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Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment
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NATURE MEDICINE (2007)
Selective inhibition of eukaryotic translation initiation factor 2α dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic β-cell dysfunction and apoptosis
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JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Pancreatic islet production of vascular endothelial growth factor-A is essential for islet vascularization, revascularization, and function
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Formation of elongated giant mitochondria in DFO-induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1
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JOURNAL OF CELLULAR PHYSIOLOGY (2006)
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
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SCIENCE (2006)
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SCIENCE (2006)
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JOURNAL OF CLINICAL INVESTIGATION (2006)
Role of the forkhead protein FoxO1 in β cell compensation to insulin resistance
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JOURNAL OF CLINICAL INVESTIGATION (2006)
Expression of inhibin/activin subunits alpha (-α), BetaA (-βA), and BetaB (-βB) in placental tissue of normal, preeclamptic, and HELLP pregnancies
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ENDOCRINE PATHOLOGY (2006)
Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways
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Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas
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CELL METABOLISM (2006)
XBP-1 is required for biogenesis of cellular secretory machinery of exocrine glands
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EMBO JOURNAL (2005)
Adiponectin inhibits Toll-like receptor family-induced signaling
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FEBS LETTERS (2005)
The structure of the Follistatin:Activin complex reveals antagonism of both type I and type II receptor binding
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DEVELOPMENTAL CELL (2005)
FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction
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CELL METABOLISM (2005)
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CELL METABOLISM (2005)
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DIABETES (2005)
FOXO transcription factors in cell-cycle regulation and the response to oxidative stress
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ANTIOXIDANTS & REDOX SIGNALING (2005)
Oxidative stress-mediated, post-translational loss of MafA protein as a contributing mechanism to loss of insulin gene expression in glucotoxic beta cells
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: Possible involvement in obesity-linked insulin resistance
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ENDOCRINOLOGY (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
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SCIENCE (2005)
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic β-cells
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DIABETES (2005)
Evidence that an isoform of Calpain-10 is a regulator of exocytosis in pancreatic beta-cells
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MOLECULAR ENDOCRINOLOGY (2005)
Inhibition of activin signaling induces pancreatic epithelial cell expansion and diminishes terminal differentiation of pancreatic β-cells
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DIABETES (2004)
Signaling elements involved in the metabolic regulation of mTOR by nutrients, incretins, and growth factors in islets
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DIABETES (2004)
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets
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JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Free fatty acids and Cytokines induce pancreatic β-cell apoptosis by different mechanisms:: Role of nuclear factor-κB and endoplasmic reticulum stress
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ENDOCRINOLOGY (2004)
Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell
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DIABETES (2004)
Opposing actions of Arx and Pax4 in endocrine pancreas development
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GENES & DEVELOPMENT (2003)
IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans
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AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)
Specific and combined effects of insulin and glucose on functional pancreatic β-cell mass in vivo in adult rats
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ENDOCRINOLOGY (2003)
Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
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NATURE (2003)
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EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2002)
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets -: Evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
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DIABETES (2002)
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
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NEW ENGLAND JOURNAL OF MEDICINE (2002)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle
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EUROPEAN JOURNAL OF NEUROSCIENCE (2001)
The hormone resistin links obesity to diabetes
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NATURE (2001)
Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function
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DIABETES (2001)
Insulin regulation of β-cell function involves a feedback loop on SERCA gene expression, Ca2+ homeostasis, and insulin expression and secretion
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BIOCHEMISTRY (2000)
cAMP-GEFII is a direct target of cAMP in regulated exocytosis
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NATURE CELL BIOLOGY (2000)
Regulated translation initiation controls stress-induced gene expression in mammalian cells
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MOLECULAR CELL (2000)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
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BLOOD (2000)
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