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Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells
A. Abderrahmani et al.
DIABETOLOGIA (2007)
Insulin receptors in β-cells are critical for islet compensatory growth response to insulin resistance
Terumasa Okada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment
Liam R. Brunham et al.
NATURE MEDICINE (2007)
Selective inhibition of eukaryotic translation initiation factor 2α dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic β-cell dysfunction and apoptosis
Miriam Cnop et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Pancreatic islet production of vascular endothelial growth factor-A is essential for islet vascularization, revascularization, and function
Marcela Brissova et al.
DIABETES (2006)
Formation of elongated giant mitochondria in DFO-induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1
Young-Sil Yoon et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
Umut Oezcan et al.
SCIENCE (2006)
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response
Julie Hollien et al.
SCIENCE (2006)
Islet β cell failure in type 2 diabetes
Marc Prentki et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Role of the forkhead protein FoxO1 in β cell compensation to insulin resistance
H Okamoto et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Expression of inhibin/activin subunits alpha (-α), BetaA (-βA), and BetaB (-βB) in placental tissue of normal, preeclamptic, and HELLP pregnancies
I. Mylonas et al.
ENDOCRINE PATHOLOGY (2006)
Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways
Wolf Wente et al.
DIABETES (2006)
Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas
J Fujikura et al.
CELL METABOLISM (2006)
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands
AH Lee et al.
EMBO JOURNAL (2005)
Adiponectin inhibits Toll-like receptor family-induced signaling
N Yamaguchi et al.
FEBS LETTERS (2005)
The structure of the Follistatin:Activin complex reveals antagonism of both type I and type II receptor binding
TB Thompson et al.
DEVELOPMENTAL CELL (2005)
FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction
YI Kitamura et al.
CELL METABOLISM (2005)
Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3
MD Brand et al.
CELL METABOLISM (2005)
Mechanisms of compensatory β-cell growth in insulin-resistant rats -: Roles of Akt kinase
TL Jetton et al.
DIABETES (2005)
FOXO transcription factors in cell-cycle regulation and the response to oxidative stress
Y Furukawa-Hibi et al.
ANTIOXIDANTS & REDOX SIGNALING (2005)
Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells
JS Harmon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
L Khamzina et al.
ENDOCRINOLOGY (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic β-cells
AK Cardozo et al.
DIABETES (2005)
Evidence that an isoform of Calpain-10 is a regulator of exocytosis in pancreatic beta-cells
C Marshall et al.
MOLECULAR ENDOCRINOLOGY (2005)
Inhibition of activin signaling induces pancreatic epithelial cell expansion and diminishes terminal differentiation of pancreatic β-cells
YQ Zhang et al.
DIABETES (2004)
Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets
G Kwon et al.
DIABETES (2004)
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
JD Johnson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Free fatty acids and Cytokines induce pancreatic β-cell apoptosis by different mechanisms:: Role of nuclear factor-κB and endoplasmic reticulum stress
I Kharroubi et al.
ENDOCRINOLOGY (2004)
Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell
GG Holz
DIABETES (2004)
Opposing actions of Arx and Pax4 in endocrine pancreas development
P Collombat et al.
GENES & DEVELOPMENT (2003)
IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans
A Steensberg et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)
Specific and combined effects of insulin and glucose on functional pancreatic β-cell mass in vivo in adult rats
M Paris et al.
ENDOCRINOLOGY (2003)
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake
RM Anson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Y Itoh et al.
NATURE (2003)
The evolution of β-cell dysfunction and insulin resistance in type 2 diabetes
RN Bergman et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2002)
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets -: Evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
R Lupi et al.
DIABETES (2002)
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
WC Knowler et al.
NEW ENGLAND JOURNAL OF MEDICINE (2002)
Critical role of cAMP-GEFII.Rim2 complex in incretin-potentiated insulin secretion
Y Kashima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle
F Gómez-Pinilla et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2001)
The hormone resistin links obesity to diabetes
CM Steppan et al.
NATURE (2001)
Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function
K Maedler et al.
DIABETES (2001)
Insulin regulation of β-cell function involves a feedback loop on SERCA gene expression, Ca2+ homeostasis, and insulin expression and secretion
GG Xu et al.
BIOCHEMISTRY (2000)
cAMP-GEFII is a direct target of cAMP in regulated exocytosis
N Ozaki et al.
NATURE CELL BIOLOGY (2000)
Regulated translation initiation controls stress-induced gene expression in mammalian cells
HP Harding et al.
MOLECULAR CELL (2000)
Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in β-cells
CA Aspinwall et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
T Yokota et al.
BLOOD (2000)