Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 94, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2022.105140
Keywords
Inflammatory bowel disease; Gut microbiota; Pasteurized fermented milk; Functional food; Probiotics
Categories
Funding
- National Natural Science Foun-dation of China (Beijing, China) [31972083, 32001711]
- Inner Mongolia Science and Technology Major Projects [2021ZD0014]
- China Agriculture Research System of MOF
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This study found that oral administration of pasteurized probiotic fermented milk can significantly alleviate IBD symptoms, reduce inflammation, and restore the stability of the gut microbiota.
The pathogenesis of inflammatory bowel disease (IBD) is closely related to inflammatory damage and gut dysbiosis. Administering fermented milk may serve as a dietary intervention strategy of delivering bioactive substrates to consumers. This work aimed to investigate the mitigating effects of pasteurized probiotic fermented milk on dextran sulfate sodium (DSS)-induced IBD in rats. Our results showed that intragastric gavage of pasteurized probiotic fermented milk could significantly lower DAI scores, alleviate colon damage, and decrease serum tumor necrosis factor-alpha and interleukin-6 levels. Additionally, pasteurized probiotic fermented milk administration improved the intestinal microbial Richness index, accompanied by significant increases in beneficial bacteria and reduction in species related to host inflammation. The gut functional metagenome also shifted with pasteurized probiotic fermented milk intervention, showing significant enrichment in biosynthesis pathways of amino acids, nucleotides, and vitamins. In conclusion, ingesting pasteurized probiotic fermented milk alleviated IBD by reducing inflammatory response and restoring the gut microbiota.
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