Journal
TRANSLATIONAL ONCOLOGY
Volume 21, Issue -, Pages -Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.tranon.2022.101434
Keywords
miRNAs; Argonaute protein; RBPs; mRNAs; miRISC; Cancer
Categories
Funding
- Memorial University of Newfoundland (MUN), St. John's, NL, Canada
Ask authors/readers for more resources
The interplay between miRNA-AGO and multiple RBPs determines the fate of target mRNA and plays a crucial role in cancer initiation and progression.
MicroRNAs (miRNAs) and RNA-binding proteins (RBPs) are important regulators of mRNA translation and stability in eukaryotes. While miRNAs can only bind their target mRNAs in association with Argonaute proteins (AGOs), RBPs directly bind their targets either as single entities or in complex with other RBPs to control mRNA metabolism. miRNA binding in 3' untranslated regions (3' UTRs) of mRNAs facilitates an intricate network of interactions between miRNA-AGO and RBPs, thus determining the fate of overlapping targets. Here, we review the current knowledge on the interplay between miRNA-AGO and multiple RBPs in different cellular contexts, the rules underlying their synergism and antagonism on target mRNAs, as well as highlight the implications of these regulatory modules in cancer initiation and progression.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
