Related references
Note: Only part of the references are listed.NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosis
Poulomi Banerjee et al.
JOURNAL OF PATHOLOGY (2022)
Longitudinal Analysis Suggests Epstein--Barr as Cause of Multiple Sclerosis
[Anonymous]
CLINICAL PHARMACOLOGY & THERAPEUTICS (2022)
Novel Small-Molecule Inhibitor of NLRP3 Inflammasome Reverses Cognitive Impairment in an Alzheimer's Disease Model
Muhammad Haseeb et al.
ACS CHEMICAL NEUROSCIENCE (2022)
Mitochondrial electron transport chain is necessary for NLRP3 inflammasome activation
Leah K. Billingham et al.
NATURE IMMUNOLOGY (2022)
Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson's disease
Nikhil Panicker et al.
NEURON (2022)
NLRP3 and pyroptosis blockers for treating inflammatory diseases
Rebecca C. Coll et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2022)
AGE-TXNIP axis drives inflammation in Alzheimer's by targeting Aβ to mitochondria in microglia
Oualid Sbai et al.
CELL DEATH & DISEASE (2022)
Assembly of recombinant tau into filaments identical to those of Alzheimer's disease and chronic traumatic encephalopathy
Sofia Lovestam et al.
ELIFE (2022)
GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer's Disease
Jahirul Islam et al.
FRONTIERS IN IMMUNOLOGY (2022)
The AIM2 inflammasome is activated in astrocytes during the late phase of EAE
William E. Barclay et al.
JCI INSIGHT (2022)
Increased pyroptosis activation in white matter microglia is associated with neuronal loss in ALS motor cortex
Evelien Van Schoor et al.
ACTA NEUROPATHOLOGICA (2022)
Leveraging the preformed fibril model to distinguish between alpha-synuclein inclusion- and nigrostriatal degeneration-associated immunogenicity
Anna C. Stoll et al.
NEUROBIOLOGY OF DISEASE (2022)
Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis
Kjetil Bjornevik et al.
SCIENCE (2022)
Plasma-borne indicators of inflammasome activity in Parkinson's disease patients
Faith L. Anderson et al.
NPJ PARKINSONS DISEASE (2021)
Systemic inflammasome activation and pyroptosis associate with the progression of amnestic mild cognitive impairment and Alzheimer's disease
Wenjuan Rui et al.
JOURNAL OF NEUROINFLAMMATION (2021)
α-Synuclein evokes NLRP3 inflammasome-mediated IL-1β secretion from primary human microglia
Adrianne F. Pike et al.
GLIA (2021)
Inflammasome in ALS Skeletal Muscle: NLRP3 as a Potential Biomarker
Leticia Moreno-Garcia et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)
AIM2 controls microglial inflammation to prevent experimental autoimmune encephalomyelitis
Chunmei Ma et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2021)
Inhibition of NLRP3 inflammasome by glibenclamide attenuated dopaminergic neurodegeneration and motor deficits in paraquat and maneb-induced mouse Parkinson's disease model
Xiaofei Qiu et al.
TOXICOLOGY LETTERS (2021)
Inflammaging and neurodegenerative diseases: Role of NLRP3 inflammasome activation in brain atherosclerotic vascular disease
Stefania Cicolari et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2021)
Microglial NLRP3 Inflammasome Activation upon TLR2 and TLR5 Ligation by Distinct α-Synuclein Assemblies
Hannah Scheiblich et al.
JOURNAL OF IMMUNOLOGY (2021)
Resolvin D2 suppresses NLRP3 inflammasome by promoting autophagy in macrophages
Lijun Cao et al.
EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation
Pan Pan et al.
NATURE COMMUNICATIONS (2021)
Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88-and NLRP3-ASC-inflammasome pathway
Shanya Jiang et al.
CELL REPORTS (2021)
The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins
Vandana Deora et al.
GLIA (2020)
Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson's disease
Zheng Fan et al.
JOURNAL OF NEUROINFLAMMATION (2020)
Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis
Xue Zhang et al.
AGING-US (2020)
NLRP3 inflammasome as prognostic factor and therapeutic target in primary progressive multiple sclerosis patients
Sunny Malhotra et al.
BRAIN (2020)
Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype
Baohua Hou et al.
CELL DEATH & DISEASE (2020)
β-Amyloid Clustering around ASC Fibrils Boosts Its Toxicity in Microglia
Lea L. Friker et al.
