A convenient synthesis of linezolid through Buchwald-Hartwig amination

A new method was developed for the synthesis of Linezolid from commercially available (R)-3-(4-bromo-3-fluorophenyl)-5-(hydroxymethyl)oxazolidin-2-one. Linezolid is an antibiotic belongs to the family of oxazolidinones, it is successfully synthesized through a new method which include Buchwald-Hartwig amination reaction and Gabriel amine synthesis as the key steps. The synthetic route is easy to perform and with high yield. This new method provides a huge possibility for the synthesis of new linezolid derivatives that may possibly tackle the problem of bacteria resistance to oxazolidinones.(c) 2022 Elsevier Ltd. All rights reserved.

Automated summary

A new method for synthesizing Linezolid, an antibiotic belonging to the family of oxazolidinones, was developed. The method involves Buchwald-Hartwig amination reaction and Gabriel amine synthesis as key steps and has shown high efficiency and easy operation. This new method opens up possibilities for synthesizing new Linezolid derivatives that may help address bacteria resistance to oxazolidinones.