Journal
TRENDS IN IMMUNOLOGY
Volume 43, Issue 9, Pages 693-695Publisher
CELL PRESS
DOI: 10.1016/j.it.2022.07.009
Keywords
-
Categories
Funding
- European Research Council (AdG grant MEDICI) [692789]
- European Research Council (ERC) [692789] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Mutations in DNMT3A and TET2, regulators of DNA methylation, are linked to clonal hematopoiesis and increased risk of cardiovascular disorders. Cobo et al. discovered that the loss of mitochondrial integrity, dispersion of mitochondrial DNA, and activation of ISGs in macrophages contribute to these associations.
Mutations in two antagonistic regulators of DNA methylation, DNMT3A and TET2, are associated with clonal hematopoiesis and increased risk of cardiovascular disorders. Recently, Cobo et al. traced the mechanistic bases for such links to loss of mitochondrial integrity, cytoplasmic dispersion of mitochondrial DNA, and the subsequent activation of interferon-stimulated genes (ISGs) in macrophages.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available