Journal
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
Volume 78, Issue 3-4, Pages 113-121Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1515/znc-2022-0043
Keywords
aminoacetylenic; nitroimidazole; piperazine; synthesis
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A series of aminoacetylenic nitroimidazole piperazine hybrid compounds were synthesized via three-component reaction, and their properties and antibacterial activities were investigated.
A new series of aminoacetylenic nitroimidazole piperazine hybrid compounds were prepared via three-component reaction. Mannich-type reaction was utilized to couple the nitroimidazole containing propargylic moiety with secondary amines and formaldehyde in the presence of Cu (I) catalyst. The newly synthesized molecules 10a-10w, were characterized an ambiguously through NMR and mass spectrometry. The prepared compounds were assessed in vitro for their antibacterial activity against selected gram-positive and gram-negative bacteria. All of the compounds had shown insignificant activities toward gram-negative bacteria. While compounds 10m, 10q, 10s and 10t had shown moderate activities against the gram-positive bacteria Staphylococcus aureus, Bacillus subtilis and against fungi Escherichia coli and Proteus vulgaris.
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