Journal
FRONTIERS IN CELLULAR NEUROSCIENCE
Volume 16, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncel.2022.810647
Keywords
Wallerian degeneration; macrophage; peripheral nerve injury; peripheral nerve regeneration; Dectin-1
Categories
Ask authors/readers for more resources
Dectin-1 plays a role in peripheral nerve injury, and inhibiting it can delay nerve degeneration and angiogenesis.
Dectin-1, a C-type lectin receptor, plays a role in nerve injury in the central nervous system. However, whether it plays a role in the peripheral nervous system is not well understood. Our study showed the expression of Dectin-1 on the membrane of macrophages. We also used a sciatic nerve crushing injury model to demonstrate that there was a delay in nerve degeneration-related processes such as breakdown of injured myelinated nerve fibers and formation of myelin ovoid in groups injected with whole glucan particle soluble (WGPS), a Dectin-1 antagonist. There were also fewer intraneural blood vessels in the Dectin-1 antagonist treated group. Our study suggested inhibiting Dectin-1 delayed debris clearance, nerve degeneration, and angiogenesis after peripheral nerve injury.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available