4.6 Review

The role of Cdk5 in neurological disorders

Related references

Note: Only part of the references are listed.
Article Cell Biology

CDK5 inhibition improves glucose uptake in insulin-resistant neuronal cells via ERK1/2 pathway

Kapil Manglani et al.

Summary: The study demonstrates that CDK5 inhibition can improve neuronal insulin resistance and increase glucose uptake, potentially through the ERK1/2 pathway. This provides new insights into developing therapeutic strategies for neuronal insulin resistance.

CELL BIOLOGY INTERNATIONAL (2022)

Article Chemistry, Medicinal

Discovery and Optimization of Highly Selective Inhibitors of CDK5

Matthew H. Daniels et al.

Summary: This study reports the discovery of highly selective CDK5 inhibitors, which demonstrate target engagement and avoid anti-proliferative effects associated with inhibiting other CDKs in cellular assays. The compounds in this series also show promising in vivo PK profiles.

JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Biochemistry & Molecular Biology

O-GlcNAc transferase regulates glioblastoma acetate metabolism via regulation of CDK5-dependent ACSS2 phosphorylation

Lorela Ciraku et al.

Summary: This study identifies a novel mechanism in which OGT regulates acetate-dependent acetyl-CoA and lipid production by regulating phosphorylation of ACSS2 by CDK5. The OGT/CDK5/ACSS2 pathway may be a potential target for treating altered metabolic dependencies in brain tumors.

ONCOGENE (2022)

Article Medicine, Research & Experimental

Role of cyclin-dependent kinase 5 in early brain injury following experimental subarachnoid hemorrhage

Yu Ding et al.

Summary: Increasing evidence suggests that early brain injury (EBI) and apoptosis are associated with poor outcomes following subarachnoid hemorrhage (SAH). The role of Cyclin-dependent kinase 5 (Cdk5) in EBI after SAH has been investigated, and treatment with Cdk5 inhibitor roscovitine has shown significant mitigation of EBI and alleviation of cerebral edema.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2022)

Article Multidisciplinary Sciences

Nano-Honokiol ameliorates the cognitive deficits in TgCRND8 mice of Alzheimer's disease via inhibiting neuropathology and modulating gut microbiota

Chang Qu et al.

Summary: The novel honokiol nanoscale drug delivery system greatly improved the oral bioavailability of honokiol and effectively inhibited amyloid deposition, improved cognitive deficits, and attenuated neuroinflammation in Alzheimer's disease model mice. Honokiol nanoscale drug delivery system showed great potential for further development as a therapeutic agent for Alzheimer's disease treatment.

JOURNAL OF ADVANCED RESEARCH (2022)

Article Biology

Cdk5-mediated JIP1 phosphorylation regulates axonal outgrowth through Notch1 inhibition

Doo Soon Im et al.

Summary: Our study reveals a critical signaling axis involving Cdk5-JIP1-Itch-Notch1 that plays an important role in the regulation of CNS development. Further investigation into how this pathway integrates with additional pathways regulating axonal growth will enhance our understanding of normal central nervous system development and pathological conditions.

BMC BIOLOGY (2022)

Article Environmental Sciences

Phosphorylation of p53 by Cdk5 contributes to benzo[a]pyrene-induced neuronal apoptosis

Jisheng Nie et al.

Summary: The study demonstrates that Benzo[a]pyrene (B[a]P) induces neuronal apoptosis through a dose- and time-dependent manner, and the Cdk5/p53 signaling pathway may play a role in this process. The use of roscovitine, a specific Cdk5 inhibitor, shows potential in alleviating B[a]P-induced neuronal apoptosis.

ENVIRONMENTAL TOXICOLOGY (2022)

Article Biochemistry & Molecular Biology

Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission

Guan-Ting Liu et al.

Summary: This study reveals the regulatory role of neuronal endosomes in synaptic activity and identifies the importance of endosomal lipid PI(3)P in presynaptic vesicle cycling and neurotransmission.

EMBO JOURNAL (2022)

Article Neurosciences

circHIPK3 regulates apoptosis and mitochondrial dysfunction induced by ischemic stroke in mice by sponging miR-148b-3p via CDK5R1/SIRT1

Guozhong Chen et al.

Summary: circHIPK3 plays an important role in ischemic stroke by inhibiting the activity of miR-148b-3p, leading to apoptosis and mitochondrial dysfunction in brain microvascular endothelial cells.

