Journal
VETERINARY MICROBIOLOGY
Volume 270, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.vetmic.2022.109456
Keywords
Riemerella anatipestifer; Novel beta-lactamase; RASA-1
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Funding
- National Natural Science Foundation of China [31902340]
- Natural Science Foundation of Chongqing, China [cstc2019jcyj-msxmX0532]
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A novel chromosomally-located beta-lactamase gene, bla(RASA-1), was identified in Riemerella anatipestifer RA-CH-1. The encoded RASA-1 is a class A extended-spectrum beta-lactamase (ESBL) that confers broad resistance to beta-lactams.
A novel chromosomally-located beta-lactamase gene, bla(RASA-1), was identified in Riemerella anatipestifer RA-CH-1. The RASA-1, encoded by bla(RASA-1), was a class A extended-spectrum beta-lactamase (ESBL), which shared 42.7% and 40.5% identities with the RAA-1 and CGA-1 beta-lactamase, respectively. Overexpression of RASA-1 in Escherichia coli confers broad resistance to beta-lactams and the purified native RASA-1 revealed ESBL-like hydro-lysis activity. Blasting in GenBank showed that bla(RASA-1) was exclusively detected in Riemerella anatipestifer. Moreover, sequence analysis revealed that this gene was located within the multi-resistance region of Riemerella anatipestifer genome.
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