4.6 Article

Development of a Genetically Engineered Bivalent Vaccine against Porcine Epidemic Diarrhea Virus and Porcine Rotavirus

Related references

Note: Only part of the references are listed.
Article Microbiology

Strategy of Developing Oral Vaccine Candidates Against Co-infection of Porcine Diarrhea Viruses Based on a Lactobacillus Delivery System

Tiantian Guo et al.

Summary: The number of co-infections with multiple porcine diarrhea viruses has been increasing. Inducing mucosal immunity through oral immunization is an effective approach for controlling these pathogens. This study developed a multi-pathogen vaccine based on a Lactobacillus vector platform and demonstrated its protective effect.

FRONTIERS IN MICROBIOLOGY (2022)

Article Virology

Epidemic and Evolutionary Characteristics of Swine Enteric Viruses in South-Central China from 2018 to 2021

Chang Li et al.

Summary: This study investigated swine enteric viruses in pig farms in south-central China and found that PEDV is the predominant pathogen causing piglet diarrhea. PEDV infection occurs mainly in relatively cold winter and spring in Hunan and Hubei provinces. The positive rate of PEDV showed an abnormal increase from 2020 to 2021, and that of PoRVA and PDCoV exhibited gradual increases from 2018 to 2021. PEDV-PoRVA and PEDV-PDCoV were the dominant co-infection modes. Genetic evolution analysis revealed that the PEDV GII-a is currently the epidemic genotype, and DY2020 has a different clade compared to other GII-a strains. The results emphasize the importance of strengthening surveillance and technical reserves for the prevention and control of piglet diarrhea.

VIRUSES-BASEL (2022)

Article Veterinary Sciences

The Complex Co-infections of Multiple Porcine Diarrhea Viruses in Local Area Based on the Luminex xTAG Multiplex Detection Method

Ying Shi et al.

Summary: This study found that various viruses caused severe diarrhea outbreaks in pig populations, with PKoV, PAstV, and PEDV being the most common viruses with a high infection rate. Multiple infections were common, and infection patterns varied among different pig farms.

FRONTIERS IN VETERINARY SCIENCE (2021)

Article Virology

Construction of a Recombinant Porcine Epidemic Diarrhea Virus Encoding Nanoluciferase for High-Throughput Screening of Natural Antiviral Products

Wan Li et al.

Summary: Porcine epidemic diarrhea virus (PEDV) is a major cause of acute enteric disease in neonatal piglets, with no approved drugs currently available. A nanoluciferase (NLuc)-based high-throughput screening (HTS) platform was developed to identify anti-PEDV compounds, resulting in the discovery of 25 compounds that significantly inhibit PEDV replication, including 7 natural antioxidants. This study provides a powerful platform for the rapid screening of promising therapeutic compounds against PEDV infection.

VIRUSES-BASEL (2021)

Article Virology

Emerging and re-emerging coronaviruses in pigs

Qiuhong Wang et al.

CURRENT OPINION IN VIROLOGY (2019)

Article Multidisciplinary Sciences

Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120

Jason Yolitz et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Infectious Diseases

Candidate new rotavirus species in Schreiber's bats, Serbia

Krisztian Banyai et al.

INFECTION GENETICS AND EVOLUTION (2017)

Review Virology

Porcine Rotaviruses: Epidemiology, Immune Responses and Control Strategies

Anastasia N. Vlasova et al.

VIRUSES-BASEL (2017)

Article Medicine, General & Internal

Rotavirus infection

Sue E. Crawford et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Article Virology

Porcine epidemic diarrhea in China

Dang Wang et al.

VIRUS RESEARCH (2016)

Article Veterinary Sciences

Emergence of porcine epidemic diarrhea virus in southern Germany

Julia Stadler et al.

BMC VETERINARY RESEARCH (2015)

Review Biotechnology & Applied Microbiology

The use of signal peptide domains as vaccine candidates

Riva Kovjazin et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2014)

Article Virology

VP6-sequence-based cutoff values as a criterion for rotavirus species demarcation

Jelle Matthijnssens et al.

ARCHIVES OF VIROLOGY (2012)

Article Microbiology

Predominance of Porcine P[23] Genotype Rotaviruses in Piglets with Diarrhea in Northern Thailand

Shoko Okitsu et al.

JOURNAL OF CLINICAL MICROBIOLOGY (2011)

Article Gastroenterology & Hepatology

Rotaviruses: From Pathogenesis to Vaccination

Harry B. Greenberg et al.

GASTROENTEROLOGY (2009)

Article Genetics & Heredity

Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence

R Kocherhans et al.

VIRUS GENES (2001)