EXPERIMENTAL NEUROLOGY (2022)

Article Neurosciences

Kai-Xin-San Inhibits Tau Pathology and Neuronal Apoptosis in Aged SAMP8 Mice

Ya-Nan Jiao et al.

Summary: This study reveals the therapeutic mechanism of the traditional Chinese medicine formula Kai-Xin-San (KXS) for Alzheimer's disease (AD), which involves the inhibition of Tau protein hyperphosphorylation, inflammation, and apoptosis, leading to improved cognitive function in AD animal models.

MOLECULAR NEUROBIOLOGY (2022)

Article Cell Biology

Visualization of trigeminal ganglion sensory neuronal signaling regulated by Cdk5

Minghan Hu et al.

Summary: The mechanisms underlying facial pain are not fully understood, but this study explores the role of Cdk5 in pain signaling and its potential as a therapeutic target. The researchers use intravital imaging to study trigeminal neuronal activities and find that a Cdk5 inhibitor can alleviate facial inflammatory pain and inflammation-induced allodynia. This suggests that Cdk5 inhibitors may be promising non-opioid candidates for pain treatment.

CELL REPORTS (2022)

Article Neurosciences

Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons

Miyuki Takahashi et al.

Summary: Cyclin-dependent kinase 5 (Cdk5) /p35 plays an important role in the developmental processes of the central nervous system. This study found that Cdk5/p35 in excitatory neurons is crucial for hippocampal synaptic plasticity and associative memory retention, while Cdk5/p35 in inhibitory neurons does not have an impact on these aspects.

MOLECULAR BRAIN (2022)

Article Pharmacology & Pharmacy

Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior

Alan Umfress et al.

Summary: Cyclin-dependent kinase 5 (Cdk5) is a crucial regulator of neuronal signal transduction and its activity is implicated in various neuropsychiatric and neurodegenerative conditions. In this study, a novel brain-penetrant Cdk5 inhibitor 25-106 was identified, which showed promising effects on behavior and has significant potential as a neurological/neuropsychiatric therapeutic.

FRONTIERS IN PHARMACOLOGY (2022)

Article Medicine, Research & Experimental

Implications of miR-148a-3p/p35/PTEN signaling in tau hyperphosphorylation and autoregulatory feedforward of Akt/CREB in Alzheimer's disease

Li Zeng et al.

Summary: This study revealed the important role and mechanism of miR-148a-3p in Alzheimer's disease, which protects neuronal cells against tau hyperphosphorylation by regulating the p35/CDK5 and PTEN/p38 MAPK pathways. Moreover, a mutual regulatory link between miR-148a-3p and PTEN was confirmed through the promotion of transcription and expression, suggesting their essential contribution to AD pathology.

MOLECULAR THERAPY-NUCLEIC ACIDS (2022)

Article Neurosciences

Melatonin ameliorates tau-related pathology via the miR-504-3p and CDK5 axis in Alzheimer's disease

Dongmei Chen et al.

Summary: The study found that melatonin can alleviate tau-related pathologies by upregulating miR-504-3p expression and targeting the p39/CDK5 axis, which may provide a potential therapeutic strategy for Alzheimer's disease.

TRANSLATIONAL NEURODEGENERATION (2022)

Article Neurosciences

Cdk5 phosphorylation-induced SIRT2 nuclear translocation promotes the death of dopaminergic neurons in Parkinson's disease

Jianguo Yan et al.

Summary: SIRT2 knockout effectively improves abnormal behavioral phenotypes in transgenic mouse models of PD. The nuclear translocation of SIRT2 promotes neuronal death, and Cdk5-mediated phosphorylation is necessary for this nuclear translocation.

NPJ PARKINSONS DISEASE (2022)

Article Biochemistry & Molecular Biology

Dendritic distribution of CDK5 mRNA and p35 mRNA, and a glutamate-responsive increase of CDK5/p25 complex contribute to tau hyperphosphorylation

Toru Tanaka et al.

Summary: This study investigates the mechanism of tau protein phosphorylation under neural excitation conditions, and reveals that the translation and hyper-activation of CDK5 are mediated by dendrite-distributed mRNA in response to glutamatergic stimulation.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2022)

Article Biochemistry & Molecular Biology

Valproic Acid-Induced Anxiety and Depression Behaviors are Ameliorated in p39 Cdk5 Activator-Deficient Mice

Miyuki Takahashi et al.

Summary: The study reveals a specific role of Cdk5-p39 in VPA-induced anxiety and depression behaviors.