CELL REPORTS (2020)
Role of Resolvins in the Inflammatory Resolution of Neurological Diseases
Chunrong Li et al.
FRONTIERS IN PHARMACOLOGY (2020)
Amyotrophic lateral sclerosis: a clinical review
P. Masrori et al.
EUROPEAN JOURNAL OF NEUROLOGY (2020)
The regulation of the ZBP1-NLRP3 inflammasome and its implications in pyroptosis, apoptosis, and necroptosis (PANoptosis)
Min Zheng et al.
IMMUNOLOGICAL REVIEWS (2020)
The Inflammasome Signaling Proteins ASC and IL-18 as Biomarkers of Psoriasis
Mahtab Forouzandeh et al.
FRONTIERS IN PHARMACOLOGY (2020)
The Inflammasome Adaptor Protein ASC in Mild Cognitive Impairment and Alzheimer’s Disease
Xavier O. Scott et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
New mechanism of nerve injury in Alzheimer's disease: β-amyloid-induced neuronal pyroptosis
Chenyang Han et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)
Slc6a3-dependent expression of a CAPS-associatedNlrp3allele results in progressive behavioral abnormalities and neuroinflammation in aging mice
Katharine M. von Herrmann et al.
JOURNAL OF NEUROINFLAMMATION (2020)
Coronavirus Disease 2019 and Parkinsonism: A Non-post-encephalitic Case
Ingrid Faber et al.
MOVEMENT DISORDERS (2020)
Beta-amyloid activates NLRP3 inflammasome via TLR4 in mouse microglia
Yang Liu et al.
NEUROSCIENCE LETTERS (2020)
Revisiting the Idea That Amyloid-β Peptide Acts as an Agonist for P2X7
Lucka Bibic et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)
Inflammasome Proteins as Inflammatory Biomarkers of Age-Related Macular Degeneration
Cailey Weaver et al.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY (2020)
Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease
Xinwen Zhang et al.
SCIENCE ADVANCES (2020)
A blood-brain barrier overview on structure, function, impairment, and biomarkers of integrity
Hossam Kadry et al.
FLUIDS AND BARRIERS OF THE CNS (2020)
Dapansutrile, an oral selective NLRP3 inflammasome inhibitor, for treatment of gout flares: an open-label, dose-adaptive, proof-of-concept, phase 2a trial
Viola Kluck et al.
LANCET RHEUMATOLOGY (2020)
The gasdermins, a protein family executing cell death and inflammation
Petr Broz et al.
NATURE REVIEWS IMMUNOLOGY (2020)
MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration
Eunju Lee et al.
CELL DEATH AND DIFFERENTIATION (2019)
Single-cell analysis of pyroptosis dynamics reveals conserved GSDMD-mediated subcellular events that precede plasma membrane rupture
Nathalia M. de Vasconcelos et al.
CELL DEATH AND DIFFERENTIATION (2019)
α-Synuclein misfolding and aggregation: Implications in Parkinson's disease pathogenesis
Surabhi Mehra et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2019)
The prevalence of MS in the United States A population-based estimate using health claims data
Mitchell T. Wallin et al.
NEUROLOGY (2019)
A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinson's disease
Jill A. Hollenbach et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Is Resolution the End of Inflammation?
Karen T. Feehan et al.
TRENDS IN MOLECULAR MEDICINE (2019)
Caspase-11, a specific sensor for intracellular lipopolysaccharide recognition, mediates the non-canonical inflammatory pathway of pyroptosis
Xiaoli Huang et al.
CELL AND BIOSCIENCE (2019)
Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia
Nikhil Panicker et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2019)
MCC950 directly targets the NLRP3 ATP- hydrolysis motif for inflammasome inhibition
Rebecca C. Coll et al.
NATURE CHEMICAL BIOLOGY (2019)
Dynamic Properties of Human α-Synuclein Related to Propensity to Amyloid Fibril Formation
Satoru Fujiwara et al.
JOURNAL OF MOLECULAR BIOLOGY (2019)
Knockdown of the AIM2 molecule attenuates ischemia-reperfusion-induced spinal neuronal pyroptosis by inhibiting AIM2 inflammasome activation and subsequent release of cleaved caspase-1 and IL-1β
Xiao-Qian Li et al.
