Journal
IEEE PHOTONICS JOURNAL
Volume 14, Issue 4, Pages -Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/JPHOT.2022.3184050
Keywords
Magnetometers; Atomic measurements; Magnetic shielding; Magnetic noise; Atom optics; Magnetic resonance imaging; Magnetic domains; Atomic magnetometer; drug monitoring; magnetic nanoparticle
Funding
- National Natural Science Foundation of China [U20A20219]
- Zhejiang Provincial Natural Science Foundation of China [LGF20C050001, LY20A050003]
- National Nature Science Foundation of China NSFC [61805213, 12075206, 12104400]
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A novel drug monitoring method is demonstrated using an optically pumped atomic magnetometer. The method quantifies the concentration of superparamagnetic nanoparticles in solutions through magnetorelaxometry measurement. The study also monitors drug-conjugated magnetic nanoparticles in mice to investigate drug sustained-release mechanism.
A novel drug monitoring method is experimentally demonstrated by optically pumped atomic magnetometer. An elliptically polarized single-beam spin-exchange-relaxation-free atomic magnetometer (SERF AM) is used to realize magnetorelaxometry (MRX) measurement and thereby quantify concentrations of superparamagnetic nanoparticles in solutions. Moreover, drug-conjugated magnetic nanoparticles are monitored in mice for twelve hours to study the drug sustained-release mechanism. Our results show the great potential of optically pumped atomic magnetometer for application in biophysical, pharmaceutical and medical areas, and may promote fields such as drug delivery research, virus detection, and molecule quantification.
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