NEUROCHEMICAL RESEARCH (2022)

Article Neurosciences

Downregulation of CDK5 signaling in the dorsal striatum alters striatal microcircuits implicating the association of pathologies with circadian behavior in mice

Hu Zhou et al.

Summary: Dysfunction of striatal dopaminergic circuits is associated with motor impairment and circadian disturbances related to Parkinson's disease. This study used gene editing technology to produce mice with a downregulation of the CDK5 gene, revealing the critical role of CDK5 in maintaining the striatal neural circuitry underlying motor functions and activity/rest associated with circadian rhythms.

MOLECULAR BRAIN (2022)

Article Biochemistry & Molecular Biology

Identification of small molecules against cyclin dependent kinase-5 using chemoinformatics approach for Alzheimer's disease and other tauopathies

Rohit Shukla et al.

Summary: Alzheimer's disease (AD) is a complex global disease characterized by amyloid beta and neurofibrillary tangles. This study screened compounds against CDK5 and identified two potential lead compounds through pharmacokinetics analysis.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2022)

Article Biochemistry & Molecular Biology

RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation

Dongdong Zhao et al.

Summary: In this study, RPS23RG1 was found to play a role in tauopathies by regulating the degradation of p35 and suppressing Cdk5 activation to inhibit tau hyperphosphorylation. Reduced levels of RPS23RG1 trigger aberrant Cdk5-p35 activation, leading to tau hyperphosphorylation and impaired axon outgrowth. These findings suggest that RPS23RG1 may serve as a potential therapeutic target in tauopathy disorders.

CELL DEATH AND DIFFERENTIATION (2021)

Article Neurosciences

Phosphorylation of STAT3 by axonal Cdk5 promotes axonal regeneration by modulating mitochondrial activity

Jinyeon Hwang et al.

Summary: The study reveals that Cdk5 plays a role in promoting axonal regeneration after nerve injury by modulating mitochondrial activity through STAT3 phosphorylation.

EXPERIMENTAL NEUROLOGY (2021)

Article Neurosciences

Regional specific activations of ERK1/2 and CDK5 differently regulate astroglial responses to ER stress in the rat hippocampus following status epilepticus

Duk-Shin Lee et al.

Summary: The study found that ER stress may induce reactive astrogliosis through ERK1/2-mediated CDK5 activation in the CA1 region. However, in the molecular layer of the dentate gyrus, ER stress may participate in astroglial apoptosis through ERK1/2-independent CDK5 activation following SE, a prolonged seizure activity.

BRAIN RESEARCH (2021)

Article Medicine, Research & Experimental

CDK5 inhibition protects against OGDR induced mitochondrial fragmentation and apoptosis through regulation of Drp1S616 phosphorylation

Chunli Chen et al.

Summary: This study indicates that inhibition of CDK5 can provide neuroprotection by regulating the phosphorylation of Drp1S616, mitigating mitochondrial fragmentation and apoptosis induced by cerebral ischemia. The findings help in the development of drug targeting the CDK5 signaling pathway for clinical use in treating cerebral ischemia.

LIFE SCIENCES (2021)

Article Biochemistry & Molecular Biology

Suppressing Cdk5 Activity by Luteolin Inhibits MPP+-Induced Apoptotic of Neuroblastoma through Erk/Drp1 and Fak/Akt/GSK3β Pathways

Ratchaneekorn Reudhabibadh et al.

Summary: Parkinson's disease (PD) is characterized by the progressive degeneration of dopaminergic neurons with the cause still unclear. Luteolin, a non-toxic flavonoid, has shown potential as an alternative medicine for PD due to its antioxidative and anti-apoptotic effects, as demonstrated in this study. The results suggest that luteolin can prevent neurotoxicity induced by MPP+ in neuroblastoma SH-SY5Y cells by improving cell viability and reducing apoptosis, as well as ameliorating mitochondrial dysfunction and neurite damage. Additionally, luteolin exerts its neuroprotective effects through the regulation of Cdk5-mediated Erk1/2/Drp1 and Fak/Akt/GSK3 beta pathways.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

DYRK1A Negatively Regulates CDK5-SOX2 Pathway and Self-Renewal of Glioblastoma Stem Cells

Brianna Chen et al.