NEUROPHARMACOLOGY (2019)
Rapid and Sustained Long-Term Efficacy and Safety of Canakinumab in Patients With Cryopyrin-Associated Periodic Syndrome Ages Five Years and Younger
Paul A. Brogan et al.
ARTHRITIS & RHEUMATOLOGY (2019)
Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis
Sheng Li et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2019)
NLRP3 inflammasome promotes diabetes-induced endothelial inflammation and atherosclerosis
Zhaofei Wan et al.
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY (2019)
NLRP3 inflammasome activation drives tau pathology
Christina Ising et al.
NATURE (2019)
Molecular Pathogenesis of the Tauopathies
Jurgen Gotz et al.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 14 (2019)
OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis
Alba Sanchez-Fernandez et al.
FRONTIERS IN IMMUNOLOGY (2019)
Rapamycin combined with MCC950 to treat multiple sclerosis in experimental autoimmune encephalomyelitis
Ling Xu et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2019)
Intrastriatal injection of preformed alpha-synuclein fibrils alters central and peripheral immune cell profiles in non-transgenic mice
Rachael H. Earls et al.
JOURNAL OF NEUROINFLAMMATION (2019)
Microparticulate P2X7 and GSDM-D mediated regulation of functional IL-1 release
Srabani Mitra et al.
PURINERGIC SIGNALLING (2019)
Amentoflavone suppresses amyloid β1-42 neurotoxicity in Alzheimer's disease through the inhibition of pyroptosis
Ningning Zhao et al.
LIFE SCIENCES (2019)
Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo
Ilie-Cosmin Stancu et al.
ACTA NEUROPATHOLOGICA (2019)
NLRP3 Inflammasome Activation in a Transgenic Amyotrophic Lateral Sclerosis Model
Agnese Gugliandolo et al.
INFLAMMATION (2018)
Peroxynitrite Activates the NLRP3 Inflammasome Cascade in SOD1(G93A) Mouse Model of Amyotrophic Lateral Sclerosis
Ilaria Bellezza et al.
MOLECULAR NEUROBIOLOGY (2018)
Pharmacological inhibition of the NLRP3 inflammasome as a potential target for multiple sclerosis induced central neuropathic pain
Nemat Khan et al.
INFLAMMOPHARMACOLOGY (2018)
Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3
Jialei Zhu et al.
CELL DEATH AND DIFFERENTIATION (2018)
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Lorenzo Galluzzi et al.
CELL DEATH AND DIFFERENTIATION (2018)
The Gasdermin-D pore acts as a conduit for IL-1 secretion in mice
Rosalie Heilig et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2018)
The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages
Charles L. Evavold et al.
IMMUNITY (2018)
Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration
Megan F. Duffy et al.
JOURNAL OF NEUROINFLAMMATION (2018)
Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson's disease
Chen Qiao et al.
JOURNAL OF NEUROINFLAMMATION (2018)
Inflammasome Proteins As Biomarkers of Multiple Sclerosis
Robert W. Keane et al.
FRONTIERS IN NEUROLOGY (2018)
α1-antitrypsin mitigates NLRP3-inflammasome activation in amyloid β1-42-stimulated murine astrocytes
Taraneh Ebrahimi et al.
JOURNAL OF NEUROINFLAMMATION (2018)
Cryo-EM structure of the gasdermin A3 membrane pore
Jianbin Ruan et al.
NATURE (2018)
Inflammasome signalling in brain function and neurodegenerative disease
Michael T. Heneka et al.
NATURE REVIEWS NEUROSCIENCE (2018)
NLRP3 inflammasome activation in inflammaging
Eicke Latz et al.
SEMINARS IN IMMUNOLOGY (2018)
Inflammasomes: An Emerging Mechanism Translating Environmental Toxicant Exposure Into Neuroinflammation in Parkinson's Disease
Faith L. Anderson et al.
TOXICOLOGICAL SCIENCES (2018)
Inflammasome Proteins in Serum and Serum-Derived Extracellular Vesicles as Biomarkers of Stroke
Nadine Kerr et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)
Assessment of ASC specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: an observational cohort study
Ashley A. Basiorka et al.
LANCET HAEMATOLOGY (2018)
Inflammasome proteins as biomarkers of traumatic brain injury
Nadine Kerr et al.
