science Foundation of China [81972663, 82173055, U2004112]
- Excellent Youth Science Project of Henan Natural Science Foundation [212300410074]
- Key Scientific Research Project of Henan Higher Education Institutions [20A310024]
- Youth Talent Innovation Team Support Program of Zhengzhou University [32320290]
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Exosomal circRNAs play important roles in tumor immunity by affecting various immune cells and serving as potential prognostic and drug sensitivity markers.
Tumour immunity plays an important role in the development of cancer. Tumour immunotherapy is an important component of antitumour therapy. Exosomes, a type of extracellular vesicle, act as mediators of intercellular communication and molecular transfer and play an essential role in tumour immunity. Circular RNAs (circRNAs) are a new type of noncoding RNA that are enriched within exosomes. In this review, we describe the effects of exosomal circRNAs on various immune cells and the mechanisms of these effects, including macrophages, neutrophils, T cells, and Natural killer (NK) cells. Next, we elaborate on the latest progress of exosome extraction. In addition, the function of exosomal circRNAs as a potential prognostic and drug sensitivity marker is described. We present the great promise of exosomal circRNAs in regulating tumour immunity, predicting patient outcomes, and evaluating drug efficacy.
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