Compartmentalization and regulation of GTP in control of cellular phenotypes

Genetic or pharmacological inhibition of enzymes involved in GTP biosynthesis has substantial biological effects, underlining the need to better understand the function of GTP levels in regulation of cellular processes and the significance of targeting GTP biosynthesis enzymes for therapeutic intervention. Our current understanding of spatiotemporal regulation of GTP metabolism and its role in physiological and pathological cellular processes is far from complete. Novel methodologies such as genetically encoded sensors of free GTP offered insights into intracellular distribution and function of GTP molecules. In the current Review, we provide analysis of recent discoveries in the field of GTP metabolism and evaluate the key enzymes as molecular targets.

Automated summary

Inhibition of enzymes involved in GTP biosynthesis has significant effects on biological processes. However, our understanding of the regulation of GTP metabolism and its role in cellular processes is incomplete. Novel methodologies have provided insights into the distribution and function of GTP molecules. This review analyzes recent discoveries in GTP metabolism and evaluates key enzymes as molecular targets.