PLOS ONE (2018)
ESCRT-dependent membrane repair negatively regulates pyroptosis downstream of GSDMD activation
Sebastian Ruhl et al.
SCIENCE (2018)
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice
Richard Gordon et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
Vitamin D and Multiple Sclerosis: A Comprehensive Review
Martina B. Sintzel et al.
NEUROLOGY AND THERAPY (2018)
NLRP3 expression in mesencephalic neurons and characterization of a rare NLRP3 polymorphism associated with decreased risk of Parkinson's disease
Katharine M. von Herrmann et al.
NPJ PARKINSONS DISEASE (2018)
Evidence of inflammasome activation and formation of monocyte-derived ASC specks in HIV-1 positive patients
Fareed Ahmad et al.
AIDS (2018)
Prevalence of Parkinson's disease across North America
C. Marras et al.
NPJ PARKINSONS DISEASE (2018)
High Glucocorticoid Levels During Gestation Activate the Inflammasome in Hippocampal Oligodendrocytes of the Offspring
Carola J. Maturana et al.
DEVELOPMENTAL NEUROBIOLOGY (2017)
Inflammasome-Derived Exosomes Activate NF-kappa B Signaling in Macrophages
Yuehui Zhang et al.
JOURNAL OF PROTEOME RESEARCH (2017)
Caspase-1 Deficiency Alleviates Dopaminergic Neuronal Death via Inhibiting Caspase-7/AIF Pathway in MPTP/p Mouse Model of Parkinson's Disease
Chen Qiao et al.
MOLECULAR NEUROBIOLOGY (2017)
NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes
Leslie Freeman et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2017)
Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease
Carmen Venegas et al.
NATURE (2017)
Nlrp3 Is Required for Inflammatory Changes and Nigral Cell Loss Resulting From Chronic Intragastric Rotenone Exposure in Mice
Eileen M. Martinez et al.
TOXICOLOGICAL SCIENCES (2017)
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
Jianjin Shi et al.
TRENDS IN BIOCHEMICAL SCIENCES (2017)
Inflammasome Priming in Sterile Inflammatory Disease
Meghana N. Patel et al.
TRENDS IN MOLECULAR MEDICINE (2017)
Extracellular ATP Activates the NLRP3 Inflammasome and Is an Early Danger Signal of Skin Allograft Rejection
Joaquin Amores-Iniesta et al.
CELL REPORTS (2017)
Amyotrophic lateral sclerosis
Orla Hardiman et al.
NATURE REVIEWS DISEASE PRIMERS (2017)
AIM2 Inflammasome-Mediated Pyroptosis in Enterovirus A71Infected Neuronal Cells Restricts Viral Replication
Thinesshwary Yogarajah et al.
SCIENTIFIC REPORTS (2017)
Development and Characterization of a Hydroxyl-Sulfonamide Analogue, 5-Chloro-N-[2-(4-hydroxysulfamoyl-phenyl)-ethyl]-2-methoxy-benzamide, as a Novel NLRP3 lnflammasome Inhibitor for Potential Treatment of Multiple Sclerosis
Chunqing Guo et al.
ACS CHEMICAL NEUROSCIENCE (2017)
Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins
William P. Flavin et al.
ACTA NEUROPATHOLOGICA (2017)
Inflammasome activation in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE)
William Barclay et al.
BRAIN PATHOLOGY (2017)
Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice
C. Dempsey et al.
BRAIN BEHAVIOR AND IMMUNITY (2017)
The Cellular Phase of Alzheimer's Disease
Bart De Strooper et al.
CELL (2016)
Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation
Vicky Lampropoulou et al.
CELL METABOLISM (2016)
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
Lorenzo Sborgi et al.
EMBO JOURNAL (2016)
The amyloid hypothesis of Alzheimer's disease at 25years
Dennis J. Selkoe et al.
EMBO MOLECULAR MEDICINE (2016)
Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome
Chuansheng Guo et al.
IMMUNITY (2016)
Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages
Elina Valimaki et al.
JOURNAL OF IMMUNOLOGY (2016)
Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease
Julien Couturier et al.
JOURNAL OF NEUROINFLAMMATION (2016)
The NLRP3 and NLRP1 inflammasomes are activated in Alzheimer's disease
Marina Saresella et al.
