Journal
TRENDS IN MICROBIOLOGY
Volume 30, Issue 12, Pages 1146-1159Publisher
CELL PRESS
DOI: 10.1016/j.tim.2022.05.010
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In this review, the available literature is summarized to address questions regarding the function and presence of the biosynthetic gene cluster coding for colibactin, as well as its distribution in commensal and probiotic strains of Escherichia coli and other bacterial species.
The structure and mode of action of colibactin with its potential involvement in cancer have been extensively studied but little is known about the intrinsic function of the biosynthetic gene cluster, coding for colibactin, as a bacterial genotoxin. Paradoxically, this pathogenicity island is also found in commensal and probiotic strains of Escherichia coli and in bacterial species colonizing olive trees and the digestive tract of bees. In this review, we summarize the available literature to address the following key questions. What does this genomic island really encode? What explains the extensive dissemination of this genetically mobile element? What do we really know about the biosynthetic and secretory pathways of colibactin? What is its inherent target/function?
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