4.7 Article

Low-dose arsenic trioxide enhances membrane-GLUT1 expression and glucose uptake via AKT activation to support L-02 cell aberrant proliferation

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Summary: Arsenic is a recognized carcinogen for humans. Chronic exposure to low-doses of inorganic arsenic leads to malignant proliferation of human hepatocyte L-02 cells. Arsenic-transformed malignant cells show increased levels of ROS, Cyclin D1 expression, and aerobic glycolysis. Activation of Akt pathway is observed in L-02-As cells, resulting in upregulation of Cyclin D1 and HK2 expression. ROS mediates Akt activation in L-02-As cells, contributing to the malignant phenotype of arsenic-transformed human hepatocyte L-02-As.

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