MOLECULAR NEURODEGENERATION (2016)
Pore-forming activity and structural autoinhibition of the gasdermin family
Jingjin Ding et al.
NATURE (2016)
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Xing Liu et al.
NATURE (2016)
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
Yuan He et al.
NATURE (2016)
An interferon-β-resistant and NLRP3 inflammasome-independent subtype of EAE with neuronal damage
Makoto Inoue et al.
NATURE NEUROSCIENCE (2016)
Resolution of inflammation: a new therapeutic frontier
James N. Fullerton et al.
NATURE REVIEWS DRUG DISCOVERY (2016)
GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
Robin A. Aglietti et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein
Wei Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Mechanism and Regulation of NLRP3 Inflammasome Activation
Yuan He et al.
TRENDS IN BIOCHEMICAL SCIENCES (2016)
Hypoxia primes human normal prostate epithelial cells and cancer cell lines for the NLRP3 and AIM2 inflammasome activation
Ravichandran Panchanathan et al.
ONCOTARGET (2016)
Inflammasomes: mechanism of assembly, regulation and signalling
Petr Broz et al.
NATURE REVIEWS IMMUNOLOGY (2016)
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
Wan-ting He et al.
CELL RESEARCH (2015)
TDP-43 activates microglia through NF-κB and NLRP3 inflammasome
Weihua Zhao et al.
EXPERIMENTAL NEUROLOGY (2015)
NLRP3 Inflammasome Is Expressed by Astrocytes in the SOD1 Mouse Model of ALS and in Human Sporadic ALS Patients
Sonja Johann et al.
GLIA (2015)
Rotenone-induced Impairment of Mitochondrial Electron Transport Chain Confers a Selective Priming Signal for NLRP3 Inflammasome Activation
Ji-Hee Won et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
被撤回的出版物: UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis (Retracted article. See vol. 133, 2023)
Jong-Seok Moon et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Intracellular ATP Decrease Mediates NLRP3 Inflammasome Activation upon Nigericin and Crystal Stimulation
Johji Nomura et al.
JOURNAL OF IMMUNOLOGY (2015)
NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model
Chen-Chen Tan et al.
JOURNAL OF NEUROINFLAMMATION (2015)
Role of the innate and adaptive immune responses in the course of multiple sclerosis
Bernhard Hemmer et al.
LANCET NEUROLOGY (2015)
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki et al.
NATURE (2015)
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Jianjin Shi et al.
NATURE (2015)
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Rebecca C. Coll et al.
NATURE MEDICINE (2015)
MEMBRANE REPAIR: MECHANISMS AND PATHOPHYSIOLOGY
Sandra T. Cooper et al.
PHYSIOLOGICAL REVIEWS (2015)
Microglial cell dysregulation in brain aging and neurodegeneration
Rommy von Bernhardi et al.
FRONTIERS IN AGING NEUROSCIENCE (2015)
Neuroinflammation in Parkinson's disease and its potential as therapeutic target
Qinqin Wang et al.
TRANSLATIONAL NEURODEGENERATION (2015)
NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes
Audrey Gustin et al.
PLOS ONE (2015)
Expanding spectrum of neurologic manifestations in patients with NLRP3 low-penetrance mutations
Elisabeth Schuh et al.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2015)
Most Human Non-GCIMP Glioblastoma Subtypes Evolve from a Common Proneural-like Precursor Glioma
Tatsuya Ozawa et al.
CANCER CELL (2014)
Moderate Hypoxia Potentiates Interleukin-1β Production in Activated Human Macrophages
Eduardo J. Folco et al.
CIRCULATION RESEARCH (2014)
The Lysosome Rupture-activated TAK1-JNK Pathway Regulates NLRP3 Inflammasome Activation
Masahiro Okada et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Pyroptotic neuronal cell death mediated by the AIM2 inflammasome
Stephanie E. Adamczak et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2014)
Cerebrospinal fluid IL-1β correlates with cortical pathology load in multiple sclerosis at clinical onset
Dario Seppi et al.
JOURNAL OF NEUROIMMUNOLOGY (2014)
Cerebrospinal fluid detection of interleukin-1β in phase of remission predicts disease progression in multiple sclerosis
Silvia Rossi et al.
JOURNAL OF NEUROINFLAMMATION (2014)
Interleukin 18 gene polymorphism is a risk factor for multiple sclerosis
Sevim Karakas Celik et al.