Summary: The study demonstrates the important role of DYRK1A kinase in regulating the differentiation commitment of glioblastoma stem cells. Inhibiting DYRK1A insulates GSCs from differentiation-inducing signals, promoting differentiation and limiting stemness acquisition through deactivation of CDK5. This novel DYRK1A-CDK5-SOX2 pathway sheds further light on the mechanisms underlying the maintenance of glioblastoma stem cells.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Neurosciences

Inhibition of the CDK5/caspase-3 Pathway by p5-TAT Protects Hippocampal Neurogenesis and Alleviates Radiation-induced Cognitive Dysfunction

Junjun Zhang et al.

Summary: This study investigated the protective effects of inhibiting the Cdk5/caspase-3 pathway on radiation-induced cognitive dysfunction using p5-TAT, which was found to reduce Cdk5 hyperactivity, prevent inhibition of hippocampal neurogenesis and proliferation, and improve cognitive function.

NEUROSCIENCE (2021)

Article Neurosciences

L5-6 Spinal Nerve Ligation-induced Neuropathy Changes the Location and Function of Ca2+ Channels and Cdk5 and Affects the Compound Action Potential in Adjacent Intact L4 Afferent Fibers

Kimberly Gomez et al.

Summary: Voltage-gated Ca2+ channels play a crucial role in regulating cell processes and have been linked to neuropathic pain. Cdk5, a neuron-specific kinase, may phosphorylate Ca-v channels, altering their functional expression. Changes in Ca-v channels location and function in afferent fibers associated with Cdk5-mediated phosphorylation may contribute to nerve injury-induced allodynia.

NEUROSCIENCE (2021)

Article Neurosciences

Differential regulation of excitatory synaptic transmission in the hippocampus and anterior temporal lobe by cyclin dependent kinase 5 (Cdk5) in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS)

Jyotirmoy Banerjee et al.

Summary: Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) is the most common form of drug resistant epilepsy, involving differential regulation of excitatory synaptic transmission by Cdk5 in the hippocampus and anterior temporal lobe.

NEUROSCIENCE LETTERS (2021)

Article Oncology

CDK5 Knockdown inhibits proliferation and induces apoptosis and Cell Cycle Arrest in Human Glioblastoma

Yan Zhou et al.

Summary: The study found that CDK5 was significantly higher in glioblastoma than in low-grade glioma. Gene set enrichment analysis showed that some metabolism-related pathways were associated with the high CDK5 expression phenotype. In vitro experiments demonstrated that CDK5 knockdown impaired cell proliferation and colony formation ability, induced apoptosis, and caused cell cycle arrest.

JOURNAL OF CANCER (2021)

Article Biochemistry & Molecular Biology

The BRCC3 regulated by Cdk5 promotes the activation of neuronal NLRP3 inflammasome in Parkinson's disease models

Xinyu Cheng et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Phosphorylation of Tet3 by cdk5 is critical for robust activation of BRN2 during neuronal differentiation

Vinay Kumar Rao et al.

NUCLEIC ACIDS RESEARCH (2020)

Article Biochemistry & Molecular Biology

Roles of Id1/HIF-1 and CDK5/HIF-1 in cell cycle reentry induced by amyloid-beta peptide in post-mitotic cortical neuron

A-Ching Chao et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)

Article Biochemical Research Methods

Fluorescent Biosensor of CDK5 Kinase Activity in Glioblastoma Cell Extracts and Living Cells

Marion Peyressatre et al.

BIOTECHNOLOGY JOURNAL (2020)

Review Anesthesiology

The role of cyclin-dependent kinase 5 in neuropathic pain

Kimberly Gomez et al.

Article Chemistry, Multidisciplinary

Identification of Quinazolinone Analogs Targeting CDK5 Kinase Activity and Glioblastoma Cell Proliferation

Marion Peyressatre et al.

FRONTIERS IN CHEMISTRY (2020)

Article Multidisciplinary Sciences

p39-associated Cdk5 activity regulates dendritic morphogenesis

Li Ouyang et al.

SCIENTIFIC REPORTS (2020)

Article Multidisciplinary Sciences

R-Roscovitine Improves Motoneuron Function in Mouse Models for Spinal Muscular Atrophy

Rocio Tejero et al.

ISCIENCE (2020)

Article Neurosciences

Multifaceted Regulation of ALDH1A1 by Cdk5 in Alzheimer's Disease Pathogenesis

Kumar Nikhil et al.

MOLECULAR NEUROBIOLOGY (2019)

Article Cell Biology

The p35/CDK5 signaling is regulated by p75NTR in neuronal apoptosis after intracerebral hemorrhage

Tingting Zhou et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Review Medicine, General & Internal

Epilepsy in adults

Roland D. Thijs et al.

