SARS-CoV-2 Genomic Characteristics and Clinical Impact of SARS-CoV-2 Viral Diversity in Critically Ill COVID-19 Patients: A Prospective Multicenter Cohort Study

Article Immunology

Severity of Severe Acute Respiratory System Coronavirus 2 (SARS-CoV-2) Alpha Variant (B.1.1.7) in England

Daniel J. Grint et al.

Summary: The study found that the SARS-CoV-2 alpha variant is more transmissible and associated with increased rates of hospitalization and mortality compared to the wild-type virus in England between November 16, 2020 and January 11, 2021.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Infectious Diseases

Different mutations in SARS-CoV-2 associate with severe and mild outcome

Adam Nagy et al.

Summary: The study found a correlation between protein-level mutations in the SARS-CoV-2 virus and clinical outcomes, with some mutations associated with severe disease.

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS (2021)

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Article Microbiology

Emerging Severe Acute Respiratory Syndrome Coronavirus 2 Mutation Hotspots Associated With Clinical Outcomes and Transmission

Xianwu Pang et al.

Summary: Mutations in the SARS-CoV-2 genome are directly associated with clinical outcomes and pandemic, with mutations more likely to occur in mild and severe cases. Mutations associated with asymptomatic cases are mainly found in open reading frame 1ab (ORF1ab) and N genes, while mutations in mild and severe cases are more prevalent.

FRONTIERS IN MICROBIOLOGY (2021)

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Article Infectious Diseases

Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study

Dan Frampton et al.

Summary: This study describes the emergence of the B.1.1.7 variant of concern, its virological characteristics, and clinical severity in patients. Increased viral load was found in B.1.1.7 infection, but no association with severe disease was identified in the hospitalized cohort.

LANCET INFECTIOUS DISEASES (2021)

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Article Multidisciplinary Sciences

Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7

Nicholas G. Davies et al.

Summary: Studies have shown that the SARS-CoV-2 B.1.1.7 lineage is more transmissible and may cause more severe illness compared to pre-existing variants.

NATURE (2021)

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Article Biochemistry & Molecular Biology

The emergence and ongoing convergent evolution of the SARS-CoV-2 N501Y lineages

Darren P. Martin et al.

Summary: The emergence of the 501Y lineages of SARS-CoV-2 in 2020 coincided with a global shift in selective forces acting on various genes, leading to repeated convergent mutations at 35 genome sites known as the 501Y meta-signature. This meta-signature includes multiple mutation combinations that promote the persistence of diverse SARS-CoV-2 lineages in the face of increasing host immune recognition.

CELL (2021)

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Letter Infectious Diseases

The SARS-CoV-2 B.1.1.7 variant and increased clinical severity-the jury is out

Benjamin Giles et al.

Summary: The information above covers topics such as clotting issues after COVID-19 vaccination, comparing immunogenicity between different vaccines, and the relationship between neutralizing antibodies and protection from SARS-CoV-2 infection.

LANCET INFECTIOUS DISEASES (2021)

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Article Infectious Diseases

Mortality and critical care unit admission associated with the SARS-CoV-2 lineage B.1.1.7 in England: an observational cohort study

Martina Patone et al.

Summary: This study analyzed the clinical outcomes of patients infected with the new SARS-CoV-2 lineage B.1.1.7 compared to non-B.1.1.7 infections, finding that patients with B.1.1.7 were more likely to be admitted to critical care units and die within 28 days. However, for patients receiving critical care, mortality seemed to be independent of the virus strain.

LANCET INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters

Rana Abdelnabi et al.

Summary: The global COVID-19 pandemic has resulted in over 108 million infections and 2.4 million deaths within a year, with new variants of concern emerging. Research on prototypic VoC from B.1.1.7 and B.1.351 variants in hamsters revealed efficient infection of the lower respiratory tract and highlighted the need for assessing vaccine and therapeutic efficacy against these variants.

EBIOMEDICINE (2021)

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Article Infectious Diseases