MOLECULAR BIOLOGY REPORTS (2014)
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response
Alberto Baroja-Mazo et al.
NATURE IMMUNOLOGY (2014)
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation
Bernardo S. Franklin et al.
NATURE IMMUNOLOGY (2014)
Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation
Alexander K. Buell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer's disease
M-S Tan et al.
CELL DEATH & DISEASE (2014)
IKKα negatively regulates ASC-dependent inflammasome activation
Bradley N. Martin et al.
NATURE COMMUNICATIONS (2014)
Amyloid-β and Tau The Trigger and Bullet in Alzheimer Disease Pathogenesis
George S. Bloom
JAMA NEUROLOGY (2014)
Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility
Han Xiao et al.
CIRCULATION (2013)
Multiple sclerosis: association with the interleukin-1 gene family polymorphisms in the Turkish population
Nihal Isik et al.
INTERNATIONAL JOURNAL OF NEUROSCIENCE (2013)
Peripheral inflammation in neurodegeneration
Ulrike Traeger et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2013)
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
Michael T. Heneka et al.
NATURE (2013)
Incidence and Prevalence of Multiple Sclerosis in the Americas: A Systematic Review
Charity Evans et al.
NEUROEPIDEMIOLOGY (2013)
Triggering of Inflammasome by Aggregated α-Synuclein, an Inflammatory Response in Synucleinopathies
Gaia Codolo et al.
PLOS ONE (2013)
Critical Role of Regulator G-Protein Signaling 10 (RGS10) in Modulating Macrophage M1/M2 Activation
Jae-Kyung Lee et al.
PLOS ONE (2013)
Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke
D. Yang-Wei Fann et al.
CELL DEATH & DISEASE (2013)
On the subject of rigor in the study of amyloid beta-protein assembly
David B. Teplow
ALZHEIMERS RESEARCH & THERAPY (2013)
Activation and regulation of the inflammasomes
Eicke Latz et al.
NATURE REVIEWS IMMUNOLOGY (2013)
Identifying prodromal Parkinson's disease: Pre-Motor disorders in Parkinson's disease
Ronald B. Postuma et al.
MOVEMENT DISORDERS (2012)
Inflammasomes in health and disease
Till Strowig et al.
NATURE (2012)
NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis
Makoto Inoue et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
Kelvin C. Luk et al.
SCIENCE (2012)
Interferon-β Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome
Makoto Inoue et al.
SCIENCE SIGNALING (2012)
Viral and Inflammatory Triggers of Neurodegenerative Diseases
Michela Deleidi et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Smoking: effects on multiple sclerosis susceptibility and disease progression
Dean M. Wingerchuk
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS (2012)
Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
Charles A. Dinarello
BLOOD (2011)
Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation
Greta Guarda et al.
IMMUNITY (2011)
Cutting Edge: Reactive Oxygen Species Inhibitors Block Priming, but Not Activation, of the NLRP3 Inflammasome
Franz Bauernfeind et al.
JOURNAL OF IMMUNOLOGY (2011)
Regulator of G-Protein Signaling-10 Negatively Regulates NF-κB in Microglia and Neuroprotects Dopaminergic Neurons in Hemiparkinsonian Rats
Jae-Kyung Lee et al.
JOURNAL OF NEUROSCIENCE (2011)
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies
Michael A. Nalls et al.
LANCET (2011)
A role for mitochondria in NLRP3 inflammasome activation
Rongbin Zhou et al.
NATURE (2011)
Non-canonical inflammasome activation targets caspase-11
Nobuhiko Kayagaki et al.
NATURE (2011)
Use of ibuprofen and risk of Parkinson disease
Xiang Gao et al.
NEUROLOGY (2011)
Clinical Progression in Parkinson Disease and the Neurobiology of Axons
Hsiao-Chun Cheng et al.
ANNALS OF NEUROLOGY (2010)
Trafficking of immune cells in the central nervous system
Emma H. Wilson et al.
JOURNAL OF CLINICAL INVESTIGATION (2010)
Cutting Edge: Critical Role for PYCARD/ASC in the Development of Experimental Autoimmune Encephalomyelitis
Patrick J. Shaw et al.
JOURNAL OF IMMUNOLOGY (2010)
NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses
Denis Gris et al.