LANCET (2019)

Editorial Material Clinical Neurology

Global burden of neurological disorders: challenges and opportunities with the available data

Henrik Toft Sorensen

LANCET NEUROLOGY (2019)

Article Biochemistry & Molecular Biology

Role of Cdk5 in Kalirin7-Mediated Formation of Dendritic Spines

Ming-Xing Li et al.

NEUROCHEMICAL RESEARCH (2019)

Article Neurosciences

Amyloid-β promotes neurotoxicity by Cdk5-induced p53 stabilization

Rebeca Lapresa et al.

NEUROPHARMACOLOGY (2019)

Article Biochemistry & Molecular Biology

Cdk5 regulates N-cadherin-dependent neuronal migration during cortical development

Dong-Keun Lee et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Exploring the mechanism of PPARγ phosphorylation mediated by CDK5

H. Ribeiro Filho et al.

JOURNAL OF STRUCTURAL BIOLOGY (2019)

Article Neurosciences

The LMTK1-TBC1D9B-Rab11A Cascade Regulates Dendritic Spine Formation via Endosome Trafficking

Hironori Nishino et al.

JOURNAL OF NEUROSCIENCE (2019)

Article Neurosciences

Sex-Specific Regulation of Fear Memory by Targeted Epigenetic Editing of Cdk5

Ajinkya S. Sase et al.

BIOLOGICAL PSYCHIATRY (2019)

Article Cell Biology

Induction of CRMP-2 phosphorylation by CDK5 restricts the repair of damaged optic nerve

Xiaofan Chen et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Biochemistry & Molecular Biology

Inhibition of cyclin-dependent kinase 5 activity alleviates diabetes-related cognitive deficits

Wei Liu et al.

FASEB JOURNAL (2019)

Review Clinical Neurology

Neuropathic pain: Definition, assessment and epidemiology

D. Bouhassira

REVUE NEUROLOGIQUE (2019)

Article Medicine, Research & Experimental

Abnormal Mitochondria in a Non-human Primate Model of MPTP-induced Parkinson's Disease: Drp1 and CDK5/p25 Signaling

Junghyung Park et al.

EXPERIMENTAL NEUROBIOLOGY (2019)

Article Geriatrics & Gerontology

The Peptide-Directed Lysosomal Degradation of CDK5 Exerts Therapeutic Effects against Stroke

Ya-Fan Zhou et al.

AGING AND DISEASE (2019)

Review Biochemistry & Molecular Biology

CDK5: Key Regulator of Apoptosis and Cell Survival

Rabih Roufayel et al.

BIOMEDICINES (2019)

Article Biochemistry & Molecular Biology

Computational Simulations Identified Two Candidate Inhibitors of Cdk5/p25 to Abrogate Tau-associated Neurological Disorders

Amir Zeb et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2019)

Review Clinical Neurology

Huntington's disease: a clinical review

P. McColgan et al.

EUROPEAN JOURNAL OF NEUROLOGY (2018)

Article Medicine, Research & Experimental

Quercetin inhibits okadaic acid-induced tau protein hyperphosphorylation through the Ca2+-calpain-p25-CDK5 pathway in HT22 cells

Xiu-Yin Shen et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2018)

Review Neurosciences

Tale of the Good and the Bad Cdk5: Remodeling of the Actin Cytoskeleton in the Brain

Kavita Shah et al.

MOLECULAR NEUROBIOLOGY (2018)

Article Biochemistry & Molecular Biology

Modulation of TRPA1 channel activity by Cdk5 in sensory neurons

Michael A. Sulak et al.

CHANNELS (2018)

Review Behavioral Sciences

Epilepsy is a neurological and a systemic disorder

Alan W. C. Yuen et al.

EPILEPSY & BEHAVIOR (2018)

Article Biochemistry & Molecular Biology

The role of Cdk5-mediated Drp1 phosphorylation in A(1-42) induced mitochondrial fission and neuronal apoptosis

Miao-Yu Guo et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Review Cell Biology

Microglia after Seizures and in Epilepsy

Toshimitsu Hiragi et al.

CELLS (2018)

Article Biochemistry & Molecular Biology

Identification and characterization of a novel phosphoregulatory site on cyclin-dependent kinase 5

Brett Lee Roach et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Tropical Medicine

Neurogenesis and gliogenesis modulation in cerebral ischemia by CDK5 RNAi-based therapy

Juan Ignacio Munoz-Manco et al.

