Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 47, Issue 12, Pages 1009-1022Publisher
CELL PRESS
DOI: 10.1016/j.tibs.2022.06.007
Keywords
-
Categories
Funding
- US Public Health Service [R35CA232128, P01CA203655]
- American Cancer Society Postdoctoral Fellowship [PF-22-040-01-ET]
- Leibniz Institute on Aging -Fritz Lipmann Institute (FLI), Jena, Germany
- Federal Government of Germany
- State of Thuringia
Ask authors/readers for more resources
Cell cycle-dependent gene transcription is tightly regulated by multiple complexes, controlling gene expression during G1/S and G2/M phases to fulfill different functions in processes such as DNA synthesis and mitosis.
Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB):E2F and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin-dependent kinase (CDK) phosphorylation of RB and DREAM allows for the expression of two gene sets. The first set of genes, with peak expression in G1/S, is activated by E2F transcription factors (TFs) and is required for DNA synthesis. The second set, with maximum expression during G2/M, is required for mitosis and is coordinated by the MuvB complex, together with B-MYB and Forkhead box M1 (FOXM1). In this review, we summarize the key findings that established the distinct control mechanisms regulating G1/S and G2/M gene expression in mammals and discuss recent advances in the understanding of the temporal control of these genes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available