JOURNAL OF IMMUNOLOGY (2010)
The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18
Sushmita Jha et al.
JOURNAL OF NEUROSCIENCE (2010)
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
Taye H. Hamza et al.
NATURE GENETICS (2010)
Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis
Felix Meissner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
Jurg Tschopp et al.
NATURE REVIEWS IMMUNOLOGY (2010)
How mitochondria produce reactive oxygen species
Michael P. Murphy
BIOCHEMICAL JOURNAL (2009)
Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
Mohamed Lamkanfi et al.
JOURNAL OF CELL BIOLOGY (2009)
Neuronal death in Alzheimer's disease and therapeutic opportunities
Rossen Donev et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)
Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression
Franz G. Bauernfeind et al.
JOURNAL OF IMMUNOLOGY (2009)
CNS Infiltration of Peripheral Immune Cells: D-Day for Neurodegenerative Disease?
Kavon Rezai-Zadeh et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2009)
The analysis of IL-1 beta and its naturally occurring inhibitors in multiple sclerosis: The elevation of IL-1 receptor antagonist and IL-1 receptor type II after steroid therapy
Irena Dujmovic et al.
JOURNAL OF NEUROIMMUNOLOGY (2009)
Initial clinical manifestations of Parkinson's disease: features and pathophysiological mechanisms
Maria C. Rodriguez-Oroz et al.
LANCET NEUROLOGY (2009)
Brain multiple sclerosis-like lesions in a patient with Muckle-Wells syndrome
Sandrine Compeyrot-Lacassagne et al.
RHEUMATOLOGY (2009)
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Annett Halle et al.
NATURE IMMUNOLOGY (2008)
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Manuela Neumann et al.
SCIENCE (2006)
The aggregation and fibrillation of α-synuclein
Anthony L. Fink
ACCOUNTS OF CHEMICAL RESEARCH (2006)
Cryopyrin activates the inflammasome in response to toxins and ATP
S Mariathasan et al.
NATURE (2006)
Medical progress: Multiple sclerosis - The plaque and its pathogenesis
EM Frohman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2006)
Resolution of inflammation: The beginning programs the end
CN Serhan et al.
NATURE IMMUNOLOGY (2005)
Temporal relationship between elevation of Epstein-Barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis
LI Levin et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2005)
IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation
T Lawrence et al.
NATURE (2005)
Apoptosis, pyroptosis, and necrosis: Mechanistic description of dead and dying eukaryotic cells
SL Fink et al.
INFECTION AND IMMUNITY (2005)
Molecular pathogenesis of Parkinson disease
JL Eriksen et al.
ARCHIVES OF NEUROLOGY (2005)
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis:: an [11C](R)-PK11195 positron emission tomography study
MR Turner et al.
NEUROBIOLOGY OF DISEASE (2004)
α-synuclein locus duplication as a cause of familial Parkinson's disease
MC Chartier-Harlin et al.
LANCET (2004)
Increased expression of caspase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis
WX Huang et al.
MULTIPLE SCLEROSIS JOURNAL (2004)
α-synuclein locus triplication causes Parkinson's disease
AB Singleton et al.
SCIENCE (2003)
Nonsteroidal anti-inflammatory drugs and the risk of Parkinson disease
HL Chen et al.
ARCHIVES OF NEUROLOGY (2003)
Staging of brain pathology related to sporadic Parkinson's disease
H Braak et al.
NEUROBIOLOGY OF AGING (2003)
Interleukin 1 genotypes in multiple sclerosis and relationship to disease severity
CLA Mann et al.
JOURNAL OF NEUROIMMUNOLOGY (2002)
Production of IL-1β and IL-1Ra as risk factors for susceptibility and progression of relapse-onset multiple sclerosis
BA de Jong et al.
JOURNAL OF NEUROIMMUNOLOGY (2002)
Rapid secretion of interleukin-1β by microvesicle shedding
A MacKenzie et al.
IMMUNITY (2001)
Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
HM Hoffman et al.
NATURE GENETICS (2001)
Cytokines and acute neurodegeneration
SM Allan et al.
NATURE REVIEWS NEUROSCIENCE (2001)
Identification of a locus on chromosome 1q44 for familial cold urticaria
HM Hoffman et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2000)
Staging of multiple sclerosis (MS) lesions: pathology of the time frame of MS
P van der Valk et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2000)
Share Paper
