Journal
TOXICOLOGY LETTERS
Volume 367, Issue -, Pages 40-47Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.toxlet.2022.07.007
Keywords
Silica nanoparticles; Corona; Erythrocytes; Eryptosis; Hemolysis
Categories
Funding
- National Natural Science Foundation of China [21976145, 22176206]
Ask authors/readers for more resources
Silica nanoparticles (SiO2 NPs) have potential hazards to human health, but their hemolytic properties vary under different coatings. The results emphasize the influence of surface modification on the toxicity of environmental nanoparticles.
Silica nanoparticles (SiO2 NPs) have been widely manufactured for various applications and unintentionally generated in various industrial processes. SiO2 NPs exposure is potentially hazardous to human health. Incremental evidence has indicated the presence of SiO2 NPs in systemic circulation, which warranted their interaction with blood components. Due to the obvious weakness of hemolysis in the risk assessment of environmental NPs, we for the first time use eryptosis as a sensitive indicator to assess the hematotoxicity of SiO2 NPs. In vitro results showed that the exposure of erythrocytes to pristine SiO2 NPs resulted in typical features of eryptosis, including oxidative stress, calcium influx, phosphatidylserine externalization and hemolysis. However, SiO2 NPs covered with mouse plasma (SiO2@MP) or grafted with polyvinylpyrrolidone (SiO2@PVP) did not stimulate eryptosis. Interestingly, neither bare nor macromolecule-decolorated SiO2 NPs caused eryptosis in our in vivo mouse model, highlighting the protective role of coronal proteins on the amelioration of SiO2 NPs-induced hematotoxicity. These results emphasized the influences of surface modification on the toxicity of environmental NPs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available