Journal
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
Volume 21, Issue 4, Pages 701-706Publisher
PHARMACOTHERAPY GROUP
DOI: 10.4314/tjpr.v21i4.3
Keywords
Atherosclerosis; Cytokines; Vitamin D; Inflammation; TNF-alpha
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In a cell line model of inflammation, vitamin D was found to decrease the expression of pro-atherosclerotic cytokines and increase the expression of anti-atherosclerotic cytokines, potentially reducing cardiovascular risks. Further verification through in vivo studies is needed.
Purpose: To determine the effect of vitamin D on endothelial function in a cell line model of inflammation. Methods: Human saphenous vein cells were treated with 1,25-dihydroxyvitamin D3 (1,25-OHD) and/or TNF-??, and the expression levels of 20 different atherosclerotic cytokines were examined in the treated cells using a human atherosclerosis antibody array. The STRING and PANTHER analyses were also performed to determine the possible pathway interactions of these four pro-atherosclerotic and two antiResults: The expression levels of pro-atherosclerotic cytokines GM-CSF, CCL20, CCL5, and TNF-?? decreased upon 1,25-OHD administration, whereas those of anti-atherosclerotic cytokines PDGFB and Conclusion: Vitamin D could mitigate cardiovascular risks by mediating the expression of inflammatory cytokines; however, this needs to be verified via in vivo studies.
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