BIOMEDICA (2018)

Article Cell Biology

The O-GlcNAc Modification of CDK5 Involved in Neuronal Apoptosis Following In Vitro Intracerebral Hemorrhage

Xiaojin Ning et al.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2017)

Article Endocrinology & Metabolism

Targeting CDK5 post-stroke provides long-term neuroprotection and rescues synaptic plasticity

Johanna A. Gutierrez-Vargas et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017)

Article Neurosciences

Neuroprotection Induced by Transplanted CDK5 Knockdown Astrocytes in Global Cerebral Ischemic Rats

Andrea Becerra-Calixto et al.

MOLECULAR NEUROBIOLOGY (2017)

Review Neurosciences

A Tale of the Good and Bad: Remodeling of the Microtubule Network in the Brain by Cdk5

Kavita Shah et al.

MOLECULAR NEUROBIOLOGY (2017)

Article Pharmacology & Pharmacy

PTPN21 protects PC12 cell against oxygen-glucose deprivation by activating cdk5 through ERK1/2 signaling pathway

Ningning Cui et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2017)

Article Biochemistry & Molecular Biology

Calcium dysregulation and Cdk5-ATM pathway involved in a mouse model of fragile X- associated tremor/ataxia syndrome

Gaelle Robin et al.

HUMAN MOLECULAR GENETICS (2017)

Article Cell Biology

Nestin contributes to skeletal muscle homeostasis and regeneration

Julia Lindqvist et al.

JOURNAL OF CELL SCIENCE (2017)

Article Biochemistry & Molecular Biology

Role and regulation of p27 in neuronal apoptosis

Surbhi Jaiswal et al.

JOURNAL OF NEUROCHEMISTRY (2017)

Article Multidisciplinary Sciences

Tau secretion is correlated to an increase of Golgi dynamics

Nguyen-Vi Mohamed et al.

PLOS ONE (2017)

Article Multidisciplinary Sciences

Cdk5-dependent phosphorylation of liprinα1 mediates neuronal activity-dependent synapse development

Huiqian Huang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Medicine, General & Internal

Neuropathic pain

Luana Colloca et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Article Biochemistry & Molecular Biology

Cdk5 is required for the neuroprotective effect of transforming growth factor-β1 against cerebral ischemia-reperfusion

Wenhui Zhao et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Review Oncology

The Emerging Role of Cdk5 in Cancer

Karine Pozo et al.

TRENDS IN CANCER (2016)

Article Biochemistry & Molecular Biology

Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease

Marta Cherubini et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)

Article Medicine, General & Internal

Parkinson's disease

Lorraine V. Kalia et al.

LANCET (2015)

Article Neurosciences

Mitochondrial control by DRP1 in brain tumor initiating cells

Qi Xie et al.

NATURE NEUROSCIENCE (2015)

Editorial Material Medicine, General & Internal

Investigating intracerebral haemorrhage

Duncan Wilson et al.

BMJ-BRITISH MEDICAL JOURNAL (2015)

Editorial Material Medicine, General & Internal

Investigating intracerebral haemorrhage

Duncan Wilson et al.

BMJ-BRITISH MEDICAL JOURNAL (2015)

Article Medicine, General & Internal

Huntington disease

Gillian P. Bates et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

Article Biochemistry & Molecular Biology

CDK5 Contributes to Neuronal Apoptosis via Promoting MEF2D Phosphorylation in Rat Model of Intracerebral Hemorrhage

Kaifu Ke et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2015)

Review Biotechnology & Applied Microbiology

Cyclin-dependent kinases

Marcos Malumbres

GENOME BIOLOGY (2014)

Review Neurosciences

Kinase Signalling in Huntington's Disease

Kathryn R. Bowles et al.

JOURNAL OF HUNTINGTONS DISEASE (2014)

Review Cell Biology

Cdk5: a multifaceted kinase in neurodegenerative diseases

Zelda H. Cheung et al.

TRENDS IN CELL BIOLOGY (2012)

Article Medicine, General & Internal

Stroke Care 2 Stroke rehabilitation

Peter Langhorne et al.

LANCET (2011)

Article Multidisciplinary Sciences

Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease

Kwasi G. Mawuenyega et al.

SCIENCE (2010)

Article Multidisciplinary Sciences

Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion

Ren Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Public, Environmental & Occupational Health

Effect on trend estimates of the difference between survey respondents and non-respondents: Results from 27 populations in the WHO MONICA project

H Tolonen et al.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2005)

Review Cell Biology

A decade of CDK5

R Dhavan et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)